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Article: Strong association between HLA DRw9 and Hashimoto's thyroiditis in Southern Chinese

TitleStrong association between HLA DRw9 and Hashimoto's thyroiditis in Southern Chinese
Authors
Hawkins, BRLam, KSLMa, JTC
Issue Date1987
Citation
Acta Endocrinologica, 1987, v. 114 n. 4, p. 543-546 How to Cite?
DOI: http://dx.doi.org/10.1530/acta.0.1140543
AbstractThe distribution of HLA-A, -B, and -DR antigens in 53 Southern Chinese patients with Hashimoto's thyroiditis including 33 with goitre and 20 without goitre was compared with the distribution in 100 Southern Chinese controls. There was a significantly increased prevalence of HLA Bw46 in the nongoiterous patients and of HLA DRw9 in both groups of patients, but only for HLA DRw9 in the goiterous group was the increase significant after adjustment for the number of antigens studied. Based on these findings and those in other autoimmune diseases it is considered that the haplotype Bw46, DRw9 in Chinese takes the place of B8, DR3 in Caucasians in carrying genes which predispose to the development of autoimmune disease.
Persistent Identifierhttp://hdl.handle.net/10722/161717
ISSN
0001-5598
2019 SCImago Journal Rankings: 0.125
ISI Accession Number ID
WOS:A1987G735800014

 

DC FieldValueLanguage
dc.contributor.authorHawkins, BRen_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorMa, JTCen_US
dc.date.accessioned2012-09-05T05:14:18Z-
dc.date.available2012-09-05T05:14:18Z-
dc.date.issued1987en_US
dc.identifier.citationActa Endocrinologica, 1987, v. 114 n. 4, p. 543-546en_US
dc.identifier.issn0001-5598en_US
dc.identifier.urihttp://hdl.handle.net/10722/161717-
dc.description.abstractThe distribution of HLA-A, -B, and -DR antigens in 53 Southern Chinese patients with Hashimoto's thyroiditis including 33 with goitre and 20 without goitre was compared with the distribution in 100 Southern Chinese controls. There was a significantly increased prevalence of HLA Bw46 in the nongoiterous patients and of HLA DRw9 in both groups of patients, but only for HLA DRw9 in the goiterous group was the increase significant after adjustment for the number of antigens studied. Based on these findings and those in other autoimmune diseases it is considered that the haplotype Bw46, DRw9 in Chinese takes the place of B8, DR3 in Caucasians in carrying genes which predispose to the development of autoimmune disease.en_US
dc.languageengen_US
dc.relation.ispartofActa Endocrinologicaen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGoiter - Ethnology - Immunologyen_US
dc.subject.meshHla Antigens - Geneticsen_US
dc.subject.meshHla-A Antigensen_US
dc.subject.meshHla-B Antigensen_US
dc.subject.meshHla-D Antigens - Geneticsen_US
dc.subject.meshHla-Dr Antigens - Geneticsen_US
dc.subject.meshHla-Dr Serological Subtypesen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshThyroiditis, Autoimmune - Ethnology - Immunologyen_US
dc.titleStrong association between HLA DRw9 and Hashimoto's thyroiditis in Southern Chineseen_US
dc.typeArticleen_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1530/acta.0.1140543-
dc.identifier.pmid3472422-
dc.identifier.scopuseid_2-s2.0-0023100257en_US
dc.identifier.volume114en_US
dc.identifier.issue4en_US
dc.identifier.spage543en_US
dc.identifier.epage546en_US
dc.identifier.isiWOS:A1987G735800014-
dc.identifier.scopusauthoridHawkins, BR=35944486200en_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US
dc.identifier.scopusauthoridMa, JTC=24491943700en_US
dc.identifier.issnl0001-5598-

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