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Article: From understanding synaptic plasticity to the development of cognitive enhancers
Title | From understanding synaptic plasticity to the development of cognitive enhancers | ||||||||
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Authors | |||||||||
Keywords | Alzheimer's disease BDNF dendritic spines depression synaptic plasticity | ||||||||
Issue Date | 2011 | ||||||||
Publisher | Cambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PNP | ||||||||
Citation | International Journal Of Neuropsychopharmacology, 2011, v. 14 n. 9, p. 1247-1256 How to Cite? | ||||||||
Abstract | Accumulating evidence reveals that synaptic dysfunction precedes neuronal loss in neurodegenerative diseases such as Alzheimer's disease. Intriguingly, synaptic abnormality is also implicated in a myriad of psychiatric disorders including depression. In particular, alterations in spine density and morphology have been associated with aberrant synaptic activity in these diseased brains. Understanding the molecular mechanisms underlying the regulation of spine morphogenesis, synaptic function and plasticity under physiological and pathological conditions will therefore provide critical insights for the development of potential therapeutic agents against these diseases. Here we summarize existing knowledge on some of the molecular players in synaptic plasticity, and highlight how these findings from basic neuroscientific research aid in the identification of novel drug leads for the development of therapeutics. © 2011 CINP. | ||||||||
Persistent Identifier | http://hdl.handle.net/10722/145832 | ||||||||
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.525 | ||||||||
ISI Accession Number ID |
Funding Information: We thank Ka-Chun Lok for his excellent help in preparing the figures and Dr Amy Fu for critical reading of the manuscript. The study of N. Y. Ip and Z. H. Cheung was supported in part by the Research Grants Council of Hong Kong (HKUST 6431/06M, 661109, 661309 and 1/06C) and the Area of Excellence Scheme of the University Grants Committee (AoE/B-15/01) and the Hong Kong Jockey Club. N. Y. lp and Z. H. Cheung were Croucher Foundation Senior Research Fellow and Croucher Foundation Fellow, respectively. | ||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cheung, ZH | en_HK |
dc.contributor.author | Ip, NY | en_HK |
dc.date.accessioned | 2012-03-23T09:49:54Z | - |
dc.date.available | 2012-03-23T09:49:54Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | International Journal Of Neuropsychopharmacology, 2011, v. 14 n. 9, p. 1247-1256 | en_HK |
dc.identifier.issn | 1461-1457 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/145832 | - |
dc.description.abstract | Accumulating evidence reveals that synaptic dysfunction precedes neuronal loss in neurodegenerative diseases such as Alzheimer's disease. Intriguingly, synaptic abnormality is also implicated in a myriad of psychiatric disorders including depression. In particular, alterations in spine density and morphology have been associated with aberrant synaptic activity in these diseased brains. Understanding the molecular mechanisms underlying the regulation of spine morphogenesis, synaptic function and plasticity under physiological and pathological conditions will therefore provide critical insights for the development of potential therapeutic agents against these diseases. Here we summarize existing knowledge on some of the molecular players in synaptic plasticity, and highlight how these findings from basic neuroscientific research aid in the identification of novel drug leads for the development of therapeutics. © 2011 CINP. | en_HK |
dc.language | eng | en_US |
dc.publisher | Cambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PNP | en_HK |
dc.relation.ispartof | International Journal of Neuropsychopharmacology | en_HK |
dc.subject | Alzheimer's disease | en_HK |
dc.subject | BDNF | en_HK |
dc.subject | dendritic spines | en_HK |
dc.subject | depression | en_HK |
dc.subject | synaptic plasticity | en_HK |
dc.title | From understanding synaptic plasticity to the development of cognitive enhancers | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Cheung, ZH:zelda@hku.hk | en_HK |
dc.identifier.authority | Cheung, ZH=rp01588 | en_HK |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1017/S1461145710001537 | en_HK |
dc.identifier.scopus | eid_2-s2.0-84856069899 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84856069899&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 14 | en_HK |
dc.identifier.issue | 9 | en_HK |
dc.identifier.spage | 1247 | en_HK |
dc.identifier.epage | 1256 | en_HK |
dc.identifier.eissn | 1469-5111 | - |
dc.identifier.isi | WOS:000295434600009 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Cheung, ZH=6507483375 | en_HK |
dc.identifier.scopusauthorid | Ip, NY=35318021000 | en_HK |
dc.identifier.issnl | 1461-1457 | - |