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- Publisher Website: 10.1016/0021-9150(95)05683-1
- Scopus: eid_2-s2.0-0030031024
- PMID: 8678924
- WOS: WOS:A1996TZ59600006
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Article: Lipoperoxidative injury to macrophages by oxidatively modified low density lipoprotein may play an important role in foam cell formation
Title | Lipoperoxidative injury to macrophages by oxidatively modified low density lipoprotein may play an important role in foam cell formation |
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Authors | |
Keywords | Foam cell High density lipoprotein Low density lipoprotein Malondialdehyde modification Mouse peritoneal macrophage Oxidative modification |
Issue Date | 1996 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis |
Citation | Atherosclerosis, 1996, v. 121 n. 1, p. 55-61 How to Cite? |
Abstract | Both oxidatively and malondialdehyde modified low density lipoprotein (Ox-LDL and MDA-LDL) could be recognized by the scavenger receptor and induce intracellular cholesteryl ester accumulation of macrophage. The cholesteryl ester accumulation caused by MDA-LDL could be largely cleared by high density lipoprotein (HDL 3), but that caused by Ox-LDL could not be. Further studies showed that Ox-LDL and MDA-LDL all could decrease the binding capacity of HDL, and increase intracellular thiobarbituric acid reactive substances (TEARS). When macrophages were first cultured with MDA-LDL and then in medium without LDL, the decreased binding capacity of HDL, was somewhat recovered and the intracellular TEARS did not increase any more. However, if macrophages were first cultured with Ox-LDL, the binding capacity of H DL 3 continued to decrease and intracellular TEARS continued to increase. There was a negative correlation (r = -0.81, P < 0.01) between the decreased binding capacity of HDL 3, and the increased intracellular TEARS caused by Ox-LDL. These results imply that lipid peroxidative injury to macrophages caused by Ox-LDL play an important role in foam cell formation. |
Persistent Identifier | http://hdl.handle.net/10722/150985 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.461 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, SX | en_US |
dc.contributor.author | Zhou, M | en_US |
dc.contributor.author | Chen, Y | en_US |
dc.contributor.author | Wen, WY | en_US |
dc.contributor.author | Sun, MJ | en_US |
dc.date.accessioned | 2012-06-26T06:15:31Z | - |
dc.date.available | 2012-06-26T06:15:31Z | - |
dc.date.issued | 1996 | en_US |
dc.identifier.citation | Atherosclerosis, 1996, v. 121 n. 1, p. 55-61 | en_US |
dc.identifier.issn | 0021-9150 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/150985 | - |
dc.description.abstract | Both oxidatively and malondialdehyde modified low density lipoprotein (Ox-LDL and MDA-LDL) could be recognized by the scavenger receptor and induce intracellular cholesteryl ester accumulation of macrophage. The cholesteryl ester accumulation caused by MDA-LDL could be largely cleared by high density lipoprotein (HDL 3), but that caused by Ox-LDL could not be. Further studies showed that Ox-LDL and MDA-LDL all could decrease the binding capacity of HDL, and increase intracellular thiobarbituric acid reactive substances (TEARS). When macrophages were first cultured with MDA-LDL and then in medium without LDL, the decreased binding capacity of HDL, was somewhat recovered and the intracellular TEARS did not increase any more. However, if macrophages were first cultured with Ox-LDL, the binding capacity of H DL 3 continued to decrease and intracellular TEARS continued to increase. There was a negative correlation (r = -0.81, P < 0.01) between the decreased binding capacity of HDL 3, and the increased intracellular TEARS caused by Ox-LDL. These results imply that lipid peroxidative injury to macrophages caused by Ox-LDL play an important role in foam cell formation. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis | en_US |
dc.relation.ispartof | Atherosclerosis | en_US |
dc.subject | Foam cell | - |
dc.subject | High density lipoprotein | - |
dc.subject | Low density lipoprotein | - |
dc.subject | Malondialdehyde modification | - |
dc.subject | Mouse peritoneal macrophage | - |
dc.subject | Oxidative modification | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cells, Cultured | en_US |
dc.subject.mesh | Cholesterol Esters - Metabolism | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Foam Cells - Cytology | en_US |
dc.subject.mesh | Lipid Peroxidation | en_US |
dc.subject.mesh | Lipoproteins, Hdl - Pharmacology | en_US |
dc.subject.mesh | Lipoproteins, Ldl - Pharmacology | en_US |
dc.subject.mesh | Macrophages, Peritoneal - Drug Effects | en_US |
dc.subject.mesh | Malondialdehyde - Pharmacology | en_US |
dc.subject.mesh | Membrane Proteins | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Oxidation-Reduction | en_US |
dc.subject.mesh | Receptors, Immunologic - Drug Effects | en_US |
dc.subject.mesh | Receptors, Lipoprotein | en_US |
dc.subject.mesh | Receptors, Scavenger | en_US |
dc.subject.mesh | Scavenger Receptors, Class B | en_US |
dc.subject.mesh | Thiobarbituric Acid Reactive Substances - Analysis | en_US |
dc.title | Lipoperoxidative injury to macrophages by oxidatively modified low density lipoprotein may play an important role in foam cell formation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Zhou, M:mfzhou@hkucc.hku.hk | en_US |
dc.identifier.authority | Zhou, M=rp00844 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0021-9150(95)05683-1 | en_US |
dc.identifier.pmid | 8678924 | - |
dc.identifier.scopus | eid_2-s2.0-0030031024 | en_US |
dc.identifier.volume | 121 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 55 | en_US |
dc.identifier.epage | 61 | en_US |
dc.identifier.isi | WOS:A1996TZ59600006 | - |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | Liu, SX=16747119900 | en_US |
dc.identifier.scopusauthorid | Zhou, M=7403506005 | en_US |
dc.identifier.scopusauthorid | Chen, Y=16745998900 | en_US |
dc.identifier.scopusauthorid | Wen, WY=36911569800 | en_US |
dc.identifier.scopusauthorid | Sun, MJ=16747776600 | en_US |
dc.identifier.issnl | 0021-9150 | - |