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- Publisher Website: 10.1046/j.0905-7161.2003.00930.x
- Scopus: eid_2-s2.0-0348111312
- PMID: 15015950
- WOS: WOS:000187107700010
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Article: Effect of bioresorbable fibres (Polyfibre®) and a bioresorbable foam (Polyfoam®) on new bone formation: A short term experimental study on the rabbit skull
Title | Effect of bioresorbable fibres (Polyfibre®) and a bioresorbable foam (Polyfoam®) on new bone formation: A short term experimental study on the rabbit skull |
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Authors | |
Keywords | Guided bone regeneration New bone formation Polylactic acid filler Polylactic acid membrane Rabbit Xenogenic bone substitute material |
Issue Date | 2003 |
Publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR |
Citation | Clinical Oral Implants Research, 2003, v. 14 n. 6, p. 734-742 How to Cite? |
Abstract | The aim of the study was to evaluate two bioresorbable polylactic acid (PLA) filler materials in a guided bone regeneration (GBR) model system. The first was Polyfibre®, a fibrous PLA filler material. Polyfoam®, the second material tested, consisted of a spongy PLA filler material. In each group there were eight rabbits. In test rabbits a flap was raised uncovering the calvaria. A hemispherical PLA dome was filled with Polyfibre® or Polyfoam® material and periphereal blood and anchored onto the calvaria. Eight rabbits with the same domes, filled with blood alone, served as controls. The rabbits were sacrificed at 1 or 2 months. Histomorphometric measurements of regenerated total tissue volume, bone height and bone volume were carried out in undecalcified sections under a light microscope. At 1 month the totally filled volume attained 87% (range 82-91) in the fibre group, including 25% (23-27) fibres, 87% (85-95) in the foam group, including 15% (15-16) foam, and 55% (16-100) in the controls. The volume of mineralized bone was 12% (7-15) in the fibre group, 15% (12-18) in the foam group and 6% (1-11) in control domes. Bone height attained 48% (27-79) in the fibre group, 37% (31-58) in the foam group and 45% (14-67) in the control group. At 2 months, tissue volume attained 86% (85-87) including 26% (22-29) fibres, bone volume attained 13% (7-21) and bone height attained 56% (42-78) in the Polyfibre® group. In the Polyfoam® group, they were 83% (55-99) including 18% (15-19) foam, 13% (7-24) and 49% (29-74). In control domes, tissue volume was 82% (35-100), bone volume 20% (9-27) and bone height 86% (60-100). The Polyfibre® and Polyfoam® material was excellently integrated. No adverse reactions were found in the surrounding tissues. Direct bone apposition was observed onto the material. In conclusion, Polyfibre® and Polyfoam® material had a positive effect on initial bone and tissue formation but was a hindrance to increasing tissue volume, bone volume or bone height at 2 months compared to control specimens. The Polyfibre® and Polyfoam® material provoked no adverse reactions in the surrounding tissues and allowed for extensive angiogenesis. |
Persistent Identifier | http://hdl.handle.net/10722/154273 |
ISSN | 2023 Impact Factor: 4.8 2023 SCImago Journal Rankings: 1.865 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wallkamm, B | en_US |
dc.contributor.author | Schmid, J | en_US |
dc.contributor.author | Hämmerle, CHF | en_US |
dc.contributor.author | Gogolewski, S | en_US |
dc.contributor.author | Lang, NP | en_US |
dc.date.accessioned | 2012-08-08T08:24:20Z | - |
dc.date.available | 2012-08-08T08:24:20Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.citation | Clinical Oral Implants Research, 2003, v. 14 n. 6, p. 734-742 | en_US |
dc.identifier.issn | 0905-7161 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/154273 | - |
dc.description.abstract | The aim of the study was to evaluate two bioresorbable polylactic acid (PLA) filler materials in a guided bone regeneration (GBR) model system. The first was Polyfibre®, a fibrous PLA filler material. Polyfoam®, the second material tested, consisted of a spongy PLA filler material. In each group there were eight rabbits. In test rabbits a flap was raised uncovering the calvaria. A hemispherical PLA dome was filled with Polyfibre® or Polyfoam® material and periphereal blood and anchored onto the calvaria. Eight rabbits with the same domes, filled with blood alone, served as controls. The rabbits were sacrificed at 1 or 2 months. Histomorphometric measurements of regenerated total tissue volume, bone height and bone volume were carried out in undecalcified sections under a light microscope. At 1 month the totally filled volume attained 87% (range 82-91) in the fibre group, including 25% (23-27) fibres, 87% (85-95) in the foam group, including 15% (15-16) foam, and 55% (16-100) in the controls. The volume of mineralized bone was 12% (7-15) in the fibre group, 15% (12-18) in the foam group and 6% (1-11) in control domes. Bone height attained 48% (27-79) in the fibre group, 37% (31-58) in the foam group and 45% (14-67) in the control group. At 2 months, tissue volume attained 86% (85-87) including 26% (22-29) fibres, bone volume attained 13% (7-21) and bone height attained 56% (42-78) in the Polyfibre® group. In the Polyfoam® group, they were 83% (55-99) including 18% (15-19) foam, 13% (7-24) and 49% (29-74). In control domes, tissue volume was 82% (35-100), bone volume 20% (9-27) and bone height 86% (60-100). The Polyfibre® and Polyfoam® material was excellently integrated. No adverse reactions were found in the surrounding tissues. Direct bone apposition was observed onto the material. In conclusion, Polyfibre® and Polyfoam® material had a positive effect on initial bone and tissue formation but was a hindrance to increasing tissue volume, bone volume or bone height at 2 months compared to control specimens. The Polyfibre® and Polyfoam® material provoked no adverse reactions in the surrounding tissues and allowed for extensive angiogenesis. | en_US |
dc.language | eng | en_US |
dc.publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR | en_US |
dc.relation.ispartof | Clinical Oral Implants Research | en_US |
dc.subject | Guided bone regeneration | - |
dc.subject | New bone formation | - |
dc.subject | Polylactic acid filler | - |
dc.subject | Polylactic acid membrane | - |
dc.subject | Rabbit | - |
dc.subject | Xenogenic bone substitute material | - |
dc.subject.mesh | Absorbable Implants | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biocompatible Materials - Pharmacology | en_US |
dc.subject.mesh | Bone Regeneration - Drug Effects - Physiology | en_US |
dc.subject.mesh | Bone Substitutes - Pharmacology | en_US |
dc.subject.mesh | Lactic Acid - Pharmacology | en_US |
dc.subject.mesh | Osteogenesis - Drug Effects - Physiology | en_US |
dc.subject.mesh | Polymers - Pharmacology | en_US |
dc.subject.mesh | Rabbits | en_US |
dc.subject.mesh | Skull - Cytology - Drug Effects - Surgery | en_US |
dc.title | Effect of bioresorbable fibres (Polyfibre®) and a bioresorbable foam (Polyfoam®) on new bone formation: A short term experimental study on the rabbit skull | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lang, NP:nplang@hkucc.hku.hk | en_US |
dc.identifier.authority | Lang, NP=rp00031 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1046/j.0905-7161.2003.00930.x | en_US |
dc.identifier.pmid | 15015950 | - |
dc.identifier.scopus | eid_2-s2.0-0348111312 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0348111312&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 734 | en_US |
dc.identifier.epage | 742 | en_US |
dc.identifier.isi | WOS:000187107700010 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Wallkamm, B=6603265034 | en_US |
dc.identifier.scopusauthorid | Schmid, J=8419181200 | en_US |
dc.identifier.scopusauthorid | Hämmerle, CHF=7005331848 | en_US |
dc.identifier.scopusauthorid | Gogolewski, S=7004684875 | en_US |
dc.identifier.scopusauthorid | Lang, NP=7201577367 | en_US |
dc.identifier.issnl | 0905-7161 | - |