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- Publisher Website: 10.1002/neu.480240604
- Scopus: eid_2-s2.0-0027309573
- PMID: 8331337
- WOS: WOS:A1993LE15500003
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Article: Gene elav of Drosophila melanogaster: A prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans
Title | Gene elav of Drosophila melanogaster: A prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans |
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Authors | |
Keywords | Drosophila melanogaster elav post‐transcriptional regulation RNA binding proteins |
Issue Date | 1993 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31737 |
Citation | Journal Of Neurobiology, 1993, v. 24 n. 6, p. 723-739 How to Cite? |
Abstract | Regulated gene activity is crucial to the formation and function of the nervous system. It is well known that gene regulation can occur at the transcriptional, post-transcriptional, translational, and post-translational levels. In this review our focus has been on the post-transcriptional regulation in neurons and on neural-specific RNA binding proteins that may be involved in post-transcriptional modulation of gene activity. We have taken advantage of this opportunity to review our work on the elav gene of Drosophila melanogaster which encodes a neural-specific RNA binding protein and relate it to other members of this elav-like gene family. We report new data that suggests that elav is post-transcriptionally regulated and we demonstrate that below-threshold levels of ELAV protein severely affects neuronal differentiation. |
Persistent Identifier | http://hdl.handle.net/10722/147380 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yao, KM | en_US |
dc.contributor.author | Samson, ML | en_US |
dc.contributor.author | Reeves, R | en_US |
dc.contributor.author | White, K | en_US |
dc.date.accessioned | 2012-05-29T06:03:18Z | - |
dc.date.available | 2012-05-29T06:03:18Z | - |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Journal Of Neurobiology, 1993, v. 24 n. 6, p. 723-739 | en_US |
dc.identifier.issn | 0022-3034 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/147380 | - |
dc.description.abstract | Regulated gene activity is crucial to the formation and function of the nervous system. It is well known that gene regulation can occur at the transcriptional, post-transcriptional, translational, and post-translational levels. In this review our focus has been on the post-transcriptional regulation in neurons and on neural-specific RNA binding proteins that may be involved in post-transcriptional modulation of gene activity. We have taken advantage of this opportunity to review our work on the elav gene of Drosophila melanogaster which encodes a neural-specific RNA binding protein and relate it to other members of this elav-like gene family. We report new data that suggests that elav is post-transcriptionally regulated and we demonstrate that below-threshold levels of ELAV protein severely affects neuronal differentiation. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31737 | en_US |
dc.relation.ispartof | Journal of Neurobiology | en_US |
dc.subject | Drosophila melanogaster | - |
dc.subject | elav | - |
dc.subject | post‐transcriptional regulation | - |
dc.subject | RNA binding proteins | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Drosophila Melanogaster - Genetics | en_US |
dc.subject.mesh | Gene Expression Regulation | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Multigene Family | en_US |
dc.subject.mesh | Mutation | en_US |
dc.subject.mesh | Nerve Tissue Proteins - Genetics | en_US |
dc.subject.mesh | Neurons - Metabolism | en_US |
dc.subject.mesh | Rna, Messenger - Genetics | en_US |
dc.subject.mesh | Rna-Binding Proteins - Genetics | en_US |
dc.title | Gene elav of Drosophila melanogaster: A prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans | en_US |
dc.type | Article | en_US |
dc.identifier.email | Yao, KM:kmyao@hku.hk | en_US |
dc.identifier.authority | Yao, KM=rp00344 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/neu.480240604 | en_US |
dc.identifier.pmid | 8331337 | - |
dc.identifier.scopus | eid_2-s2.0-0027309573 | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 723 | en_US |
dc.identifier.epage | 739 | en_US |
dc.identifier.isi | WOS:A1993LE15500003 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Yao, KM=7403234578 | en_US |
dc.identifier.scopusauthorid | Samson, ML=7103252061 | en_US |
dc.identifier.scopusauthorid | Reeves, R=7202150664 | en_US |
dc.identifier.scopusauthorid | White, K=35569872100 | en_US |
dc.identifier.issnl | 0022-3034 | - |