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Conference Paper: A modified Newton's method for inverse problem of Probabilistic Boolean Networks with gene perturbations

TitleA modified Newton's method for inverse problem of Probabilistic Boolean Networks with gene perturbations
Authors
Li, WChing, WKCui, LB
KeywordsGene Perturbation
Inversion Problem
Modify Newton's Method
Probabilistic Boolean Networks
Issue Date2011
Citation
2011 Ieee International Conference On Systems Biology, Isb 2011, 2011, p. 167-172 How to Cite?
DOI: http://dx.doi.org/10.1109/ISB.2011.6033150
AbstractModeling genetic regulatory networks is an important research issue in systems biology. Many mathematical models have been proposed, and among these models, Boolean Network (BN) and its extension Probabilistic Boolean Network (PBN) are popular. In this paper we consider the problem constructing PBNs with gene perturbations. We propose a modified Newton's method to get the gene perturbation probability of the captured problem. Numerical experiments are given to demonstrate both effectiveness and efficiency of our proposed method. © 2011 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/158880
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLi, Wen_US
dc.contributor.authorChing, WKen_US
dc.contributor.authorCui, LBen_US
dc.date.accessioned2012-08-08T09:04:04Z-
dc.date.available2012-08-08T09:04:04Z-
dc.date.issued2011en_US
dc.identifier.citation2011 Ieee International Conference On Systems Biology, Isb 2011, 2011, p. 167-172en_US
dc.identifier.urihttp://hdl.handle.net/10722/158880-
dc.description.abstractModeling genetic regulatory networks is an important research issue in systems biology. Many mathematical models have been proposed, and among these models, Boolean Network (BN) and its extension Probabilistic Boolean Network (PBN) are popular. In this paper we consider the problem constructing PBNs with gene perturbations. We propose a modified Newton's method to get the gene perturbation probability of the captured problem. Numerical experiments are given to demonstrate both effectiveness and efficiency of our proposed method. © 2011 IEEE.en_US
dc.languageengen_US
dc.relation.ispartof2011 IEEE International Conference on Systems Biology, ISB 2011en_US
dc.subjectGene Perturbationen_US
dc.subjectInversion Problemen_US
dc.subjectModify Newton's Methoden_US
dc.subjectProbabilistic Boolean Networksen_US
dc.titleA modified Newton's method for inverse problem of Probabilistic Boolean Networks with gene perturbationsen_US
dc.typeConference_Paperen_US
dc.identifier.emailChing, WK:wching@hku.hken_US
dc.identifier.authorityChing, WK=rp00679en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1109/ISB.2011.6033150en_US
dc.identifier.scopuseid_2-s2.0-80054865998en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80054865998&selection=ref&src=s&origin=recordpageen_US
dc.identifier.spage167en_US
dc.identifier.epage172en_US
dc.identifier.scopusauthoridLi, W=36068145000en_US
dc.identifier.scopusauthoridChing, WK=13310265500en_US
dc.identifier.scopusauthoridCui, LB=55042943500en_US

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