File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Comparative study of retinal nerve fiber layer measurement by StratusOCT and GDx VCC, II: Structure/function regression analysis in glaucoma

TitleComparative study of retinal nerve fiber layer measurement by StratusOCT and GDx VCC, II: Structure/function regression analysis in glaucoma
Authors
Issue Date2005
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology and Visual Science, 2005, v. 46 n. 10, p. 3702-3711 How to Cite?
AbstractPURPOSE. To evaluate the structure/function relationship between visual field sensitivity and retinal nerve fiber layer (RNFL) thickness measured by StratusOCT (Carl Zeiss Meditec, Inc., Dublin, CA) and GDx VCC (Laser Diagnostic Technologies, Inc., San Diego, CA). METHODS. Eighty-nine subjects (27 who had healthy eyes, 21 who were glaucoma suspect, 41 who had glaucoma) were enrolled in this cross-sectional study. RNFL thickness was measured using the StratusOCT and the GDx VCC, and visual field (VF) was examined using the Humphrey VF analyzer. The relationship between RNFL thickness and VF sensitivity-expressed in terms of mean deviation (MD) in decibel (dB) scale, unlogged 1/lambert (L), and Advanced Glaucoma Intervention Study (AGIS) and Collaborative Initial Glaucoma Treatment Study (CIGTS) VF scores-were evaluated with linear and non-linear regression models. Coefficient of determination (R 2) was calculated, and regression models were compared using the Akaike information criterion and the F test. RESULTS. In plotting MD against RNFL thickness, curvilinear regression models demonstrated the best fit, whereas linear regression attained the best associations when VF sensitivity was xpressed in 1/L. However, when healthy subjects were excluded from the analyses, the second-order polynomial was better than linear regression in describing the relation between 1/L and GDx VCC-measured RNFL thickness. Regression profiles between AGIS/CIGTS VF scores and RNFL thickness were best described in the linear and the first-order inverse models for GDx VCC and StratusOCT RNFL measurements, respectively. In general, StratusOCT RNFL measurements achieved higher associations with visual function in all the respective regression analyses than did GDx VCC. CONCLUSIONS. Description of structure/function relationships in glaucoma depends on the choice of perimetry scale, the type of RNFL measuring device, and the characteristics of the studied groups. The higher association with visual function in StratusOCT RNFL measurements compared with that in GDx VCC suggested optical coherence tomography might be a better approach for evaluating structure/function relationships. Curvilinear regression profiles found between StratusOCT RNFL thickness and MD/VF scores provide an explanation for those longitudinal observations, showing that VFs with higher AGIS/CIGTS VF scores or worse MD at baseline are at higher risk for deterioration. Regression analysis of the structure/function profile could provide important information in the assessment of the trend and pattern of glaucoma progression. Copyright © Association for Research in Vision and Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/155885
ISSN
2023 Impact Factor: 5.0
2023 SCImago Journal Rankings: 1.422
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, CKSen_US
dc.contributor.authorChong, KKLen_US
dc.contributor.authorChan, WMen_US
dc.contributor.authorYiu, CKFen_US
dc.contributor.authorTso, MYen_US
dc.contributor.authorWoo, Jen_US
dc.contributor.authorTsang, MKen_US
dc.contributor.authorTse, KKen_US
dc.contributor.authorYung, WHen_US
dc.date.accessioned2012-08-08T08:38:12Z-
dc.date.available2012-08-08T08:38:12Z-
dc.date.issued2005en_US
dc.identifier.citationInvestigative Ophthalmology and Visual Science, 2005, v. 46 n. 10, p. 3702-3711en_US
dc.identifier.issn0146-0404en_US
dc.identifier.urihttp://hdl.handle.net/10722/155885-
dc.description.abstractPURPOSE. To evaluate the structure/function relationship between visual field sensitivity and retinal nerve fiber layer (RNFL) thickness measured by StratusOCT (Carl Zeiss Meditec, Inc., Dublin, CA) and GDx VCC (Laser Diagnostic Technologies, Inc., San Diego, CA). METHODS. Eighty-nine subjects (27 who had healthy eyes, 21 who were glaucoma suspect, 41 who had glaucoma) were enrolled in this cross-sectional study. RNFL thickness was measured using the StratusOCT and the GDx VCC, and visual field (VF) was examined using the Humphrey VF analyzer. The relationship between RNFL thickness and VF sensitivity-expressed in terms of mean deviation (MD) in decibel (dB) scale, unlogged 1/lambert (L), and Advanced Glaucoma Intervention Study (AGIS) and Collaborative Initial Glaucoma Treatment Study (CIGTS) VF scores-were evaluated with linear and non-linear regression models. Coefficient of determination (R 2) was calculated, and regression models were compared using the Akaike information criterion and the F test. RESULTS. In plotting MD against RNFL thickness, curvilinear regression models demonstrated the best fit, whereas linear regression attained the best associations when VF sensitivity was xpressed in 1/L. However, when healthy subjects were excluded from the analyses, the second-order polynomial was better than linear regression in describing the relation between 1/L and GDx VCC-measured RNFL thickness. Regression profiles between AGIS/CIGTS VF scores and RNFL thickness were best described in the linear and the first-order inverse models for GDx VCC and StratusOCT RNFL measurements, respectively. In general, StratusOCT RNFL measurements achieved higher associations with visual function in all the respective regression analyses than did GDx VCC. CONCLUSIONS. Description of structure/function relationships in glaucoma depends on the choice of perimetry scale, the type of RNFL measuring device, and the characteristics of the studied groups. The higher association with visual function in StratusOCT RNFL measurements compared with that in GDx VCC suggested optical coherence tomography might be a better approach for evaluating structure/function relationships. Curvilinear regression profiles found between StratusOCT RNFL thickness and MD/VF scores provide an explanation for those longitudinal observations, showing that VFs with higher AGIS/CIGTS VF scores or worse MD at baseline are at higher risk for deterioration. Regression analysis of the structure/function profile could provide important information in the assessment of the trend and pattern of glaucoma progression. Copyright © Association for Research in Vision and Ophthalmology.en_US
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_US
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_US
dc.titleComparative study of retinal nerve fiber layer measurement by StratusOCT and GDx VCC, II: Structure/function regression analysis in glaucomaen_US
dc.typeArticleen_US
dc.identifier.emailYiu, CKF:cedric@hkucc.hku.hken_US
dc.identifier.authorityYiu, CKF=rp00206en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1167/iovs.05-0490en_US
dc.identifier.pmid16186352-
dc.identifier.scopuseid_2-s2.0-32944464155en_US
dc.identifier.hkuros119300-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-32944464155&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume46en_US
dc.identifier.issue10en_US
dc.identifier.spage3702en_US
dc.identifier.epage3711en_US
dc.identifier.isiWOS:000232112900033-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, CKS=8834590400en_US
dc.identifier.scopusauthoridChong, KKL=36780032600en_US
dc.identifier.scopusauthoridChan, WM=7403914485en_US
dc.identifier.scopusauthoridYiu, CKF=24802813000en_US
dc.identifier.scopusauthoridTso, MY=12446729400en_US
dc.identifier.scopusauthoridWoo, J=8235327300en_US
dc.identifier.scopusauthoridTsang, MK=8963309600en_US
dc.identifier.scopusauthoridTse, KK=8834590300en_US
dc.identifier.scopusauthoridYung, WH=7103137893en_US
dc.identifier.issnl0146-0404-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats