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- Publisher Website: 10.1016/j.neulet.2003.12.117
- Scopus: eid_2-s2.0-2342634487
- PMID: 15135890
- WOS: WOS:000221566100014
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Article: Cdk5: Mediator of neuronal death and survival
Title | Cdk5: Mediator of neuronal death and survival |
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Authors | |
Keywords | Chemicals And Cas Registry Numbers: Cdk5 Protein, Human, Ec 2.7.1.37 Cdk5 Protein, Mouse, Ec 2.7.1.37 Cyclin-Dependent Kinase 5, Ec 2.7.1.37 Cyclin-Dependent Kinases, Ec 2.7.1.37 Nerve Tissue Proteins Neuronal Cdk5 Activator (P25-P35) Oncogene Proteins V-Erbb Proto-Oncogene Proteins C-Jun |
Issue Date | 2004 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet |
Citation | Neuroscience Letters, 2004, v. 361 n. 1-3, p. 47-51 How to Cite? |
Abstract | Cdk5 (cyclin-dependent kinase 5) is a serine/threonine kinase implicated to play pivotal roles in neuronal development. Recently, its potential involvement as a regulator of neuronal death and survival has attracted considerable interests. Importantly, increasing evidence has linked Cdk5 to the etiopathology of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. Here we summarize the recent findings on Cdk5 not only as an important participant in neuronal death, but also a key player in neuronal survival. Elucidating the mechanisms of regulation of Cdk5 and its downstream signaling might prove to be crucial in the therapeutic treatment of neurodegenerative diseases. © 2003 Elsevier Ireland Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/145827 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.745 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cheung, ZH | en_HK |
dc.contributor.author | Ip, NY | en_HK |
dc.date.accessioned | 2012-03-23T09:49:51Z | - |
dc.date.available | 2012-03-23T09:49:51Z | - |
dc.date.issued | 2004 | en_HK |
dc.identifier.citation | Neuroscience Letters, 2004, v. 361 n. 1-3, p. 47-51 | en_HK |
dc.identifier.issn | 0304-3940 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/145827 | - |
dc.description.abstract | Cdk5 (cyclin-dependent kinase 5) is a serine/threonine kinase implicated to play pivotal roles in neuronal development. Recently, its potential involvement as a regulator of neuronal death and survival has attracted considerable interests. Importantly, increasing evidence has linked Cdk5 to the etiopathology of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. Here we summarize the recent findings on Cdk5 not only as an important participant in neuronal death, but also a key player in neuronal survival. Elucidating the mechanisms of regulation of Cdk5 and its downstream signaling might prove to be crucial in the therapeutic treatment of neurodegenerative diseases. © 2003 Elsevier Ireland Ltd. All rights reserved. | en_HK |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet | en_HK |
dc.relation.ispartof | Neuroscience Letters | en_HK |
dc.subject | Chemicals And Cas Registry Numbers: Cdk5 Protein, Human, Ec 2.7.1.37 | en_US |
dc.subject | Cdk5 Protein, Mouse, Ec 2.7.1.37 | en_US |
dc.subject | Cyclin-Dependent Kinase 5, Ec 2.7.1.37 | en_US |
dc.subject | Cyclin-Dependent Kinases, Ec 2.7.1.37 | en_US |
dc.subject | Nerve Tissue Proteins | en_US |
dc.subject | Neuronal Cdk5 Activator (P25-P35) | en_US |
dc.subject | Oncogene Proteins V-Erbb | en_US |
dc.subject | Proto-Oncogene Proteins C-Jun | en_US |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Cell Death - genetics | en_HK |
dc.subject.mesh | Cell Survival - genetics | en_HK |
dc.subject.mesh | Cyclin-Dependent Kinase 5 | en_HK |
dc.subject.mesh | Cyclin-Dependent Kinases - genetics - metabolism | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Mice | en_HK |
dc.subject.mesh | Nerve Tissue Proteins - genetics - metabolism | en_HK |
dc.subject.mesh | Neurodegenerative Diseases - enzymology - genetics - physiopathology | en_HK |
dc.subject.mesh | Neurons - enzymology - metabolism | en_HK |
dc.subject.mesh | Oncogene Proteins v-erbB - genetics - metabolism | en_HK |
dc.subject.mesh | Proto-Oncogene Proteins c-jun - genetics - metabolism | en_HK |
dc.subject.mesh | Signal Transduction - genetics | en_HK |
dc.title | Cdk5: Mediator of neuronal death and survival | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Cheung, ZH:zelda@hku.hk | en_HK |
dc.identifier.authority | Cheung, ZH=rp01588 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.neulet.2003.12.117 | en_HK |
dc.identifier.pmid | 15135890 | - |
dc.identifier.scopus | eid_2-s2.0-2342634487 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-2342634487&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 361 | en_HK |
dc.identifier.issue | 1-3 | en_HK |
dc.identifier.spage | 47 | en_HK |
dc.identifier.epage | 51 | en_HK |
dc.identifier.isi | WOS:000221566100014 | - |
dc.publisher.place | Ireland | en_HK |
dc.identifier.scopusauthorid | Cheung, ZH=6507483375 | en_HK |
dc.identifier.scopusauthorid | Ip, NY=7005756760 | en_HK |
dc.identifier.citeulike | 276922 | - |
dc.identifier.issnl | 0304-3940 | - |