File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Scopus: eid_2-s2.0-0036777013
- PMID: 12401052
- WOS: WOS:000178708300011
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: The Correlation between Neovascularization and Bone Formation in the Condyle during Forward Mandibular Positioning
Title | The Correlation between Neovascularization and Bone Formation in the Condyle during Forward Mandibular Positioning |
---|---|
Authors | |
Keywords | Functional appliance therapy Mandibular condylar growth New bone formation Vascular Endothelial Growth Factor Vascularization |
Issue Date | 2002 |
Publisher | E H Angle Education and Research Foundation, Inc. The Journal's web site is located at http://www.angle.org/ |
Citation | Angle Orthodontist, 2002, v. 72 n. 5, p. 431-438 How to Cite? |
Abstract | The aim of the present study was to investigate the temporal pattern of expression of VEGF (Vascular Endothelial Growth Factor) and new bone formation in the condyle during forward mandibular positioning. The importance of vascularization during endochondral ossification was investigated during natural growth of the condyle and compared to that after forward mandibular positioning. The goal was to further our understanding of the cellular responses during functional appliance therapy with a view to extending the experiment into maturity. One hundred and fifty 35 days old Sprage-Dawley rats, 100 fitted with a bite-jumping appliance and 50 untreated, were divided into 10 groups. One group was sacrificed on each of experimental days 3, 7, 14, 21, 30, 33, 37, 44, 51 and 60 respectively. Sagittal sections were cut and stained with VEGF antibodies and Periodic acid and Schiff's reagent (PAS). Each section was quantitatively analyzed with a computer assisted analyzing program and the temporal sequence of expression of VEGF and new bone formation during natural growth and after mandibular forward positioning was compared. There was significant increase in both vascularization and mandibular bone growth upon forward mandibular positioning and the highest amount of both were expressed in the posterior region of the condyle. The highest acceleration of vascularization preceded that of new bone formation. Thus, forward mandibular positioning was found to solicit a sequence of cellular events leading to increased vascularization and subsequently new bone formation resulting in enhanced condylar growth. |
Persistent Identifier | http://hdl.handle.net/10722/154213 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 1.446 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rabie, ABM | en_HK |
dc.contributor.author | Leung, FYC | en_HK |
dc.contributor.author | Chayanupatkul, A | en_HK |
dc.contributor.author | Hägg, U | en_HK |
dc.date.accessioned | 2012-08-08T08:23:55Z | - |
dc.date.available | 2012-08-08T08:23:55Z | - |
dc.date.issued | 2002 | en_HK |
dc.identifier.citation | Angle Orthodontist, 2002, v. 72 n. 5, p. 431-438 | en_HK |
dc.identifier.issn | 0003-3219 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/154213 | - |
dc.description.abstract | The aim of the present study was to investigate the temporal pattern of expression of VEGF (Vascular Endothelial Growth Factor) and new bone formation in the condyle during forward mandibular positioning. The importance of vascularization during endochondral ossification was investigated during natural growth of the condyle and compared to that after forward mandibular positioning. The goal was to further our understanding of the cellular responses during functional appliance therapy with a view to extending the experiment into maturity. One hundred and fifty 35 days old Sprage-Dawley rats, 100 fitted with a bite-jumping appliance and 50 untreated, were divided into 10 groups. One group was sacrificed on each of experimental days 3, 7, 14, 21, 30, 33, 37, 44, 51 and 60 respectively. Sagittal sections were cut and stained with VEGF antibodies and Periodic acid and Schiff's reagent (PAS). Each section was quantitatively analyzed with a computer assisted analyzing program and the temporal sequence of expression of VEGF and new bone formation during natural growth and after mandibular forward positioning was compared. There was significant increase in both vascularization and mandibular bone growth upon forward mandibular positioning and the highest amount of both were expressed in the posterior region of the condyle. The highest acceleration of vascularization preceded that of new bone formation. Thus, forward mandibular positioning was found to solicit a sequence of cellular events leading to increased vascularization and subsequently new bone formation resulting in enhanced condylar growth. | en_HK |
dc.language | eng | en_US |
dc.publisher | E H Angle Education and Research Foundation, Inc. The Journal's web site is located at http://www.angle.org/ | en_HK |
dc.relation.ispartof | Angle Orthodontist | en_HK |
dc.subject | Functional appliance therapy | en_HK |
dc.subject | Mandibular condylar growth | en_HK |
dc.subject | New bone formation | en_HK |
dc.subject | Vascular Endothelial Growth Factor | en_HK |
dc.subject | Vascularization | en_HK |
dc.subject.mesh | Analysis Of Variance | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Chondrocytes - Pathology | en_US |
dc.subject.mesh | Endothelial Growth Factors - Analysis | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Image Processing, Computer-Assisted | en_US |
dc.subject.mesh | Immunohistochemistry | en_US |
dc.subject.mesh | Intercellular Signaling Peptides And Proteins - Analysis | en_US |
dc.subject.mesh | Lymphokines - Analysis | en_US |
dc.subject.mesh | Mandible - Growth & Development - Pathology - Physiology | en_US |
dc.subject.mesh | Mandibular Condyle - Blood Supply - Growth & Development - Physiology | en_US |
dc.subject.mesh | Neovascularization, Physiologic - Physiology | en_US |
dc.subject.mesh | Orthodontic Appliance Design | en_US |
dc.subject.mesh | Orthodontic Appliances, Functional | en_US |
dc.subject.mesh | Osteogenesis - Physiology | en_US |
dc.subject.mesh | Periodic Acid-Schiff Reaction | en_US |
dc.subject.mesh | Protein Isoforms - Analysis | en_US |
dc.subject.mesh | Random Allocation | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Statistics As Topic | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.subject.mesh | Vascular Endothelial Growth Factor A | en_US |
dc.subject.mesh | Vascular Endothelial Growth Factors | en_US |
dc.title | The Correlation between Neovascularization and Bone Formation in the Condyle during Forward Mandibular Positioning | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Rabie, ABM: rabie@hku.hk | en_HK |
dc.identifier.email | Hägg, U: euohagg@hkusua.hku.hk | en_HK |
dc.identifier.authority | Rabie, ABM=rp00029 | en_HK |
dc.identifier.authority | Hägg, U=rp00020 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 12401052 | - |
dc.identifier.scopus | eid_2-s2.0-0036777013 | en_HK |
dc.identifier.hkuros | 76138 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0036777013&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 72 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 431 | en_HK |
dc.identifier.epage | 438 | en_HK |
dc.identifier.isi | WOS:000178708300011 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Rabie, ABM=7007172734 | en_HK |
dc.identifier.scopusauthorid | Leung, FYC=36103875400 | en_HK |
dc.identifier.scopusauthorid | Chayanupatkul, A=6506338362 | en_HK |
dc.identifier.scopusauthorid | Hägg, U=7006790279 | en_HK |
dc.identifier.issnl | 0003-3219 | - |