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Article: Distinct type-2A protein phosphatases activate HMGCoA reductase and acetyl-CoA carboxylase in liver

TitleDistinct type-2A protein phosphatases activate HMGCoA reductase and acetyl-CoA carboxylase in liver
Authors
Gaussin, VSkarlas, PChing, YPHardie, DGHue, L
KeywordsAcetyl-CoA carboxylase
AMP-activated protein kinase
Glutamine
HMGCoA reductase
Protein phosphatase-2A
Issue Date1997
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
Febs Letters, 1997, v. 413 n. 1, p. 115-118 How to Cite?
DOI: http://dx.doi.org/10.1016/S0014-5793(97)00890-9
AbstractAcetyl-CoA carboxylase and HMGCoA reductase are inactivated by the same AMP-activated protein kinase and are activated by type-2A protein phosphatase. To determine whether the same species of protein phosphatase-2A were involved, we studied the interconversion of acetyl-CoA carboxylase and HMGCoA reductase in isolated rat hepatocytes. We show that (i) these enzymes are differently regulated in hepatocytes and (ii) the species of type-2A protein phosphatase involved in their activation are different and can be separated by anion-exchange chromatography.
Persistent Identifierhttp://hdl.handle.net/10722/149561
ISSN
0014-5793
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 1.208
ISI Accession Number ID
WOS:A1997XT08400022
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorGaussin, Ven_US
dc.contributor.authorSkarlas, Pen_US
dc.contributor.authorChing, YPen_US
dc.contributor.authorHardie, DGen_US
dc.contributor.authorHue, Len_US
dc.date.accessioned2012-06-26T05:55:17Z-
dc.date.available2012-06-26T05:55:17Z-
dc.date.issued1997en_US
dc.identifier.citationFebs Letters, 1997, v. 413 n. 1, p. 115-118en_US
dc.identifier.issn0014-5793en_US
dc.identifier.urihttp://hdl.handle.net/10722/149561-
dc.description.abstractAcetyl-CoA carboxylase and HMGCoA reductase are inactivated by the same AMP-activated protein kinase and are activated by type-2A protein phosphatase. To determine whether the same species of protein phosphatase-2A were involved, we studied the interconversion of acetyl-CoA carboxylase and HMGCoA reductase in isolated rat hepatocytes. We show that (i) these enzymes are differently regulated in hepatocytes and (ii) the species of type-2A protein phosphatase involved in their activation are different and can be separated by anion-exchange chromatography.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_US
dc.relation.ispartofFEBS Lettersen_US
dc.subjectAcetyl-CoA carboxylase-
dc.subjectAMP-activated protein kinase-
dc.subjectGlutamine-
dc.subjectHMGCoA reductase-
dc.subjectProtein phosphatase-2A-
dc.subject.meshAmp-Activated Protein Kinasesen_US
dc.subject.meshAcetyl-Coa Carboxylase - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Hypoxiaen_US
dc.subject.meshChromatographyen_US
dc.subject.meshEnzyme Activationen_US
dc.subject.meshGlutamine - Pharmacologyen_US
dc.subject.meshHydroxymethylglutaryl Coa Reductases - Metabolismen_US
dc.subject.meshLiver - Drug Effects - Enzymologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMultienzyme Complexes - Metabolismen_US
dc.subject.meshPhosphoprotein Phosphatases - Metabolismen_US
dc.subject.meshProtein Kinases - Metabolismen_US
dc.subject.meshProtein Phosphatase 2en_US
dc.subject.meshProtein-Serine-Threonine Kinasesen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshTime Factorsen_US
dc.titleDistinct type-2A protein phosphatases activate HMGCoA reductase and acetyl-CoA carboxylase in liveren_US
dc.typeArticleen_US
dc.identifier.emailChing, YP:ypching@hku.hken_US
dc.identifier.authorityChing, YP=rp00469en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0014-5793(97)00890-9en_US
dc.identifier.pmid9287127-
dc.identifier.scopuseid_2-s2.0-0030840667en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030840667&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume413en_US
dc.identifier.issue1en_US
dc.identifier.spage115en_US
dc.identifier.epage118en_US
dc.identifier.isiWOS:A1997XT08400022-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridGaussin, V=6602467247en_US
dc.identifier.scopusauthoridSkarlas, P=6504513845en_US
dc.identifier.scopusauthoridChing, YP=7005431277en_US
dc.identifier.scopusauthoridHardie, DG=24373207900en_US
dc.identifier.scopusauthoridHue, L=7006578984en_US
dc.identifier.issnl0014-5793-

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