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Article: Structural biology: Structure of a V3-containing HIV-1 gp120 core

TitleStructural biology: Structure of a V3-containing HIV-1 gp120 core
Authors
Huang, CCTang, MZhang, MYMajeed, SMontabana, EStanfield, RLDimitrov, DSKorber, BSodroski, JWilson, IAWyatt, RKwong, PD
Issue Date2005
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 2005, v. 310 n. 5750, p. 1025-1028 How to Cite?
DOI: http://dx.doi.org/10.1126/science.1118398
AbstractThe third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.
Persistent Identifierhttp://hdl.handle.net/10722/157424
ISSN
0036-8075
2021 Impact Factor: 63.714
2020 SCImago Journal Rankings: 12.556
ISI Accession Number ID
WOS:000233343400046
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorHuang, CCen_US
dc.contributor.authorTang, Men_US
dc.contributor.authorZhang, MYen_US
dc.contributor.authorMajeed, Sen_US
dc.contributor.authorMontabana, Een_US
dc.contributor.authorStanfield, RLen_US
dc.contributor.authorDimitrov, DSen_US
dc.contributor.authorKorber, Ben_US
dc.contributor.authorSodroski, Jen_US
dc.contributor.authorWilson, IAen_US
dc.contributor.authorWyatt, Ren_US
dc.contributor.authorKwong, PDen_US
dc.date.accessioned2012-08-08T08:49:51Z-
dc.date.available2012-08-08T08:49:51Z-
dc.date.issued2005en_US
dc.identifier.citationScience, 2005, v. 310 n. 5750, p. 1025-1028en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10722/157424-
dc.description.abstractThe third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_US
dc.relation.ispartofScienceen_US
dc.titleStructural biology: Structure of a V3-containing HIV-1 gp120 coreen_US
dc.typeArticleen_US
dc.identifier.emailZhang, MY:zhangmy@hku.hken_US
dc.identifier.authorityZhang, MY=rp01409en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1126/science.1118398en_US
dc.identifier.pmid16284180-
dc.identifier.scopuseid_2-s2.0-27744597054en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27744597054&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume310en_US
dc.identifier.issue5750en_US
dc.identifier.spage1025en_US
dc.identifier.epage1028en_US
dc.identifier.isiWOS:000233343400046-
dc.publisher.placeUnited Statesen_US
dc.identifier.f10001029423-
dc.identifier.scopusauthoridHuang, CC=7406888371en_US
dc.identifier.scopusauthoridTang, M=55205546900en_US
dc.identifier.scopusauthoridZhang, MY=35316639300en_US
dc.identifier.scopusauthoridMajeed, S=7006490845en_US
dc.identifier.scopusauthoridMontabana, E=9237658800en_US
dc.identifier.scopusauthoridStanfield, RL=35513093100en_US
dc.identifier.scopusauthoridDimitrov, DS=7202564539en_US
dc.identifier.scopusauthoridKorber, B=19335057200en_US
dc.identifier.scopusauthoridSodroski, J=7102286559en_US
dc.identifier.scopusauthoridWilson, IA=7401743864en_US
dc.identifier.scopusauthoridWyatt, R=7402848241en_US
dc.identifier.scopusauthoridKwong, PD=7006992407en_US
dc.identifier.citeulike436475-
dc.identifier.issnl0036-8075-

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