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- Publisher Website: 10.1016/j.canlet.2007.04.014
- Scopus: eid_2-s2.0-34547965826
- PMID: 17582679
- WOS: WOS:000249676700006
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Article: Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases
Title | Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases |
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Authors | |
Keywords | Epstein-Barr virus Latent membrane protein 1 MAP kinases p53 Phosphorylation |
Issue Date | 2007 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet |
Citation | Cancer Letters, 2007, v. 255 n. 2, p. 219-231 How to Cite? |
Abstract | The Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1), an oncogenic protein, plays an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC). Phosphorylation of p53 protein is likely to play the key role in regulating its activity. p53 protein accumulates but mutation of p53 gene is not common in NPC. The molecular mechanisms of p53 augmentation have not been completely elucidated. Here, the role of MAP kinases in the phosphorylation of p53 modulated by LMP1 was determined. p53 could be activated and phosphorylated clearly at Ser15, Ser20, Ser392, and Thr81 modulated by LMP1. Furthermore, LMP1-induced phosphorylation of p53 at Ser15 was directly by ERKs; at Ser20 and Thr81 by JNK, at Ser 15 and Ser392 by p38 kinase. The phosphorylation of p53 was associated with its transcriptional activity and stability modulated by LMP1. These results strongly suggest that MAP kinases have a direct role in LMP1-induced phosphorylation of p53 at multiple sites, which provide a novel view for us to understand the mechanism of the activation of p53 in the carcinogenesis of nasopharyngeal carcinoma. © 2007 Elsevier Ireland Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/149674 |
ISSN | 2023 Impact Factor: 9.1 2023 SCImago Journal Rankings: 2.595 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, L | en_US |
dc.contributor.author | Guo, L | en_US |
dc.contributor.author | Tao, Y | en_US |
dc.contributor.author | Zhou, S | en_US |
dc.contributor.author | Wang, Z | en_US |
dc.contributor.author | Luo, W | en_US |
dc.contributor.author | Hu, D | en_US |
dc.contributor.author | Li, Z | en_US |
dc.contributor.author | Xiao, L | en_US |
dc.contributor.author | Tang, M | en_US |
dc.contributor.author | Yi, W | en_US |
dc.contributor.author | Tsao, SW | en_US |
dc.contributor.author | Cao, Y | en_US |
dc.date.accessioned | 2012-06-26T05:56:54Z | - |
dc.date.available | 2012-06-26T05:56:54Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Cancer Letters, 2007, v. 255 n. 2, p. 219-231 | en_US |
dc.identifier.issn | 0304-3835 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/149674 | - |
dc.description.abstract | The Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1), an oncogenic protein, plays an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC). Phosphorylation of p53 protein is likely to play the key role in regulating its activity. p53 protein accumulates but mutation of p53 gene is not common in NPC. The molecular mechanisms of p53 augmentation have not been completely elucidated. Here, the role of MAP kinases in the phosphorylation of p53 modulated by LMP1 was determined. p53 could be activated and phosphorylated clearly at Ser15, Ser20, Ser392, and Thr81 modulated by LMP1. Furthermore, LMP1-induced phosphorylation of p53 at Ser15 was directly by ERKs; at Ser20 and Thr81 by JNK, at Ser 15 and Ser392 by p38 kinase. The phosphorylation of p53 was associated with its transcriptional activity and stability modulated by LMP1. These results strongly suggest that MAP kinases have a direct role in LMP1-induced phosphorylation of p53 at multiple sites, which provide a novel view for us to understand the mechanism of the activation of p53 in the carcinogenesis of nasopharyngeal carcinoma. © 2007 Elsevier Ireland Ltd. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet | en_US |
dc.relation.ispartof | Cancer Letters | en_US |
dc.subject | Epstein-Barr virus | - |
dc.subject | Latent membrane protein 1 | - |
dc.subject | MAP kinases | - |
dc.subject | p53 | - |
dc.subject | Phosphorylation | - |
dc.subject.mesh | Cell Line, Tumor | en_US |
dc.subject.mesh | Epstein-Barr Virus Infections - Metabolism | en_US |
dc.subject.mesh | Herpesvirus 4, Human - Metabolism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Mitogen-Activated Protein Kinases - Physiology | en_US |
dc.subject.mesh | Nasopharyngeal Neoplasms - Virology | en_US |
dc.subject.mesh | Phosphorylation | en_US |
dc.subject.mesh | Serine - Metabolism | en_US |
dc.subject.mesh | Threonine - Metabolism | en_US |
dc.subject.mesh | Tumor Suppressor Protein P53 - Metabolism | en_US |
dc.subject.mesh | Viral Matrix Proteins - Metabolism | en_US |
dc.title | Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tsao, SW:gswtsao@hkucc.hku.hk | en_US |
dc.identifier.authority | Tsao, SW=rp00399 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.canlet.2007.04.014 | en_US |
dc.identifier.pmid | 17582679 | - |
dc.identifier.scopus | eid_2-s2.0-34547965826 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-34547965826&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 255 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 219 | en_US |
dc.identifier.epage | 231 | en_US |
dc.identifier.isi | WOS:000249676700006 | - |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | Li, L=26662260500 | en_US |
dc.identifier.scopusauthorid | Guo, L=35083512700 | en_US |
dc.identifier.scopusauthorid | Tao, Y=7402420317 | en_US |
dc.identifier.scopusauthorid | Zhou, S=16687258000 | en_US |
dc.identifier.scopusauthorid | Wang, Z=18937718400 | en_US |
dc.identifier.scopusauthorid | Luo, W=36114068500 | en_US |
dc.identifier.scopusauthorid | Hu, D=15764988700 | en_US |
dc.identifier.scopusauthorid | Li, Z=8219788700 | en_US |
dc.identifier.scopusauthorid | Xiao, L=18938029700 | en_US |
dc.identifier.scopusauthorid | Tang, M=54409388100 | en_US |
dc.identifier.scopusauthorid | Yi, W=36115760400 | en_US |
dc.identifier.scopusauthorid | Tsao, SW=7102813116 | en_US |
dc.identifier.scopusauthorid | Cao, Y=7404524499 | en_US |
dc.identifier.issnl | 0304-3835 | - |