File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.2174/1877382601003010095
- Find via
Supplementary
-
Citations:
- Appears in Collections:
Article: Revisit of the Cardiac Inward Rectifier Potassium Current IK1
Title | Revisit of the Cardiac Inward Rectifier Potassium Current IK1 |
---|---|
Authors | |
Keywords | Inward rectifier potassium channels Cardiac inward rectifier potassium current IK1 Mg2+ Polyamines |
Issue Date | 2010 |
Publisher | Bentham Open. The Journal's web site is located at http://www.bentham.org/open/tocvj/ |
Citation | The Open Circulation & Vascular Journal, 2010, v. 3, p. 95-102 How to Cite? |
Abstract | Inward rectifier potassium currents are present in different types of cells. In the heart, the inward rectifier
potassium current IK1 plays a crucial role in maintaining cardiac resting membrane potential and excitability. It is
generally believed that the strong inward rectification of cardiac IK1 channels makes it conduct substantial current near the resting potential but carry little or no current at depolarized potentials. However, recent studies in native cardiac myocytes and HEK 293 cell line stably expressing human Kir2.1 gene have demonstrated that a significant transient outward current carried by IK1 channels is activated by the upstroke of action potential. This review will revisit cardiac IK1 channels, especially the previously-ignored transient outward component of IK1 carried by Kir2.1 channels. |
Persistent Identifier | http://hdl.handle.net/10722/145794 |
ISSN |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, GR | - |
dc.contributor.author | Dong, MQ | - |
dc.date.accessioned | 2012-03-13T04:36:31Z | - |
dc.date.available | 2012-03-13T04:36:31Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | The Open Circulation & Vascular Journal, 2010, v. 3, p. 95-102 | - |
dc.identifier.issn | 1877-3826 | - |
dc.identifier.uri | http://hdl.handle.net/10722/145794 | - |
dc.description.abstract | Inward rectifier potassium currents are present in different types of cells. In the heart, the inward rectifier potassium current IK1 plays a crucial role in maintaining cardiac resting membrane potential and excitability. It is generally believed that the strong inward rectification of cardiac IK1 channels makes it conduct substantial current near the resting potential but carry little or no current at depolarized potentials. However, recent studies in native cardiac myocytes and HEK 293 cell line stably expressing human Kir2.1 gene have demonstrated that a significant transient outward current carried by IK1 channels is activated by the upstroke of action potential. This review will revisit cardiac IK1 channels, especially the previously-ignored transient outward component of IK1 carried by Kir2.1 channels. | - |
dc.language | eng | - |
dc.publisher | Bentham Open. The Journal's web site is located at http://www.bentham.org/open/tocvj/ | - |
dc.relation.ispartof | The Open Circulation & Vascular Journal | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Inward rectifier potassium channels | - |
dc.subject | Cardiac inward rectifier potassium current | - |
dc.subject | IK1 | - |
dc.subject | Mg2+ | - |
dc.subject | Polyamines | - |
dc.title | Revisit of the Cardiac Inward Rectifier Potassium Current IK1 | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, GR: grli@hkucc.hku.hk | - |
dc.identifier.email | Dong, MQ: dongmq@hku.hk | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.2174/1877382601003010095 | - |
dc.identifier.hkuros | 199000 | - |
dc.identifier.volume | 3 | - |
dc.identifier.spage | 95 | - |
dc.identifier.epage | 102 | - |
dc.publisher.place | Netherlands | - |
dc.identifier.issnl | 1877-3826 | - |