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Article: Emergence of enterovirus 71 "double-recombinant" strains belonging to a novel genotype D originating from southern China: First evidence for combination of intratypic and intertypic recombination events in EV71

TitleEmergence of enterovirus 71 "double-recombinant" strains belonging to a novel genotype D originating from southern China: First evidence for combination of intratypic and intertypic recombination events in EV71
Authors
Yip, CCYLau, SKPZhou, BZhang, MXTsoi, HWChan, KHChen, XCWoo, PCYYuen, KY
Issue Date2010
PublisherSpringer Wien. The Journal's web site is located at http://www.springer.com/springerwiennewyork/medicine/journal/705
Citation
Archives Of Virology, 2010, v. 155 n. 9, p. 1413-1424 How to Cite?
DOI: http://dx.doi.org/10.1007/s00705-010-0722-0
AbstractHand-foot-mouth disease due to enterovirus 71 (EV71) and coxsackievirus A16 (CA16) has recently caused large outbreaks in mainland China in 2008. We performed complete genome sequencing on two EV71 (SZ/HK08-5 and SZ/HK08-6) and two CA16 (SZ/HK08-3 and SZ/HK08-7) strains from patients in Shenzhen, China. Phylogenetic, similarity plot and bootscan analyses revealed recombination between EV71 genotypes B and C at the 2A-2B junction, and between EV71 genotype B and CA16 strain G-10 in the 3C region for EV71 strains. A similar phenomenon was also found upon further gene sequencing with other EV71 strains. Recombination between CA16 strain G-10 and EV71 genotype A at the 2A-2B junction was also observed for CA16 strains. The present "double-recombinant" EV71 strains circulating in China and other EV71 subgenotype "C4" strains represent an additional genotype, D. CA16 strains should also be classified into two genotypes. This represents the first evidence for a combination of intratypic and intertypic recombination in EV71 strains. © 2010 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/157604
ISSN
0304-8608
2021 Impact Factor: 2.685
2020 SCImago Journal Rankings: 0.943
ISI Accession Number ID
WOS:000282090900005
Funding AgencyGrant Number
University of Hong Kong
Research Grant Council Grant
Croucher Senior Medical Research Fellowship
Funding Information:

We are grateful for the generous support of Mr. Hui Hoy and Mr. Hui Ming in the genomic sequencing platform, and the support of Professor York Chow. This work is partly supported by the Committee on Research and Conference Grants, University Development Fund, HKU Special Research Achievement Award and Outstanding Young Researcher Award, The University of Hong Kong; Research Grant Council Grant; the Croucher Senior Medical Research Fellowship 2006-2007; the HKSAR Research Fund for the Control of Infectious Diseases of the Health, Welfare and Food Bureau, and Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for Department of Health, the Government of Hong Kong Special Administrative Region of China.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorYip, CCYen_HK
dc.contributor.authorLau, SKPen_HK
dc.contributor.authorZhou, Ben_HK
dc.contributor.authorZhang, MXen_HK
dc.contributor.authorTsoi, HWen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorChen, XCen_HK
dc.contributor.authorWoo, PCYen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2012-08-08T08:51:37Z-
dc.date.available2012-08-08T08:51:37Z-
dc.date.issued2010en_HK
dc.identifier.citationArchives Of Virology, 2010, v. 155 n. 9, p. 1413-1424en_HK
dc.identifier.issn0304-8608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/157604-
dc.description.abstractHand-foot-mouth disease due to enterovirus 71 (EV71) and coxsackievirus A16 (CA16) has recently caused large outbreaks in mainland China in 2008. We performed complete genome sequencing on two EV71 (SZ/HK08-5 and SZ/HK08-6) and two CA16 (SZ/HK08-3 and SZ/HK08-7) strains from patients in Shenzhen, China. Phylogenetic, similarity plot and bootscan analyses revealed recombination between EV71 genotypes B and C at the 2A-2B junction, and between EV71 genotype B and CA16 strain G-10 in the 3C region for EV71 strains. A similar phenomenon was also found upon further gene sequencing with other EV71 strains. Recombination between CA16 strain G-10 and EV71 genotype A at the 2A-2B junction was also observed for CA16 strains. The present "double-recombinant" EV71 strains circulating in China and other EV71 subgenotype "C4" strains represent an additional genotype, D. CA16 strains should also be classified into two genotypes. This represents the first evidence for a combination of intratypic and intertypic recombination in EV71 strains. © 2010 Springer-Verlag.en_HK
dc.languageengen_US
dc.publisherSpringer Wien. The Journal's web site is located at http://www.springer.com/springerwiennewyork/medicine/journal/705en_HK
dc.relation.ispartofArchives of Virologyen_HK
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshEnterovirus A, Human - Classification - Genetics - Isolation & Purificationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHand, Foot And Mouth Disease - Epidemiology - Virologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshRecombination, Geneticen_US
dc.titleEmergence of enterovirus 71 "double-recombinant" strains belonging to a novel genotype D originating from southern China: First evidence for combination of intratypic and intertypic recombination events in EV71en_HK
dc.typeArticleen_HK
dc.identifier.emailYip, CCY: yipcyril@hku.hken_HK
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hken_HK
dc.identifier.emailTsoi, HW: hwtsoi@hkucc.hku.hken_HK
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityYip, CCY=rp01721en_HK
dc.identifier.authorityLau, SKP=rp00486en_HK
dc.identifier.authorityTsoi, HW=rp00439en_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00705-010-0722-0en_HK
dc.identifier.pmid20549263-
dc.identifier.scopuseid_2-s2.0-77957017113en_HK
dc.identifier.hkuros178243-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957017113&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume155en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1413en_HK
dc.identifier.epage1424en_HK
dc.identifier.isiWOS:000282090900005-
dc.publisher.placeAustriaen_HK
dc.identifier.scopusauthoridYip, CCY=14016999800en_HK
dc.identifier.scopusauthoridLau, SKP=7401596211en_HK
dc.identifier.scopusauthoridZhou, B=7401906727en_HK
dc.identifier.scopusauthoridZhang, MX=7601556521en_HK
dc.identifier.scopusauthoridTsoi, HW=6603822102en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridChen, XC=8710357400en_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.citeulike7385119-
dc.identifier.issnl0304-8608-

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