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Article: Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong
Title | Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong | ||||
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Authors | |||||
Keywords | Antimicrobial resistance Day care centers Molecular epidemiology MRSA Staphylococcus aureus | ||||
Issue Date | 2012 | ||||
Publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf | ||||
Citation | Journal of Infection, 2012, v. 64 n. 5, p. 500-506 How to Cite? | ||||
Abstract | OBJECTIVES: To investigate the prevalence and molecular epidemiology of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) nasal carriage in children. METHODS: We collected nasal and nasopharyngeal swabs from 2211 children aged 2-5 years attending 79 day care centers (DCCs) and 113 kindergartens (KGs) in all 18 geographical districts in Hong Kong. RESULTS: The overall carriage rates of S. aureus and MRSA were 27.6% (95% confidence interval [CI], 24.8-28.5%) and 1.3% (95% CI, 0.8-1.8%), respectively. Molecular typing (staphylococcal cassette chromosome mec [SCCmec], sequence type [ST], clonal cluster [CC]) showed that all the 28 MRSA isolates had SCCmec IV (n = 13) or V (n = 15) including 12 isolates with community-associated-MRSA genotypes (ST59-IV/V, ST30-IV and ST88-V), 10 isolates with healthcare-associated-MRSA genotypes (ST45-IV/V, CC5-IV and ST630-V) and six isolates with novel genotypes (ST10-V and CC1-IV). Spa typing indicated that there was some within and between DCCs/KGs transmission of certain MRSA and methicillin-sensitive S. aureus strains but this was not extensive. CONCLUSION: Our findings indicate the potential for DCCs to be a reservoir for emerging MRSA genotypes and highlight the need to enhance education and infection control measures to reduce their cross-transmission in this population. | ||||
Persistent Identifier | http://hdl.handle.net/10722/157689 | ||||
ISSN | 2023 Impact Factor: 14.3 2023 SCImago Journal Rankings: 2.669 | ||||
ISI Accession Number ID |
Funding Information: The work is supported by a research grant from the Research Fund for the Control of Infectious Diseases (RFCID) of the Health and Food Bureau of the Hong Kong SAR Government. | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ho, PL | en_HK |
dc.contributor.author | Chiu, SS | en_HK |
dc.contributor.author | Chan, MY | en_HK |
dc.contributor.author | Gan, Y | en_HK |
dc.contributor.author | Chow, KH | en_HK |
dc.contributor.author | Lai, EL | en_HK |
dc.contributor.author | Lau, YL | en_HK |
dc.date.accessioned | 2012-08-08T08:52:16Z | - |
dc.date.available | 2012-08-08T08:52:16Z | - |
dc.date.issued | 2012 | en_HK |
dc.identifier.citation | Journal of Infection, 2012, v. 64 n. 5, p. 500-506 | en_HK |
dc.identifier.issn | 0163-4453 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/157689 | - |
dc.description.abstract | OBJECTIVES: To investigate the prevalence and molecular epidemiology of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) nasal carriage in children. METHODS: We collected nasal and nasopharyngeal swabs from 2211 children aged 2-5 years attending 79 day care centers (DCCs) and 113 kindergartens (KGs) in all 18 geographical districts in Hong Kong. RESULTS: The overall carriage rates of S. aureus and MRSA were 27.6% (95% confidence interval [CI], 24.8-28.5%) and 1.3% (95% CI, 0.8-1.8%), respectively. Molecular typing (staphylococcal cassette chromosome mec [SCCmec], sequence type [ST], clonal cluster [CC]) showed that all the 28 MRSA isolates had SCCmec IV (n = 13) or V (n = 15) including 12 isolates with community-associated-MRSA genotypes (ST59-IV/V, ST30-IV and ST88-V), 10 isolates with healthcare-associated-MRSA genotypes (ST45-IV/V, CC5-IV and ST630-V) and six isolates with novel genotypes (ST10-V and CC1-IV). Spa typing indicated that there was some within and between DCCs/KGs transmission of certain MRSA and methicillin-sensitive S. aureus strains but this was not extensive. CONCLUSION: Our findings indicate the potential for DCCs to be a reservoir for emerging MRSA genotypes and highlight the need to enhance education and infection control measures to reduce their cross-transmission in this population. | en_HK |
dc.language | eng | en_US |
dc.publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf | en_HK |
dc.relation.ispartof | Journal of Infection | en_HK |
dc.rights | NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Infection, 2012, v. 64 n. 5, p. 500-506. DOI: 10.1016/j.jinf.2012.02.018 | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Antimicrobial resistance | - |
dc.subject | Day care centers | - |
dc.subject | Molecular epidemiology | - |
dc.subject | MRSA | - |
dc.subject | Staphylococcus aureus | - |
dc.subject.mesh | Carrier State - epidemiology - microbiology | - |
dc.subject.mesh | Child Day Care Centers | - |
dc.subject.mesh | Methicillin-Resistant Staphylococcus aureus - classification - drug effects - genetics - isolation and purification | - |
dc.subject.mesh | Nose - microbiology | - |
dc.subject.mesh | Staphylococcal Infections - epidemiology - microbiology | - |
dc.title | Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Ho, PL: plho@hkucc.hku.hk | en_HK |
dc.identifier.email | Chiu, SS: ssschiu@hku.hk | en_HK |
dc.identifier.email | Chow, KH: khchowb@hku.hk | en_HK |
dc.identifier.email | Lau, YL: lauylung@hku.hk | en_HK |
dc.identifier.authority | Ho, PL=rp00406 | en_HK |
dc.identifier.authority | Chiu, SS=rp00421 | en_HK |
dc.identifier.authority | Chow, KH=rp00370 | en_HK |
dc.identifier.authority | Lau, YL=rp00361 | en_HK |
dc.description.nature | postprint | en_US |
dc.identifier.doi | 10.1016/j.jinf.2012.02.018 | en_HK |
dc.identifier.pmid | 22406412 | - |
dc.identifier.scopus | eid_2-s2.0-84859838790 | en_HK |
dc.identifier.hkuros | 200716 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84859838790&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 64 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 500 | en_HK |
dc.identifier.epage | 506 | en_HK |
dc.identifier.isi | WOS:000303000400005 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Lau, YL=7201403380 | en_HK |
dc.identifier.scopusauthorid | Lai, EL=55081620700 | en_HK |
dc.identifier.scopusauthorid | Chow, KH=7202180736 | en_HK |
dc.identifier.scopusauthorid | Gan, Y=55082076700 | en_HK |
dc.identifier.scopusauthorid | Chan, MY=37109508300 | en_HK |
dc.identifier.scopusauthorid | Chiu, SS=7202291500 | en_HK |
dc.identifier.scopusauthorid | Ho, PL=7402211363 | en_HK |
dc.identifier.issnl | 0163-4453 | - |