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Article: Interferon dysregulation and virus-induced cell death in avian influenza H5N1 virus infections.

TitleInterferon dysregulation and virus-induced cell death in avian influenza H5N1 virus infections.
Authors
Lee, DCLaw, AHHui, KTam, AHPeiris, JSLau, AS
Issue Date2012
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal, 2012, v. 18 suppl. 2, p. 12-16 How to Cite?
Abstract1. Hyper-induction of cytokines and chemokines was found in human blood macrophages infected with the avian influenza H5N1 and H9N2/G1 viruses, as compared to those infected with human influenza H1N1 virus. 2. IRF3 played a significant role in the hyperinduction of cytokines including IFN-β, IFN-λ1,IFN-α subtypes, MCP-1, and TNF-α, and also played a part in subsequent cytokine-induced cell signalling cascades. 3. Compared with H1N1 viruses, avian influenza viruses including H5N1/97 and its precursors triggered a caspase-mediated but delayed apoptotic response in human macrophages. 4. Therapies that can minimise immunopathology-associated dysregulation of innate immunity without impairing effective host defence may be valuable adjuncts to antiviral therapy.
Persistent Identifierhttp://hdl.handle.net/10722/152777
ISSN
1024-2708
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 0.261

 

DC FieldValueLanguage
dc.contributor.authorLee, DCen_HK
dc.contributor.authorLaw, AHen_HK
dc.contributor.authorHui, Ken_HK
dc.contributor.authorTam, AHen_HK
dc.contributor.authorPeiris, JSen_HK
dc.contributor.authorLau, ASen_HK
dc.date.accessioned2012-07-16T09:48:02Z-
dc.date.available2012-07-16T09:48:02Z-
dc.date.issued2012en_HK
dc.identifier.citationHong Kong Medical Journal, 2012, v. 18 suppl. 2, p. 12-16en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152777-
dc.description.abstract1. Hyper-induction of cytokines and chemokines was found in human blood macrophages infected with the avian influenza H5N1 and H9N2/G1 viruses, as compared to those infected with human influenza H1N1 virus. 2. IRF3 played a significant role in the hyperinduction of cytokines including IFN-β, IFN-λ1,IFN-α subtypes, MCP-1, and TNF-α, and also played a part in subsequent cytokine-induced cell signalling cascades. 3. Compared with H1N1 viruses, avian influenza viruses including H5N1/97 and its precursors triggered a caspase-mediated but delayed apoptotic response in human macrophages. 4. Therapies that can minimise immunopathology-associated dysregulation of innate immunity without impairing effective host defence may be valuable adjuncts to antiviral therapy.en_HK
dc.languageengen_US
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong Medical Journalen_HK
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.en_US
dc.subject.meshApoptosis-
dc.subject.meshCytokines - biosynthesis - genetics-
dc.subject.meshInfluenza A Virus, H5N1 Subtype-
dc.subject.meshInfluenza, Human - metabolism-
dc.subject.meshInterferon Regulatory Factor-3 - genetics - metabolism-
dc.titleInterferon dysregulation and virus-induced cell death in avian influenza H5N1 virus infections.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=18 &issue=Suppl 2&spage=&epage=&date=2012&atitle=Interferon+dysregulation+and+virus-induced+cell+death+in+avian+influenza+H5N1+virus+infections.en_US
dc.identifier.emailPeiris, JS: malik@hkucc.hku.hken_HK
dc.identifier.emailLau, AS: asylau@hku.hken_HK
dc.identifier.authorityPeiris, JS=rp00410en_HK
dc.identifier.authorityLau, AS=rp00474en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.pmid22311354-
dc.identifier.scopuseid_2-s2.0-84861557680en_HK
dc.identifier.hkuros200846en_US
dc.identifier.volume18en_HK
dc.identifier.issuesuppl. 2-
dc.identifier.spage12en_HK
dc.identifier.epage16en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridLee, DC=55232829400en_HK
dc.identifier.scopusauthoridLaw, AH=8692488400en_HK
dc.identifier.scopusauthoridHui, K=24492032000en_HK
dc.identifier.scopusauthoridTam, AH=55232137700en_HK
dc.identifier.scopusauthoridPeiris, JS=7005486823en_HK
dc.identifier.scopusauthoridLau, AS=7202626202en_HK
dc.identifier.issnl1024-2708-

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