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- Publisher Website: 10.1002/1097-0142(19951215)76:12<2443::AID-CNCR2820761207>3.0.CO;2-F
- Scopus: eid_2-s2.0-0028845813
- PMID: 8625069
- WOS: WOS:A1995TJ10600006
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Article: Prognostic significance of pathologic features of hepatocellular carcinoma: a multivariate analysis of 278 patients
Title | Prognostic significance of pathologic features of hepatocellular carcinoma: a multivariate analysis of 278 patients |
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Authors | |
Keywords | hepatocellular carcinoma pathologic features prognosis tumor recurrence |
Issue Date | 1995 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741 |
Citation | Cancer, 1995, v. 76 n. 12, p. 2443-2448 How to Cite? |
Abstract | Background. In patients with hepatocellular carcinoma, surgical resection may offer a chance of cure. However, tumor recurrence is not infrequent after resection. Methods. To identify the pathologic factors that are of prognostic significance and predictive value in tumor recurrence, the authors studied 278 patients (243 men, 35 women) who had hepatectomy for hepatocellular carcinoma. Disease free and actuarial survival were correlated with 20 pathologic parameters of the resected specimens using multivariate analysis. Results. The median follow-up period was 23.6 months. The overall disease free survival rates at 1, 3 and 5 years were 42%, 23%, and 17%, respectively, and the overall actuarial survival rates for the corresponding time periods were 70%, 39%, and 28%, respectively. The results indicated that tumor encapsulation (P = 0.004) and heavy intratumor inflammatory infiltrates (P = 0.003) were independent favorable factors related to tumor recurrence. Negative resection margins (P = 0.001) and heavy intratumor inflammatory infiltrates (P = 0.003) were independent favorable factors correlated with survival. Conclusions. From this analysis, it was determined that detailed histologic examination of resected specimens of hepatocellular carcinoma is important in assessing long term prognosis and stratification of patients for treatment. |
Persistent Identifier | http://hdl.handle.net/10722/148034 |
ISSN | 2023 Impact Factor: 6.1 2023 SCImago Journal Rankings: 2.887 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ng, IOL | en_HK |
dc.contributor.author | Lai, ECS | en_HK |
dc.contributor.author | Fan, ST | en_HK |
dc.contributor.author | Ng, MMT | en_HK |
dc.contributor.author | So, MKP | en_HK |
dc.date.accessioned | 2012-05-29T06:10:30Z | - |
dc.date.available | 2012-05-29T06:10:30Z | - |
dc.date.issued | 1995 | en_HK |
dc.identifier.citation | Cancer, 1995, v. 76 n. 12, p. 2443-2448 | en_HK |
dc.identifier.issn | 0008-543X | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/148034 | - |
dc.description.abstract | Background. In patients with hepatocellular carcinoma, surgical resection may offer a chance of cure. However, tumor recurrence is not infrequent after resection. Methods. To identify the pathologic factors that are of prognostic significance and predictive value in tumor recurrence, the authors studied 278 patients (243 men, 35 women) who had hepatectomy for hepatocellular carcinoma. Disease free and actuarial survival were correlated with 20 pathologic parameters of the resected specimens using multivariate analysis. Results. The median follow-up period was 23.6 months. The overall disease free survival rates at 1, 3 and 5 years were 42%, 23%, and 17%, respectively, and the overall actuarial survival rates for the corresponding time periods were 70%, 39%, and 28%, respectively. The results indicated that tumor encapsulation (P = 0.004) and heavy intratumor inflammatory infiltrates (P = 0.003) were independent favorable factors related to tumor recurrence. Negative resection margins (P = 0.001) and heavy intratumor inflammatory infiltrates (P = 0.003) were independent favorable factors correlated with survival. Conclusions. From this analysis, it was determined that detailed histologic examination of resected specimens of hepatocellular carcinoma is important in assessing long term prognosis and stratification of patients for treatment. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741 | en_HK |
dc.relation.ispartof | Cancer | en_HK |
dc.rights | Cancer. Copyright © John Wiley & Sons, Inc. | - |
dc.subject | hepatocellular carcinoma | en_HK |
dc.subject | pathologic features | en_HK |
dc.subject | prognosis | en_HK |
dc.subject | tumor recurrence | en_HK |
dc.subject.mesh | Actuarial Analysis | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Carcinoma, Hepatocellular - Pathology - Surgery | en_US |
dc.subject.mesh | Disease-Free Survival | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Hepatectomy | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Liver Neoplasms - Pathology - Surgery | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Multivariate Analysis | en_US |
dc.subject.mesh | Neoplasm Recurrence, Local | en_US |
dc.subject.mesh | Predictive Value Of Tests | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Survival Analysis | en_US |
dc.subject.mesh | Treatment Outcome | en_US |
dc.title | Prognostic significance of pathologic features of hepatocellular carcinoma: a multivariate analysis of 278 patients | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Ng, IOL: iolng@hkucc.hku.hk | en_HK |
dc.identifier.email | Lai, ECS: ecslai@HKUCC.hku.hk | en_HK |
dc.identifier.email | Fan, ST: stfan@hku.hk | - |
dc.identifier.authority | Ng, IOL=rp00335 | en_HK |
dc.identifier.authority | Fan, ST=rp00355 | en_HK |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1002/1097-0142(19951215)76:12<2443::AID-CNCR2820761207>3.0.CO;2-F | en_HK |
dc.identifier.pmid | 8625069 | - |
dc.identifier.scopus | eid_2-s2.0-0028845813 | en_HK |
dc.identifier.hkuros | 9747 | - |
dc.identifier.hkuros | 10590 | - |
dc.identifier.volume | 76 | en_HK |
dc.identifier.issue | 12 | en_HK |
dc.identifier.spage | 2443 | en_HK |
dc.identifier.epage | 2448 | en_HK |
dc.identifier.isi | WOS:A1995TJ10600006 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Ng, IOL=7102753722 | en_HK |
dc.identifier.scopusauthorid | Lai, ECS=55187430500 | en_HK |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_HK |
dc.identifier.scopusauthorid | Ng, MMT=7202076310 | en_HK |
dc.identifier.scopusauthorid | So, MKP=36719004700 | en_HK |
dc.customcontrol.immutable | sml 130703 | - |
dc.identifier.issnl | 0008-543X | - |