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Article: Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer

TitleAssociation between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer
Authors
Leung, WKTo, KFNg, YPLee, TLLau, JYWChan, FKLNg, EKWChung, SCSSung, JJY
KeywordsCyclo-oxygenase-2
Gastric cancer
Mutation
p53 gene
Issue Date2001
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 2001, v. 84 n. 3, p. 335-339 How to Cite?
DOI: http://dx.doi.org/10.1054/bjoc.2000.1607
AbstractWild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer. © 2001 Cancer Research Campaign.
Persistent Identifierhttp://hdl.handle.net/10722/162506
ISSN
0007-0920
2021 Impact Factor: 9.075
2020 SCImago Journal Rankings: 2.833
ISI Accession Number ID
WOS:000166995400007
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLeung, WKen_US
dc.contributor.authorTo, KFen_US
dc.contributor.authorNg, YPen_US
dc.contributor.authorLee, TLen_US
dc.contributor.authorLau, JYWen_US
dc.contributor.authorChan, FKLen_US
dc.contributor.authorNg, EKWen_US
dc.contributor.authorChung, SCSen_US
dc.contributor.authorSung, JJYen_US
dc.date.accessioned2012-09-05T05:20:36Z-
dc.date.available2012-09-05T05:20:36Z-
dc.date.issued2001en_US
dc.identifier.citationBritish Journal Of Cancer, 2001, v. 84 n. 3, p. 335-339en_US
dc.identifier.issn0007-0920en_US
dc.identifier.urihttp://hdl.handle.net/10722/162506-
dc.description.abstractWild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer. © 2001 Cancer Research Campaign.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_US
dc.relation.ispartofBritish Journal of Canceren_US
dc.subjectCyclo-oxygenase-2-
dc.subjectGastric cancer-
dc.subjectMutation-
dc.subjectp53 gene-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCyclooxygenase 2en_US
dc.subject.meshDna - Chemistry - Geneticsen_US
dc.subject.meshDna Mutational Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIsoenzymes - Biosynthesisen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Proteinsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMutation, Missenseen_US
dc.subject.meshPolymorphism, Single-Stranded Conformationalen_US
dc.subject.meshProstaglandin-Endoperoxide Synthases - Biosynthesisen_US
dc.subject.meshStomach Neoplasms - Enzymology - Genetics - Pathologyen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshTumor Suppressor Protein P53 - Geneticsen_US
dc.titleAssociation between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric canceren_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1054/bjoc.2000.1607en_US
dc.identifier.pmid11161397-
dc.identifier.scopuseid_2-s2.0-0035125626en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035125626&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume84en_US
dc.identifier.issue3en_US
dc.identifier.spage335en_US
dc.identifier.epage339en_US
dc.identifier.isiWOS:000166995400007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridTo, KF=7101911940en_US
dc.identifier.scopusauthoridNg, YP=7202471018en_US
dc.identifier.scopusauthoridLee, TL=35292432600en_US
dc.identifier.scopusauthoridLau, JYW=13907867100en_US
dc.identifier.scopusauthoridChan, FKL=7202586434en_US
dc.identifier.scopusauthoridNg, EKW=7201647539en_US
dc.identifier.scopusauthoridChung, SCS=19642462800en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US
dc.identifier.issnl0007-0920-

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