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Article: Lithium attenuates the effects of dynorphin A(1-13) on inositol 1,4,5-trisphosphate and intracellular Ca2+ in rat ventricular myocytes

TitleLithium attenuates the effects of dynorphin A(1-13) on inositol 1,4,5-trisphosphate and intracellular Ca2+ in rat ventricular myocytes
Authors
KeywordsCa2+
dynorphin A(1-13)
inositol 1,4,5-trisphosphate
ventricular myocyte
κ-opioid receptor
Issue Date1996
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1996, v. 59 n. 25-26, p. 2181-2186 How to Cite?
AbstractWhen rat ventricular myocytes were stimulated with dynorphin A(1-13), a transient and rapid increase followed by a sustained and prolonged elevation in the intracellular levels of inositol 1,4,5-trisphosphate {Ins(1,4,5)P3} was observed. The responses were dose-related and abolished by nor-binaltorphimine. In the presence of lithium and absence of extracellular free inositol, the initial rapid elevation in Ins(1,4,5)P3 remained the same, but the second phase of sustained and prolonged elevation was abolished. Under this condition, the elevation in cytosolic free Ca2+ ([Ca2+](i)) was reduced significantly although there was still a detectable elevation over a time period when the Ins(1,4,5)P3 was at the basal level. The responses in Ins(1,4,5)P3 and [Ca2+](i) were not affected by lithium when stimulation of ventricular myocytes with dynorphin A(1-13) was performed in the presence of extracellular inositol. The data suggest that in rat ventricular myocytes, the κ-opioid receptor agonist stimulated mobilization of [Ca2+](i) was mediated mainly by Ins(1,4,5)P3.
Persistent Identifierhttp://hdl.handle.net/10722/147410
ISSN
2023 Impact Factor: 5.2
2023 SCImago Journal Rankings: 1.257
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSheng, JZen_US
dc.contributor.authorWong, NSen_US
dc.contributor.authorTai, KKen_US
dc.contributor.authorWong, TMen_US
dc.date.accessioned2012-05-29T06:03:31Z-
dc.date.available2012-05-29T06:03:31Z-
dc.date.issued1996en_US
dc.identifier.citationLife Sciences, 1996, v. 59 n. 25-26, p. 2181-2186en_US
dc.identifier.issn0024-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/147410-
dc.description.abstractWhen rat ventricular myocytes were stimulated with dynorphin A(1-13), a transient and rapid increase followed by a sustained and prolonged elevation in the intracellular levels of inositol 1,4,5-trisphosphate {Ins(1,4,5)P3} was observed. The responses were dose-related and abolished by nor-binaltorphimine. In the presence of lithium and absence of extracellular free inositol, the initial rapid elevation in Ins(1,4,5)P3 remained the same, but the second phase of sustained and prolonged elevation was abolished. Under this condition, the elevation in cytosolic free Ca2+ ([Ca2+](i)) was reduced significantly although there was still a detectable elevation over a time period when the Ins(1,4,5)P3 was at the basal level. The responses in Ins(1,4,5)P3 and [Ca2+](i) were not affected by lithium when stimulation of ventricular myocytes with dynorphin A(1-13) was performed in the presence of extracellular inositol. The data suggest that in rat ventricular myocytes, the κ-opioid receptor agonist stimulated mobilization of [Ca2+](i) was mediated mainly by Ins(1,4,5)P3.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_US
dc.relation.ispartofLife Sciencesen_US
dc.subjectCa2+-
dc.subjectdynorphin A(1-13)-
dc.subjectinositol 1,4,5-trisphosphate-
dc.subjectventricular myocyte-
dc.subjectκ-opioid receptor-
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshDynorphins - Pharmacologyen_US
dc.subject.meshHeart Ventricles - Cytology - Drug Effects - Metabolismen_US
dc.subject.meshInositol 1,4,5-Trisphosphate - Metabolismen_US
dc.subject.meshLithium - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPeptide Fragments - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleLithium attenuates the effects of dynorphin A(1-13) on inositol 1,4,5-trisphosphate and intracellular Ca2+ in rat ventricular myocytesen_US
dc.typeArticleen_US
dc.identifier.emailWong, NS:nswong@hkucc.hku.hken_US
dc.identifier.authorityWong, NS=rp00340en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0024-3205(96)00575-9-
dc.identifier.pmid8950322en_US
dc.identifier.scopuseid_2-s2.0-0030589036en_US
dc.identifier.hkuros25882-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030589036&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume59en_US
dc.identifier.issue25-26en_US
dc.identifier.spage2181en_US
dc.identifier.epage2186en_US
dc.identifier.isiWOS:A1996VV35000009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSheng, JZ=36846286500en_US
dc.identifier.scopusauthoridWong, NS=7202836641en_US
dc.identifier.scopusauthoridTai, KK=25935339600en_US
dc.identifier.scopusauthoridWong, TM=7403531434en_US
dc.identifier.issnl0024-3205-

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