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Article: Helicases as antiviral drug targets.

TitleHelicases as antiviral drug targets.
Authors
Huang, JDZheng, BJSun, HZ
Issue Date2008
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi, 2008, v. 14 Suppl 4, p. 36-38 How to Cite?
Abstract1. We have demonstrated for the first time that the helicase of a ribonucleic acid virus, the SARS coronavirus (SARS-CoV), is a valid target for drug development. 2. Using high throughput screen and chemical synthesis, several lead compounds targeting the SARS-CoV helicase have been identified. We have shown that these compounds can inhibit SARS-CoV helicase activity and viral growth in cell culture systems. These compounds can potentially be used to target other viruses.
Persistent Identifierhttp://hdl.handle.net/10722/147612
ISSN
1024-2708
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 0.261

 

DC FieldValueLanguage
dc.contributor.authorHuang, JDen_HK
dc.contributor.authorZheng, BJen_HK
dc.contributor.authorSun, HZen_HK
dc.date.accessioned2012-05-29T06:04:58Z-
dc.date.available2012-05-29T06:04:58Z-
dc.date.issued2008en_HK
dc.identifier.citationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi, 2008, v. 14 Suppl 4, p. 36-38en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147612-
dc.description.abstract1. We have demonstrated for the first time that the helicase of a ribonucleic acid virus, the SARS coronavirus (SARS-CoV), is a valid target for drug development. 2. Using high throughput screen and chemical synthesis, several lead compounds targeting the SARS-CoV helicase have been identified. We have shown that these compounds can inhibit SARS-CoV helicase activity and viral growth in cell culture systems. These compounds can potentially be used to target other viruses.en_HK
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong medical journal = Xianggang yi xue za zhien_HK
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subject.meshAnimalsen_US
dc.subject.meshAntiviral Agents - Pharmacologyen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCercopithecus Aethiopsen_US
dc.subject.meshDna Helicases - Genetics - Pharmacologyen_US
dc.subject.meshDrug Delivery Systemsen_US
dc.subject.meshDrug Evaluation, Preclinicalen_US
dc.subject.meshSars Virus - Drug Effects - Geneticsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshSevere Acute Respiratory Syndrome - Drug Therapy - Genetics - Virologyen_US
dc.subject.meshVero Cells - Cytology - Drug Effectsen_US
dc.subject.meshVirus Replication - Drug Effects - Geneticsen_US
dc.titleHelicases as antiviral drug targets.en_HK
dc.typeArticleen_HK
dc.identifier.emailHuang, JD:jdhuang@hkucc.hku.hken_HK
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_HK
dc.identifier.emailSun, HZ:hsun@hkucc.hku.hken_HK
dc.identifier.authorityHuang, JD=rp00451en_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.identifier.authoritySun, HZ=rp00777en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.pmid18708673-
dc.identifier.scopuseid_2-s2.0-70449808450en_HK
dc.identifier.hkuros156456-
dc.identifier.volume14 Suppl 4en_HK
dc.identifier.spage36en_HK
dc.identifier.epage38en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridHuang, JD=8108660600en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK
dc.identifier.scopusauthoridSun, HZ=7404827446en_HK
dc.identifier.issnl1024-2708-

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