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- Publisher Website: 10.1155/2011/180594
- Scopus: eid_2-s2.0-84855554053
- PMID: 22203782
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Article: Pathophysiology of the peritoneal membrane during peritoneal dialysis: the role of hyaluronan
Title | Pathophysiology of the peritoneal membrane during peritoneal dialysis: the role of hyaluronan |
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Authors | |
Issue Date | 2011 |
Publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html |
Citation | Journal of Biomedicine and Biotechnology, 2011, v. 2011, article no. 180594 How to Cite? |
Abstract | During peritoneal dialysis (PD), constant exposure of mesothelial cells to bioincompatible PD solutions results in the denudation of the mesothelial monolayer and impairment of mesothelial cell function. Hyaluronan, a major component of extracellular matrices, is synthesized by mesothelial cells and contributes to remesothelialization, maintenance of cell phenotype, and tissue remodeling and provides structural support to the peritoneal membrane. Chronic peritoneal inflammation is observed in long-term PD patients and is associated with increased hyaluronan synthesis. During inflammation, depolymerization of hyaluronan may occur with the generation of hyaluronan fragments. In contrast to native hyaluronan which offers a protective role to the peritoneum, hyaluronan fragments exacerbate inflammatory and fibrotic processes and therefore assist in the destruction of the tissue. This paper will discuss the contribution of mesothelial cells to peritoneal membrane alterations that are induced by PD and the putative role of hyaluronan in these processes. |
Persistent Identifier | http://hdl.handle.net/10722/159690 |
ISSN | 2014 Impact Factor: 3.169 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yung, S | en_US |
dc.contributor.author | Chan, TM | en_US |
dc.date.accessioned | 2012-08-16T05:54:04Z | - |
dc.date.available | 2012-08-16T05:54:04Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Journal of Biomedicine and Biotechnology, 2011, v. 2011, article no. 180594 | en_US |
dc.identifier.issn | 1110-7243 | - |
dc.identifier.uri | http://hdl.handle.net/10722/159690 | - |
dc.description.abstract | During peritoneal dialysis (PD), constant exposure of mesothelial cells to bioincompatible PD solutions results in the denudation of the mesothelial monolayer and impairment of mesothelial cell function. Hyaluronan, a major component of extracellular matrices, is synthesized by mesothelial cells and contributes to remesothelialization, maintenance of cell phenotype, and tissue remodeling and provides structural support to the peritoneal membrane. Chronic peritoneal inflammation is observed in long-term PD patients and is associated with increased hyaluronan synthesis. During inflammation, depolymerization of hyaluronan may occur with the generation of hyaluronan fragments. In contrast to native hyaluronan which offers a protective role to the peritoneum, hyaluronan fragments exacerbate inflammatory and fibrotic processes and therefore assist in the destruction of the tissue. This paper will discuss the contribution of mesothelial cells to peritoneal membrane alterations that are induced by PD and the putative role of hyaluronan in these processes. | - |
dc.language | eng | en_US |
dc.publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html | - |
dc.relation.ispartof | Journal of Biomedicine and Biotechnology | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject.mesh | Dialysis Solutions - adverse effects | - |
dc.subject.mesh | Epithelial Cells - metabolism - secretion | - |
dc.subject.mesh | Hyaluronic Acid - metabolism - secretion | - |
dc.subject.mesh | Peritoneal Dialysis - adverse effects | - |
dc.subject.mesh | Peritoneum - physiopathology | - |
dc.title | Pathophysiology of the peritoneal membrane during peritoneal dialysis: the role of hyaluronan | en_US |
dc.type | Article | en_US |
dc.identifier.email | Yung, S: ssyyung@hku.hk | en_US |
dc.identifier.email | Chan, TM: dtmchan@hku.hk | en_US |
dc.identifier.authority | Yung, SSY=rp00455 | en_US |
dc.identifier.authority | Chan, DTM=rp00394 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1155/2011/180594 | - |
dc.identifier.pmid | 22203782 | - |
dc.identifier.pmcid | PMC3238805 | - |
dc.identifier.scopus | eid_2-s2.0-84855554053 | - |
dc.identifier.hkuros | 204924 | en_US |
dc.identifier.volume | 2011, article no. 180594 | - |
dc.identifier.isi | WOS:000298679800001 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1110-7243 | - |