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- Publisher Website: 10.1016/S0140-6736(03)14901-X
- Scopus: eid_2-s2.0-10744223100
- PMID: 14654320
- WOS: WOS:000186872900013
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Article: Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong
Title | Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong |
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Authors | |
Issue Date | 2003 |
Publisher | The Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet |
Citation | Lancet, 2003, v. 362 n. 9398, p. 1807-1808 How to Cite? |
Abstract | Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak. |
Persistent Identifier | http://hdl.handle.net/10722/157383 |
ISSN | 2023 Impact Factor: 98.4 2023 SCImago Journal Rankings: 12.113 |
PubMed Central ID | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Chim, SSC | en_HK |
dc.contributor.author | Tsui, SKW | en_HK |
dc.contributor.author | Chan, KCA | en_HK |
dc.contributor.author | Au, TCC | en_HK |
dc.contributor.author | Hung, ECW | en_HK |
dc.contributor.author | Tong, YK | en_HK |
dc.contributor.author | Chiu, RWK | en_HK |
dc.contributor.author | Ng, EKO | en_HK |
dc.contributor.author | Chan, PKS | en_HK |
dc.contributor.author | Chu, CM | en_HK |
dc.contributor.author | Sung, JJY | en_HK |
dc.contributor.author | Tam, JS | en_HK |
dc.contributor.author | Fung, KP | en_HK |
dc.contributor.author | Waye, MMY | en_HK |
dc.contributor.author | Lee, CY | en_HK |
dc.contributor.author | Yuen, KY | en_HK |
dc.contributor.author | Lo, YMD | en_HK |
dc.date.accessioned | 2012-08-08T08:49:30Z | - |
dc.date.available | 2012-08-08T08:49:30Z | - |
dc.date.issued | 2003 | en_HK |
dc.identifier.citation | Lancet, 2003, v. 362 n. 9398, p. 1807-1808 | en_HK |
dc.identifier.issn | 0140-6736 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/157383 | - |
dc.description.abstract | Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak. | en_HK |
dc.language | eng | en_US |
dc.publisher | The Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet | en_HK |
dc.relation.ispartof | Lancet | en_HK |
dc.subject.mesh | Base Sequence - Genetics | en_US |
dc.subject.mesh | Cross Infection - Virology | en_US |
dc.subject.mesh | Disease Outbreaks - Statistics & Numerical Data | en_US |
dc.subject.mesh | Genome, Viral | en_US |
dc.subject.mesh | Hong Kong - Epidemiology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Sars Virus - Genetics | en_US |
dc.subject.mesh | Severe Acute Respiratory Syndrome - Diagnosis - Epidemiology - Virology | en_US |
dc.title | Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Ng, EKO: ngko@hku.hk | en_HK |
dc.identifier.email | Yuen, KY: kyyuen@hkucc.hku.hk | en_HK |
dc.identifier.authority | Ng, EKO=rp01364 | en_HK |
dc.identifier.authority | Yuen, KY=rp00366 | en_HK |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1016/S0140-6736(03)14901-X | en_HK |
dc.identifier.pmid | 14654320 | - |
dc.identifier.pmcid | PMC7119348 | - |
dc.identifier.scopus | eid_2-s2.0-10744223100 | en_HK |
dc.identifier.hkuros | 87969 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-10744223100&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 362 | en_HK |
dc.identifier.issue | 9398 | en_HK |
dc.identifier.spage | 1807 | en_HK |
dc.identifier.epage | 1808 | en_HK |
dc.identifier.isi | WOS:000186872900013 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Chim, SSC=6701728226 | en_HK |
dc.identifier.scopusauthorid | Tsui, SKW=7004961364 | en_HK |
dc.identifier.scopusauthorid | Chan, KCA=13403797200 | en_HK |
dc.identifier.scopusauthorid | Au, TCC=55225059600 | en_HK |
dc.identifier.scopusauthorid | Hung, ECW=7004256338 | en_HK |
dc.identifier.scopusauthorid | Tong, YK=7202614141 | en_HK |
dc.identifier.scopusauthorid | Chiu, RWK=7103038413 | en_HK |
dc.identifier.scopusauthorid | Ng, EKO=21135553700 | en_HK |
dc.identifier.scopusauthorid | Chan, PKS=7403497792 | en_HK |
dc.identifier.scopusauthorid | Chu, CM=7404345558 | en_HK |
dc.identifier.scopusauthorid | Sung, JJY=24473715000 | en_HK |
dc.identifier.scopusauthorid | Tam, JS=24788939600 | en_HK |
dc.identifier.scopusauthorid | Fung, KP=7202934739 | en_HK |
dc.identifier.scopusauthorid | Waye, MMY=7006687733 | en_HK |
dc.identifier.scopusauthorid | Lee, CY=7410142857 | en_HK |
dc.identifier.scopusauthorid | Yuen, KY=36078079100 | en_HK |
dc.identifier.scopusauthorid | Lo, YMD=7401935391 | en_HK |
dc.identifier.issnl | 0140-6736 | - |