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- Publisher Website: 10.1038/sj.cr.7290371
- Scopus: eid_2-s2.0-29244448022
- PMID: 16354572
- WOS: WOS:000234281600021
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Article: siRNA, miRNA and HIV: Promises and challenges
Title | siRNA, miRNA and HIV: Promises and challenges |
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Authors | |
Keywords | Human immunodeficiency virus type-1 MicroRNA RNA interference RNA-induced silencing complex Small interfering RNA Suppressor of siRNA Viral miRNA |
Issue Date | 2005 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/cr/marketing/index.html |
Citation | Cell Research, 2005, v. 15 n. 11-12, p. 935-946 How to Cite? |
Abstract | Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in length that play important roles in regulating gene expression. They are incorporated into an RNA-induced silencing complex (RISC) and serve as guides for silencing their corresponding target mRNAs based on complementary base-pairing. The promise of gene silencing has led many researchers to consider siRNA as an anti-viral tool. However, in long-term settings, many viruses appear to escape from this therapeutical strategy. An example of this may be seen in the case of human immunodeficiency virus type-1 (HIV-1) which is able to evade RNA silencing by either mutating the siRNA-targeted sequence or by encoding for a partial suppressor of RNAi (RNA interference). On the other hand, because miRNA targeting does not require absolute complementarity of base-pairing, mutational escape by viruses from miRNA-specified silencing may be more difficult to achieve. In this review, we discuss stratagems used by various viruses to avoid the cells' antiviral si/mi-RNA defenses and notions of how viruses might control and regulate host cell genes by encoding viral miRNAs (vmiRNAs). |
Persistent Identifier | http://hdl.handle.net/10722/157429 |
ISSN | 2021 Impact Factor: 46.297 2020 SCImago Journal Rankings: 7.395 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeung, ML | en_US |
dc.contributor.author | Bennasser, Y | en_US |
dc.contributor.author | Le, SY | en_US |
dc.contributor.author | Jeang, KT | en_US |
dc.date.accessioned | 2012-08-08T08:49:53Z | - |
dc.date.available | 2012-08-08T08:49:53Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Cell Research, 2005, v. 15 n. 11-12, p. 935-946 | en_US |
dc.identifier.issn | 1001-0602 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/157429 | - |
dc.description.abstract | Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in length that play important roles in regulating gene expression. They are incorporated into an RNA-induced silencing complex (RISC) and serve as guides for silencing their corresponding target mRNAs based on complementary base-pairing. The promise of gene silencing has led many researchers to consider siRNA as an anti-viral tool. However, in long-term settings, many viruses appear to escape from this therapeutical strategy. An example of this may be seen in the case of human immunodeficiency virus type-1 (HIV-1) which is able to evade RNA silencing by either mutating the siRNA-targeted sequence or by encoding for a partial suppressor of RNAi (RNA interference). On the other hand, because miRNA targeting does not require absolute complementarity of base-pairing, mutational escape by viruses from miRNA-specified silencing may be more difficult to achieve. In this review, we discuss stratagems used by various viruses to avoid the cells' antiviral si/mi-RNA defenses and notions of how viruses might control and regulate host cell genes by encoding viral miRNAs (vmiRNAs). | en_US |
dc.language | eng | en_US |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/cr/marketing/index.html | en_US |
dc.relation.ispartof | Cell Research | en_US |
dc.subject | Human immunodeficiency virus type-1 | - |
dc.subject | MicroRNA | - |
dc.subject | RNA interference | - |
dc.subject | RNA-induced silencing complex | - |
dc.subject | Small interfering RNA | - |
dc.subject | Suppressor of siRNA | - |
dc.subject | Viral miRNA | - |
dc.subject.mesh | Hiv - Genetics - Physiology | en_US |
dc.subject.mesh | Hiv Infections - Genetics - Metabolism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Micrornas - Isolation & Purification - Physiology | en_US |
dc.subject.mesh | Rna, Small Interfering - Isolation & Purification - Physiology | en_US |
dc.subject.mesh | Rna, Viral - Isolation & Purification - Physiology | en_US |
dc.title | siRNA, miRNA and HIV: Promises and challenges | en_US |
dc.type | Article | en_US |
dc.identifier.email | Yeung, ML:pmlyeung@hku.hk | en_US |
dc.identifier.authority | Yeung, ML=rp01402 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1038/sj.cr.7290371 | en_US |
dc.identifier.pmid | 16354572 | - |
dc.identifier.scopus | eid_2-s2.0-29244448022 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-29244448022&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 11-12 | en_US |
dc.identifier.spage | 935 | en_US |
dc.identifier.epage | 946 | en_US |
dc.identifier.isi | WOS:000234281600021 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Yeung, ML=8350940900 | en_US |
dc.identifier.scopusauthorid | Bennasser, Y=8335747500 | en_US |
dc.identifier.scopusauthorid | Le, SY=7006184376 | en_US |
dc.identifier.scopusauthorid | Jeang, KT=7004824803 | en_US |
dc.identifier.citeulike | 588376 | - |
dc.identifier.issnl | 1001-0602 | - |