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- Publisher Website: 10.1046/j.0003-2409.2001.02446.x
- Scopus: eid_2-s2.0-0036192257
- PMID: 11879213
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Article: Propofol effective concentration 50 and its relationship to bispectral index
Title | Propofol effective concentration 50 and its relationship to bispectral index |
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Authors | |
Keywords | Anaesthetics, intravenous: propofol Brain: electroencephalography |
Issue Date | 2002 |
Publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2044 |
Citation | Anaesthesia, 2002, v. 57 n. 3, p. 242-248 How to Cite? |
Abstract | Sixty unpremedicated healthy adult patients were studied during induction of anaesthesia with intravenous propofol delivered by a 'Diprifusor' target-controlled infusion. Bispectral index (BIS) and spectral edge frequency (SEF95) were measured concurrently with the predicted blood and effect site propofol concentrations. Logistic regression was used to calculate the predicted propofol blood and effect site concentrations required to produce unconsciousness and no response to a noxious stimulus in 50% and 95% of patients and to correlate BIS with these end-points. The Diprifusor TCI software produces anaesthesia at consistent target concentrations. Bispectral index correlates well with clinical end-points and may be useful during propofol anaesthesia. |
Persistent Identifier | http://hdl.handle.net/10722/145523 |
ISSN | 2023 Impact Factor: 7.5 2023 SCImago Journal Rankings: 2.400 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Irwin, MG | en_HK |
dc.contributor.author | Hui, TWC | en_HK |
dc.contributor.author | Milne, SE | en_HK |
dc.contributor.author | Kenny, GNC | en_HK |
dc.date.accessioned | 2012-02-28T01:53:14Z | - |
dc.date.available | 2012-02-28T01:53:14Z | - |
dc.date.issued | 2002 | en_HK |
dc.identifier.citation | Anaesthesia, 2002, v. 57 n. 3, p. 242-248 | en_HK |
dc.identifier.issn | 0003-2409 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/145523 | - |
dc.description.abstract | Sixty unpremedicated healthy adult patients were studied during induction of anaesthesia with intravenous propofol delivered by a 'Diprifusor' target-controlled infusion. Bispectral index (BIS) and spectral edge frequency (SEF95) were measured concurrently with the predicted blood and effect site propofol concentrations. Logistic regression was used to calculate the predicted propofol blood and effect site concentrations required to produce unconsciousness and no response to a noxious stimulus in 50% and 95% of patients and to correlate BIS with these end-points. The Diprifusor TCI software produces anaesthesia at consistent target concentrations. Bispectral index correlates well with clinical end-points and may be useful during propofol anaesthesia. | en_HK |
dc.language | eng | en_US |
dc.publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2044 | en_HK |
dc.relation.ispartof | Anaesthesia | en_HK |
dc.rights | The definitive version is available at www3.interscience.wiley.com | en_US |
dc.subject | Anaesthetics, intravenous: propofol | - |
dc.subject | Brain: electroencephalography | - |
dc.subject.mesh | Anesthetics, Intravenous - administration and dosage - blood - pharmacology | en_HK |
dc.subject.mesh | Blood Pressure - drug effects | en_HK |
dc.subject.mesh | Drug Monitoring - methods | en_HK |
dc.subject.mesh | Electroencephalography - drug effects | en_HK |
dc.subject.mesh | Propofol - administration and dosage - blood - pharmacology | en_HK |
dc.title | Propofol effective concentration 50 and its relationship to bispectral index | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Irwin, MG: mgirwin@hkucc.hku.hk | en_HK |
dc.identifier.authority | Irwin, MG=rp00390 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1046/j.0003-2409.2001.02446.x | en_HK |
dc.identifier.pmid | 11879213 | - |
dc.identifier.scopus | eid_2-s2.0-0036192257 | en_HK |
dc.identifier.hkuros | 67247 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0036192257&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 57 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 242 | en_HK |
dc.identifier.epage | 248 | en_HK |
dc.identifier.isi | WOS:000174369500007 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.issnl | 0003-2409 | - |