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- Publisher Website: 10.1007/s10985-004-5643-3
- Scopus: eid_2-s2.0-14944372464
- PMID: 15747593
- WOS: WOS:000227178100007
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Article: Pair chart test for an early survival difference
Title | Pair chart test for an early survival difference |
---|---|
Authors | |
Keywords | Early treatment effect Log-rank test Pair chart statistic Survival comparison |
Issue Date | 2005 |
Publisher | Springer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1380-7870 |
Citation | Lifetime Data Analysis, 2005, v. 11 n. 1, p. 117-129 How to Cite? |
Abstract | The log-rank test is commonly used in comparing survival distributions between treatment and control groups in clinical trials. However, in many studies, the treatment is only effective at the early stage of the trial. Especially when the two survival curves cross, the log-rank test has a low statistical power to show the survival difference. We propose a test statistic for detecting such an early difference between the two treatment arms. The new test has an intuitive geometric interpretation based on a pair chart and is shown to have more power than the log-rank test when the treatment effect only appears in the early phase of the study. This advantage is evaluated for finite sample sizes in simulation studies. Finally, the proposed method is illustrated with a real data example of patients with gastric cancer. © 2005 Springer Science+Business Media, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/146557 |
ISSN | 2023 Impact Factor: 1.2 2023 SCImago Journal Rankings: 1.079 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yin, G | en_HK |
dc.contributor.author | Zeng, D | en_HK |
dc.date.accessioned | 2012-05-02T08:36:59Z | - |
dc.date.available | 2012-05-02T08:36:59Z | - |
dc.date.issued | 2005 | en_HK |
dc.identifier.citation | Lifetime Data Analysis, 2005, v. 11 n. 1, p. 117-129 | en_HK |
dc.identifier.issn | 1380-7870 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/146557 | - |
dc.description.abstract | The log-rank test is commonly used in comparing survival distributions between treatment and control groups in clinical trials. However, in many studies, the treatment is only effective at the early stage of the trial. Especially when the two survival curves cross, the log-rank test has a low statistical power to show the survival difference. We propose a test statistic for detecting such an early difference between the two treatment arms. The new test has an intuitive geometric interpretation based on a pair chart and is shown to have more power than the log-rank test when the treatment effect only appears in the early phase of the study. This advantage is evaluated for finite sample sizes in simulation studies. Finally, the proposed method is illustrated with a real data example of patients with gastric cancer. © 2005 Springer Science+Business Media, Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | Springer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1380-7870 | en_HK |
dc.relation.ispartof | Lifetime Data Analysis | en_HK |
dc.subject | Early treatment effect | en_HK |
dc.subject | Log-rank test | en_HK |
dc.subject | Pair chart statistic | en_HK |
dc.subject | Survival comparison | en_HK |
dc.subject.mesh | Biometry | en_US |
dc.subject.mesh | Controlled Clinical Trials As Topic - Statistics & Numerical Data | en_US |
dc.subject.mesh | Data Interpretation, Statistical | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Models, Statistical | en_US |
dc.subject.mesh | Sensitivity And Specificity | en_US |
dc.subject.mesh | Statistics, Nonparametric | en_US |
dc.subject.mesh | Survival Analysis | en_US |
dc.title | Pair chart test for an early survival difference | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Yin, G: gyin@hku.hk | en_HK |
dc.identifier.authority | Yin, G=rp00831 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s10985-004-5643-3 | en_HK |
dc.identifier.pmid | 15747593 | - |
dc.identifier.scopus | eid_2-s2.0-14944372464 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-14944372464&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 11 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 117 | en_HK |
dc.identifier.epage | 129 | en_HK |
dc.identifier.isi | WOS:000227178100007 | - |
dc.publisher.place | Netherlands | en_HK |
dc.identifier.scopusauthorid | Yin, G=8725807500 | en_HK |
dc.identifier.scopusauthorid | Zeng, D=8725807700 | en_HK |
dc.identifier.citeulike | 107644 | - |
dc.identifier.issnl | 1380-7870 | - |