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- Scopus: eid_2-s2.0-42149186503
- PMID: 18366005
- WOS: WOS:000254993700003
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Article: Expression of claudin-2 in the multistage process of gastric carcinogenesis.
Title | Expression of claudin-2 in the multistage process of gastric carcinogenesis. |
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Authors | |
Keywords | Claudin-2 Expression Gastric cancer Immunohistochemistry Tight junction |
Issue Date | 2008 |
Citation | Histology And Histopathology, 2008, v. 23 n. 6, p. 673-682 How to Cite? |
Abstract | OBJECTIVE: Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity. METHODS: This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy. To determine claudin-2 expression in gastric carcinogenesis by immunochemical ABC technique. RESULTS: Altogether, 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples were analyzed. Results indicated that the percentage of claudin-2-positive cases was 0% for chronic superficial gastritis (0/108), 0% for chronic atrophic gastritis (0/55), 0% for intestinal-type metaplasia (0/109), 35.87% for dysplasia (33/92), and 73.47% for gastric intestinal-type adenocarcinoma (36/49) respectively, primarily in the cell membrane, and gradually increased in the multistage process of gastric carcinogenesis (P<0.001). CONCLUSIONS: This suggests that claudin-2 protein overexpression may be closely correlated to gastric carcinogenesis. |
Persistent Identifier | http://hdl.handle.net/10722/163161 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.571 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, X | en_US |
dc.contributor.author | Li, X | en_US |
dc.contributor.author | Tang, Y | en_US |
dc.contributor.author | Chen, H | en_US |
dc.contributor.author | Wong, B | en_US |
dc.contributor.author | Wang, J | en_US |
dc.contributor.author | Chen, M | en_US |
dc.date.accessioned | 2012-09-05T05:28:20Z | - |
dc.date.available | 2012-09-05T05:28:20Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Histology And Histopathology, 2008, v. 23 n. 6, p. 673-682 | en_US |
dc.identifier.issn | 1699-5848 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163161 | - |
dc.description.abstract | OBJECTIVE: Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity. METHODS: This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy. To determine claudin-2 expression in gastric carcinogenesis by immunochemical ABC technique. RESULTS: Altogether, 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples were analyzed. Results indicated that the percentage of claudin-2-positive cases was 0% for chronic superficial gastritis (0/108), 0% for chronic atrophic gastritis (0/55), 0% for intestinal-type metaplasia (0/109), 35.87% for dysplasia (33/92), and 73.47% for gastric intestinal-type adenocarcinoma (36/49) respectively, primarily in the cell membrane, and gradually increased in the multistage process of gastric carcinogenesis (P<0.001). CONCLUSIONS: This suggests that claudin-2 protein overexpression may be closely correlated to gastric carcinogenesis. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Histology and histopathology | en_US |
dc.subject | Claudin-2 | - |
dc.subject | Expression | - |
dc.subject | Gastric cancer | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Tight junction | - |
dc.subject.mesh | Adenocarcinoma - Metabolism - Pathology | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 And Over | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fluorescent Antibody Technique, Indirect | en_US |
dc.subject.mesh | Gastric Mucosa - Metabolism - Pathology | en_US |
dc.subject.mesh | Gastritis, Atrophic - Metabolism - Pathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hyperplasia - Metabolism - Pathology | en_US |
dc.subject.mesh | Immunoenzyme Techniques | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Membrane Proteins - Metabolism | en_US |
dc.subject.mesh | Metaplasia - Metabolism - Pathology | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Precancerous Conditions - Metabolism - Pathology | en_US |
dc.subject.mesh | Stomach Neoplasms - Metabolism - Pathology | en_US |
dc.subject.mesh | Tumor Markers, Biological - Metabolism | en_US |
dc.title | Expression of claudin-2 in the multistage process of gastric carcinogenesis. | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wong, B:bcywong@hku.hk | en_US |
dc.identifier.authority | Wong, B=rp00429 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 18366005 | en_US |
dc.identifier.scopus | eid_2-s2.0-42149186503 | en_US |
dc.identifier.volume | 23 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 673 | en_US |
dc.identifier.epage | 682 | en_US |
dc.identifier.isi | WOS:000254993700003 | - |
dc.identifier.scopusauthorid | Song, X=13002663000 | en_US |
dc.identifier.scopusauthorid | Li, X=23469678400 | en_US |
dc.identifier.scopusauthorid | Tang, Y=35187706500 | en_US |
dc.identifier.scopusauthorid | Chen, H=8834467700 | en_US |
dc.identifier.scopusauthorid | Wong, B=7402023340 | en_US |
dc.identifier.scopusauthorid | Wang, J=34977817900 | en_US |
dc.identifier.scopusauthorid | Chen, M=8642044500 | en_US |
dc.identifier.issnl | 0213-3911 | - |