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Article: Protection of vascular endothelial cells from high glucose injury induced by quercetin
Title | Protection of vascular endothelial cells from high glucose injury induced by quercetin |
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Authors | |
Issue Date | 2002 |
Citation | Zhong Yao Cai = Zhongyaocai = Journal Of Chinese Medicinal Materials, 2002, v. 25 n. 4, p. 268-270 How to Cite? |
Abstract | OBJECTIVE: To evaluate the effects of quercetin on the high glucose-injured vascular endothelial cells (VECs). METHODS: Experiments were divided into control group, injured group and quercetin group. The cultured VECs were injured by high glucose. The proliferation of VECs was assessed by MTT assay. The amount of NO and lipid peroxidation (monitored as maloraldehyde, MDA) of VECs were assessed by fluorometric assay. The amount of lactate dehydrogenase (LDH) was assessed by spectrophotometric method. RESULTS: 10(-2), 10(-3), 10(-4), 10(-5) mg/ml quercetin increased the proliferation of high glucose-injured VECs. 10(-2), 10(-3) mg/ml quercetin reduced LDH release and MDA production, increased NO release. CONCLUSION: Quercetin can protect cultured VECs from being injured by high glucose. |
Persistent Identifier | http://hdl.handle.net/10722/151142 |
ISSN | 2020 SCImago Journal Rankings: 0.125 |
DC Field | Value | Language |
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dc.contributor.author | Li, G | en_US |
dc.contributor.author | Zhang, H | en_US |
dc.contributor.author | Li, Y | en_US |
dc.contributor.author | Wang, Y | en_US |
dc.date.accessioned | 2012-06-26T06:17:37Z | - |
dc.date.available | 2012-06-26T06:17:37Z | - |
dc.date.issued | 2002 | en_US |
dc.identifier.citation | Zhong Yao Cai = Zhongyaocai = Journal Of Chinese Medicinal Materials, 2002, v. 25 n. 4, p. 268-270 | en_US |
dc.identifier.issn | 1001-4454 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/151142 | - |
dc.description.abstract | OBJECTIVE: To evaluate the effects of quercetin on the high glucose-injured vascular endothelial cells (VECs). METHODS: Experiments were divided into control group, injured group and quercetin group. The cultured VECs were injured by high glucose. The proliferation of VECs was assessed by MTT assay. The amount of NO and lipid peroxidation (monitored as maloraldehyde, MDA) of VECs were assessed by fluorometric assay. The amount of lactate dehydrogenase (LDH) was assessed by spectrophotometric method. RESULTS: 10(-2), 10(-3), 10(-4), 10(-5) mg/ml quercetin increased the proliferation of high glucose-injured VECs. 10(-2), 10(-3) mg/ml quercetin reduced LDH release and MDA production, increased NO release. CONCLUSION: Quercetin can protect cultured VECs from being injured by high glucose. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | en_US |
dc.subject.mesh | Antioxidants - Pharmacology | en_US |
dc.subject.mesh | Cells, Cultured | en_US |
dc.subject.mesh | Drugs, Chinese Herbal - Pharmacology | en_US |
dc.subject.mesh | Endothelium, Vascular - Cytology - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Glucose | en_US |
dc.subject.mesh | L-Lactate Dehydrogenase - Metabolism | en_US |
dc.subject.mesh | Malondialdehyde - Metabolism | en_US |
dc.subject.mesh | Nitric Oxide - Metabolism | en_US |
dc.subject.mesh | Quercetin - Pharmacology | en_US |
dc.title | Protection of vascular endothelial cells from high glucose injury induced by quercetin | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, Y:yiliang@hkucc.hku.hk | en_US |
dc.identifier.authority | Li, Y=rp01354 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 12583178 | - |
dc.identifier.scopus | eid_2-s2.0-1542441005 | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 268 | en_US |
dc.identifier.epage | 270 | en_US |
dc.identifier.scopusauthorid | Li, G=15135942300 | en_US |
dc.identifier.scopusauthorid | Zhang, H=16306030700 | en_US |
dc.identifier.scopusauthorid | Li, Y=27171876700 | en_US |
dc.identifier.scopusauthorid | Wang, Y=12779283000 | en_US |
dc.identifier.issnl | 1001-4454 | - |