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Article: Two cases of therapy-related acute promyelocytic leukemia (t-APL) after mantle cell lymphoma and gestational trophoblastic disease

TitleTwo cases of therapy-related acute promyelocytic leukemia (t-APL) after mantle cell lymphoma and gestational trophoblastic disease
Authors
Au, WYMa, SKChung, LPChim, CSKwong, YL
KeywordsArsenic
Gestational trophoblastic disease
Mantle cell lymphoma
Secondary APL
Issue Date2002
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htm
Citation
Annals Of Hematology, 2002, v. 81 n. 11, p. 659-661 How to Cite?
DOI: http://dx.doi.org/10.1007/s00277-002-0552-6
AbstractWe report two cases of secondary acute promyelocytic leukemia (APL). One patient presented with concurrent APL and missed abortion 1 year after etoposide-based chemotherapy for gestational trophoblastic disease. A prolonged complete remission was achieved with standard chemotherapy. An elderly man developed APL 1 year after alkylator-based chemotherapy for mantle cell lymphoma (MCL). A complete clinical and molecular remission was obtained with chemotherapy and all-trans retinoic acid, followed by arsenic consolidation. Concomitant molecular relapse of APL and MCL clones was detected at 1 year, both of which responded to oral arsenic therapy. High-dose epipodophyllin is a dose risk for secondary APL, but alkylating agents may also be implicated. For patients with a history of active malignancy and heavy previous chemotherapy exposure, the use of nontoxic arsenic therapy appeared to be effective and prudent.
Persistent Identifierhttp://hdl.handle.net/10722/162647
ISSN
0939-5555
2021 Impact Factor: 4.030
2020 SCImago Journal Rankings: 1.079
ISI Accession Number ID
WOS:000179992200010
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorChung, LPen_HK
dc.contributor.authorChim, CSen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2012-09-05T05:22:02Z-
dc.date.available2012-09-05T05:22:02Z-
dc.date.issued2002en_HK
dc.identifier.citationAnnals Of Hematology, 2002, v. 81 n. 11, p. 659-661en_HK
dc.identifier.issn0939-5555en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162647-
dc.description.abstractWe report two cases of secondary acute promyelocytic leukemia (APL). One patient presented with concurrent APL and missed abortion 1 year after etoposide-based chemotherapy for gestational trophoblastic disease. A prolonged complete remission was achieved with standard chemotherapy. An elderly man developed APL 1 year after alkylator-based chemotherapy for mantle cell lymphoma (MCL). A complete clinical and molecular remission was obtained with chemotherapy and all-trans retinoic acid, followed by arsenic consolidation. Concomitant molecular relapse of APL and MCL clones was detected at 1 year, both of which responded to oral arsenic therapy. High-dose epipodophyllin is a dose risk for secondary APL, but alkylating agents may also be implicated. For patients with a history of active malignancy and heavy previous chemotherapy exposure, the use of nontoxic arsenic therapy appeared to be effective and prudent.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htmen_HK
dc.relation.ispartofAnnals of Hematologyen_HK
dc.subjectArsenicen_HK
dc.subjectGestational trophoblastic diseaseen_HK
dc.subjectMantle cell lymphomaen_HK
dc.subjectSecondary APLen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntineoplastic Agents, Alkylating - Adverse Effects - Therapeutic Useen_US
dc.subject.meshArsenicals - Therapeutic Useen_US
dc.subject.meshEtoposide - Adverse Effects - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshGestational Trophoblastic Disease - Drug Therapy - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Promyelocytic, Acute - Chemically Induced - Drug Therapy - Etiologyen_US
dc.subject.meshLymphoma, Mantle-Cell - Drug Therapy - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasms, Second Primary - Drug Therapy - Etiologyen_US
dc.subject.meshOxides - Therapeutic Useen_US
dc.subject.meshPregnancyen_US
dc.subject.meshTretinoin - Therapeutic Useen_US
dc.titleTwo cases of therapy-related acute promyelocytic leukemia (t-APL) after mantle cell lymphoma and gestational trophoblastic diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.emailKwong, YL: ylkwong@hku.hken_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00277-002-0552-6en_HK
dc.identifier.pmid12454706-
dc.identifier.scopuseid_2-s2.0-0036938435en_HK
dc.identifier.hkuros77876-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036938435&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume81en_HK
dc.identifier.issue11en_HK
dc.identifier.spage659en_HK
dc.identifier.epage661en_HK
dc.identifier.isiWOS:000179992200010-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridMa, SK=37020910400en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK
dc.identifier.scopusauthoridShim, CS=7103280886en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.issnl0939-5555-

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