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Article: Regional cerebral blood volume reduction in transgenic mutant APP (V717F, K670N/M671L) mice

TitleRegional cerebral blood volume reduction in transgenic mutant APP (V717F, K670N/M671L) mice
Authors
Wu, EXTang, HAsai, TYan, SD
KeywordsAD
Alzheimer's disease
Beta-amyloid
CBV
Cerebral blood volume
Vascular
Issue Date2004
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2004, v. 365 n. 3, p. 223-227 How to Cite?
DOI: http://dx.doi.org/10.1016/j.neulet.2004.05.004
AbstractRecent advance in nuclear magnetic resonance (NMR) microimaging has enabled in vivo cerebral blood volume (CBV) mapping with high spatial resolution. Using an intravascular susceptibility contrast agent and T 2-weighted magnetic resonance imaging (MRI) on a 9.4 T NMR microimager, the regional CBV was measured in mice as the transverse relaxation increase induced by the contrast agent. CBV maps in an Alzheimer's disease mouse model at resting state were obtained and examined. Four-month-old male transgenic mutant APP (V717F, K670N/M671L) mice (N = 10) and littermate wild-type controls (N = 12) were used. Regional analysis of the multi-slice CBV maps revealed statistically significant CBV reductions among the APP mice in cerebral cortex (-9.29%, P = 0.0002), hippocampus (-4.22%, P = 0.02), and thalamus (-5.21%, P = 0.03), indicating an early change of microvasculature in these selected regions. No significant difference was found in olfactory bulb, pons, midbrain, superior colliculus, medulla, and cerebellum. © 2004 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/155309
ISSN
0304-3940
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.745
ISI Accession Number ID
WOS:000222869500015
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorWu, EXen_US
dc.contributor.authorTang, Hen_US
dc.contributor.authorAsai, Ten_US
dc.contributor.authorYan, SDen_US
dc.date.accessioned2012-08-08T08:32:49Z-
dc.date.available2012-08-08T08:32:49Z-
dc.date.issued2004en_US
dc.identifier.citationNeuroscience Letters, 2004, v. 365 n. 3, p. 223-227en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/155309-
dc.description.abstractRecent advance in nuclear magnetic resonance (NMR) microimaging has enabled in vivo cerebral blood volume (CBV) mapping with high spatial resolution. Using an intravascular susceptibility contrast agent and T 2-weighted magnetic resonance imaging (MRI) on a 9.4 T NMR microimager, the regional CBV was measured in mice as the transverse relaxation increase induced by the contrast agent. CBV maps in an Alzheimer's disease mouse model at resting state were obtained and examined. Four-month-old male transgenic mutant APP (V717F, K670N/M671L) mice (N = 10) and littermate wild-type controls (N = 12) were used. Regional analysis of the multi-slice CBV maps revealed statistically significant CBV reductions among the APP mice in cerebral cortex (-9.29%, P = 0.0002), hippocampus (-4.22%, P = 0.02), and thalamus (-5.21%, P = 0.03), indicating an early change of microvasculature in these selected regions. No significant difference was found in olfactory bulb, pons, midbrain, superior colliculus, medulla, and cerebellum. © 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subjectAD-
dc.subjectAlzheimer's disease-
dc.subjectBeta-amyloid-
dc.subjectCBV-
dc.subjectCerebral blood volume-
dc.subjectVascular-
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Volume - Geneticsen_US
dc.subject.meshBrain - Anatomy & Histology - Blood Supplyen_US
dc.subject.meshContrast Mediaen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Mutant Strainsen_US
dc.subject.meshMice, Transgenicen_US
dc.titleRegional cerebral blood volume reduction in transgenic mutant APP (V717F, K670N/M671L) miceen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neulet.2004.05.004en_US
dc.identifier.pmid15246553-
dc.identifier.scopuseid_2-s2.0-3042792348en_US
dc.identifier.hkuros109134-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3042792348&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume365en_US
dc.identifier.issue3en_US
dc.identifier.spage223en_US
dc.identifier.epage227en_US
dc.identifier.isiWOS:000222869500015-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridTang, H=36827331000en_US
dc.identifier.scopusauthoridAsai, T=55127277400en_US
dc.identifier.scopusauthoridYan, SD=12777106100en_US
dc.identifier.issnl0304-3940-

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