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Article: A study of tissue plasminogen activator forms from human small intestine

TitleA study of tissue plasminogen activator forms from human small intestine
Authors
Wong, NSLau, HKF
Issue Date1990
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/15216543.asp
Citation
Biochemistry International, 1990, v. 20 n. 6, p. 1149-1159 How to Cite?
AbstractAt least two forms of plasminogen activators which crossreacted with antiserum against tissue plasminogen activator (tPA) have been found in human small intestine homogenates. One of these activities has very slow mobility on Sephadex G-200 and is presumably a degraded form of tPA. The other moved very fast and was dispersed on gel filtration matrices, and probably represents aggregates of tPA with some other materials. Whereas 1 M NaCl, 1% Triton X-100 or 1 M potassium thiocyanate was unable to break up these aggregates, the high molecular weight components co-migrating with tPA could be separated from tPA by 4 M guanidine-HCl.
Persistent Identifierhttp://hdl.handle.net/10722/147351
ISSN
0158-5231
ISI Accession Number ID
WOS:A1990DG18800017

 

DC FieldValueLanguage
dc.contributor.authorWong, NSen_US
dc.contributor.authorLau, HKFen_US
dc.date.accessioned2012-05-29T06:03:07Z-
dc.date.available2012-05-29T06:03:07Z-
dc.date.issued1990en_US
dc.identifier.citationBiochemistry International, 1990, v. 20 n. 6, p. 1149-1159en_US
dc.identifier.issn0158-5231en_US
dc.identifier.urihttp://hdl.handle.net/10722/147351-
dc.description.abstractAt least two forms of plasminogen activators which crossreacted with antiserum against tissue plasminogen activator (tPA) have been found in human small intestine homogenates. One of these activities has very slow mobility on Sephadex G-200 and is presumably a degraded form of tPA. The other moved very fast and was dispersed on gel filtration matrices, and probably represents aggregates of tPA with some other materials. Whereas 1 M NaCl, 1% Triton X-100 or 1 M potassium thiocyanate was unable to break up these aggregates, the high molecular weight components co-migrating with tPA could be separated from tPA by 4 M guanidine-HCl.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/15216543.aspen_US
dc.relation.ispartofBiochemistry Internationalen_US
dc.subject.meshChromatography, Ion Exchangeen_US
dc.subject.meshHumansen_US
dc.subject.meshIntestine, Small - Enzymologyen_US
dc.subject.meshIsoelectric Focusingen_US
dc.subject.meshKineticsen_US
dc.subject.meshTissue Plasminogen Activator - Analysis - Isolation & Purification - Metabolismen_US
dc.titleA study of tissue plasminogen activator forms from human small intestineen_US
dc.typeArticleen_US
dc.identifier.emailWong, NS:nswong@hkucc.hku.hken_US
dc.identifier.authorityWong, NS=rp00340en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2114874en_US
dc.identifier.scopuseid_2-s2.0-0025295186en_US
dc.identifier.volume20en_US
dc.identifier.issue6en_US
dc.identifier.spage1149en_US
dc.identifier.epage1159en_US
dc.identifier.isiWOS:A1990DG18800017-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridWong, NS=7202836641en_US
dc.identifier.scopusauthoridLau, HKF=24441020200en_US
dc.identifier.issnl0158-5231-

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