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- Publisher Website: 10.1007/s11515-011-1135-5
- Scopus: eid_2-s2.0-80053638243
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Article: Roles of histone ubiquitylation in DNA damage signaling
Title | Roles of histone ubiquitylation in DNA damage signaling |
---|---|
Authors | |
Keywords | Dna Damage Histone Ubiquitylation Rnf168 Rnf8 Ubiquitin Ligase |
Issue Date | 2011 |
Citation | Frontiers In Biology, 2011, v. 6 n. 5, p. 390-397 How to Cite? |
Abstract | Histone ubiquitylation has emerged as an important chromatin modification associated with DNA damage signaling and repair pathways. These histone marks, laid down by E3 ubiquitin ligases that include RNF8 and RNF168, decorate chromatin domains surrounding DNA double-strand breaks (DSBs). Recent work implicated ubiquitylated histones in orchestrating cell cycle checkpoints, DNA repair and gene transcription. Here we summarize recent advances that contribute to our current knowledge of the highly dynamic nature of DSB-associated histone ubiquitylation, and discuss major challenges ahead in understanding the versatility of ubiquitin conjugation in maintaining genome stability. © 2011 Higher Education Press and Springer-Verlag Berlin Heidelberg. |
Persistent Identifier | http://hdl.handle.net/10722/149769 |
ISSN | 2020 SCImago Journal Rankings: 0.344 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dong, SS | en_US |
dc.contributor.author | Huen, MSY | en_US |
dc.date.accessioned | 2012-06-26T05:58:19Z | - |
dc.date.available | 2012-06-26T05:58:19Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Frontiers In Biology, 2011, v. 6 n. 5, p. 390-397 | en_US |
dc.identifier.issn | 1674-7984 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/149769 | - |
dc.description.abstract | Histone ubiquitylation has emerged as an important chromatin modification associated with DNA damage signaling and repair pathways. These histone marks, laid down by E3 ubiquitin ligases that include RNF8 and RNF168, decorate chromatin domains surrounding DNA double-strand breaks (DSBs). Recent work implicated ubiquitylated histones in orchestrating cell cycle checkpoints, DNA repair and gene transcription. Here we summarize recent advances that contribute to our current knowledge of the highly dynamic nature of DSB-associated histone ubiquitylation, and discuss major challenges ahead in understanding the versatility of ubiquitin conjugation in maintaining genome stability. © 2011 Higher Education Press and Springer-Verlag Berlin Heidelberg. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Frontiers in Biology | en_US |
dc.subject | Dna Damage | en_US |
dc.subject | Histone Ubiquitylation | en_US |
dc.subject | Rnf168 | en_US |
dc.subject | Rnf8 | en_US |
dc.subject | Ubiquitin Ligase | en_US |
dc.title | Roles of histone ubiquitylation in DNA damage signaling | en_US |
dc.type | Article | en_US |
dc.identifier.email | Huen, MSY:huen.michael@hku.hk | en_US |
dc.identifier.authority | Huen, MSY=rp01336 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s11515-011-1135-5 | en_US |
dc.identifier.scopus | eid_2-s2.0-80053638243 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80053638243&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 390 | en_US |
dc.identifier.epage | 397 | en_US |
dc.identifier.scopusauthorid | Dong, SS=35788109500 | en_US |
dc.identifier.scopusauthorid | Huen, MSY=23004751500 | en_US |
dc.identifier.issnl | 1674-7984 | - |