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Article: Cdk5: A multifaceted kinase in neurodegenerative diseases

TitleCdk5: A multifaceted kinase in neurodegenerative diseases
Authors
Cheung, ZHIp, NY
Issue Date2012
PublisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tcb
Citation
Trends In Cell Biology, 2012, v. 22 n. 3, p. 169-175 How to Cite?
DOI: http://dx.doi.org/10.1016/j.tcb.2011.11.003
AbstractSince the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of the Cdk family almost 20 years ago, deregulation of Cdk5 activity has been linked to an array of neurodegenerative diseases. As knowledge on the etiopathological mechanisms of these diseases evolved through the years, Cdk5 has also been implicated in additional cellular events that are affected under these pathological conditions. From the role of Cdk5 in the regulation of synaptic functions to its involvement in autophagy deregulation, significant insights have been obtained regarding the role of Cdk5 as a key regulator of neurodegeneration. Here, we summarize recent findings on the involvement of Cdk5 in the pathophysiological mechanisms underlying various neurodegenerative diseases. © 2011 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/145811
ISSN
0962-8924
2021 Impact Factor: 21.167
2020 SCImago Journal Rankings: 8.705
ISI Accession Number ID
WOS:000302447300006
Funding AgencyGrant Number
Research Grants Council of Hong KongHKUST 661007
660309
661109
660810
660210
University Grants CommitteeAoE/B-15/01
Hong Kong Jockey Club
Funding Information:

We apologize to the many researchers whose works were not cited because of space limitation. We thank Ka-Chun Lok for his help in preparing the figures. This study was supported in part by the Research Grants Council of Hong Kong (HKUST 661007, 660309, 661109, 660810 and 660210), the Area of Excellence Scheme of the University Grants Committee (AoE/B-15/01) and Hong Kong Jockey Club. N.Y. Ip and Z.H. Cheung are Croucher Foundation Senior Research Fellow and Croucher Foundation Fellow, respectively.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorCheung, ZHen_HK
dc.contributor.authorIp, NYen_HK
dc.date.accessioned2012-03-23T09:49:38Z-
dc.date.available2012-03-23T09:49:38Z-
dc.date.issued2012en_HK
dc.identifier.citationTrends In Cell Biology, 2012, v. 22 n. 3, p. 169-175en_HK
dc.identifier.issn0962-8924en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145811-
dc.description.abstractSince the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of the Cdk family almost 20 years ago, deregulation of Cdk5 activity has been linked to an array of neurodegenerative diseases. As knowledge on the etiopathological mechanisms of these diseases evolved through the years, Cdk5 has also been implicated in additional cellular events that are affected under these pathological conditions. From the role of Cdk5 in the regulation of synaptic functions to its involvement in autophagy deregulation, significant insights have been obtained regarding the role of Cdk5 as a key regulator of neurodegeneration. Here, we summarize recent findings on the involvement of Cdk5 in the pathophysiological mechanisms underlying various neurodegenerative diseases. © 2011 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tcben_HK
dc.relation.ispartofTrends in Cell Biologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAutophagyen_HK
dc.subject.meshCell Survivalen_HK
dc.subject.meshCyclin-Dependent Kinase 5 - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshNeurodegenerative Diseases - enzymology - pathology - physiopathologyen_HK
dc.subject.meshSignal Transductionen_HK
dc.titleCdk5: A multifaceted kinase in neurodegenerative diseasesen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ZH:zelda@hku.hken_HK
dc.identifier.authorityCheung, ZH=rp01588en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.tcb.2011.11.003en_HK
dc.identifier.pmid22189166-
dc.identifier.scopuseid_2-s2.0-84857781607en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857781607&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue3en_HK
dc.identifier.spage169en_HK
dc.identifier.epage175en_HK
dc.identifier.eissn1879-3088-
dc.identifier.isiWOS:000302447300006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, ZH=6507483375en_HK
dc.identifier.scopusauthoridIp, NY=35899235100en_HK
dc.identifier.citeulike10177175-
dc.identifier.issnl0962-8924-

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