File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1159/000125275
- Scopus: eid_2-s2.0-0024441608
- PMID: 2514393
- WOS: WOS:A1989AW32100007
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Pituitary vasoactive intestinal peptide regulates prolactin secretion in the hypothyroid rat
Title | Pituitary vasoactive intestinal peptide regulates prolactin secretion in the hypothyroid rat |
---|---|
Authors | |
Issue Date | 1989 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/NEN |
Citation | Neuroendocrinology, 1989, v. 50 n. 5, p. 524-528 How to Cite? |
Abstract | In this study, we demonstrated that the cell content and basal secretion of vasoactive intestinal peptide (VIP) in primary rat pituitary cell cultures were increased in hypothyroidism. VIP release from hypothyroid pituitary cells in vitro was stimulated by thyrotropin releasing hormone (TRH 10-8 to 10-6 M) and growth hormone (GH)-releasing hormone (GHRH 10-9 to 10-8 M) but not by corticotropin-releasing hormone or luteinizing hormone-releasing hormone in concentrations up to 10-6 M. In the presence of anti-VIP antisera, there was a significant decrease in basal prolactin secretion from cultured hypothyroid pituitary cells (p < 0.005) indicating that VIP exerts a tonic stimulatory effect on prolactin (PRL) secretion. The increment in PRL secretion following TRH was not affected by exposure to anti-VIP indicating that PRL release after TRH is not mediated by VIP at the pituitary level. In contrast to changes in PRL, exposure to anti-VIP had no effect on basal GH secretion, indicating that the PRL changes are hormone specific. Similarly, GHRH-induced GH release was unaffected by VIP immunoneutralization. |
Persistent Identifier | http://hdl.handle.net/10722/161788 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 1.009 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lam, KSL | en_US |
dc.contributor.author | Reichlin, S | en_US |
dc.date.accessioned | 2012-09-05T05:14:58Z | - |
dc.date.available | 2012-09-05T05:14:58Z | - |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Neuroendocrinology, 1989, v. 50 n. 5, p. 524-528 | en_US |
dc.identifier.issn | 0028-3835 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/161788 | - |
dc.description.abstract | In this study, we demonstrated that the cell content and basal secretion of vasoactive intestinal peptide (VIP) in primary rat pituitary cell cultures were increased in hypothyroidism. VIP release from hypothyroid pituitary cells in vitro was stimulated by thyrotropin releasing hormone (TRH 10-8 to 10-6 M) and growth hormone (GH)-releasing hormone (GHRH 10-9 to 10-8 M) but not by corticotropin-releasing hormone or luteinizing hormone-releasing hormone in concentrations up to 10-6 M. In the presence of anti-VIP antisera, there was a significant decrease in basal prolactin secretion from cultured hypothyroid pituitary cells (p < 0.005) indicating that VIP exerts a tonic stimulatory effect on prolactin (PRL) secretion. The increment in PRL secretion following TRH was not affected by exposure to anti-VIP indicating that PRL release after TRH is not mediated by VIP at the pituitary level. In contrast to changes in PRL, exposure to anti-VIP had no effect on basal GH secretion, indicating that the PRL changes are hormone specific. Similarly, GHRH-induced GH release was unaffected by VIP immunoneutralization. | en_US |
dc.language | eng | en_US |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/NEN | en_US |
dc.relation.ispartof | Neuroendocrinology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Growth Hormone - Secretion | en_US |
dc.subject.mesh | Growth Hormone-Releasing Hormone - Physiology | en_US |
dc.subject.mesh | Hypothyroidism - Physiopathology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pituitary Gland - Secretion | en_US |
dc.subject.mesh | Prolactin - Secretion | en_US |
dc.subject.mesh | Radioimmunoassay | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Thyrotropin - Physiology | en_US |
dc.subject.mesh | Thyrotropin-Releasing Hormone - Physiology | en_US |
dc.subject.mesh | Thyroxine - Physiology | en_US |
dc.subject.mesh | Vasoactive Intestinal Peptide - Physiology | en_US |
dc.title | Pituitary vasoactive intestinal peptide regulates prolactin secretion in the hypothyroid rat | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lam, KSL:ksllam@hku.hk | en_US |
dc.identifier.authority | Lam, KSL=rp00343 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1159/000125275 | - |
dc.identifier.pmid | 2514393 | - |
dc.identifier.scopus | eid_2-s2.0-0024441608 | en_US |
dc.identifier.volume | 50 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 524 | en_US |
dc.identifier.epage | 528 | en_US |
dc.identifier.isi | WOS:A1989AW32100007 | - |
dc.publisher.place | Switzerland | en_US |
dc.identifier.scopusauthorid | Lam, KSL=8082870600 | en_US |
dc.identifier.scopusauthorid | Reichlin, S=16186732300 | en_US |
dc.identifier.issnl | 0028-3835 | - |