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Article: Quantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CT

TitleQuantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CT
Authors
KeywordsADC
DWI
PET/CT
Primary rectal adenocarcinoma
SUV
TDI
TLG
Issue Date2011
PublisherSpringer New York LLC.
Citation
Molecular Imaging And Biology, 2011, v. 13 n. 5, p. 1020-1028 How to Cite?
AbstractPurpose: The aim of the study was to assess correlations between parameters on diffusionweighted imaging and 2-deoxy-2-[ 18F]fluoro-D-glucose- positron emission tomography/computed tomography (FDG-PET/CT) in rectal cancer. Procedures: Thirty-three consecutive patients with pathologically confirmed rectal adenocarcinoma were included in this study. Apparent diffusion coefficient (ADC) maps were generated to calculate ADC mean (average ADC), ADC min (lowest ADC), tumor volume, and total diffusivity index (TDI). PET/CT exams were performed within 1 week of magnetic resonance imaging. Standardized uptake values (SUVs) were normalized to the injected FDG dose and body weight. SUV max (maximum SUV), SUV mean (average SUV), tumor volume, and total lesion glycolysis (TLG) were calculated using a 50% threshold. Results: Significant negative correlations were found between ADC min and SUV max (r=-0.450, p=0.009), and between ADC mean and SUV mean (r=-0.402, p=0.020). A significant positive correlation was found between TDI and TLG (r=0.634, p<0.001). Conclusion: The significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma. © Academy of Molecular Imaging and Society for Molecular Imaging, 2010.
Persistent Identifierhttp://hdl.handle.net/10722/145099
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.752
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGu, Jen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorChan, Qen_HK
dc.contributor.authorLaw, Wen_HK
dc.contributor.authorZhang, Jen_HK
dc.date.accessioned2012-02-21T05:44:46Z-
dc.date.available2012-02-21T05:44:46Z-
dc.date.issued2011en_HK
dc.identifier.citationMolecular Imaging And Biology, 2011, v. 13 n. 5, p. 1020-1028en_HK
dc.identifier.issn1536-1632en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145099-
dc.description.abstractPurpose: The aim of the study was to assess correlations between parameters on diffusionweighted imaging and 2-deoxy-2-[ 18F]fluoro-D-glucose- positron emission tomography/computed tomography (FDG-PET/CT) in rectal cancer. Procedures: Thirty-three consecutive patients with pathologically confirmed rectal adenocarcinoma were included in this study. Apparent diffusion coefficient (ADC) maps were generated to calculate ADC mean (average ADC), ADC min (lowest ADC), tumor volume, and total diffusivity index (TDI). PET/CT exams were performed within 1 week of magnetic resonance imaging. Standardized uptake values (SUVs) were normalized to the injected FDG dose and body weight. SUV max (maximum SUV), SUV mean (average SUV), tumor volume, and total lesion glycolysis (TLG) were calculated using a 50% threshold. Results: Significant negative correlations were found between ADC min and SUV max (r=-0.450, p=0.009), and between ADC mean and SUV mean (r=-0.402, p=0.020). A significant positive correlation was found between TDI and TLG (r=0.634, p<0.001). Conclusion: The significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma. © Academy of Molecular Imaging and Society for Molecular Imaging, 2010.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC.en_US
dc.relation.ispartofMolecular Imaging and Biologyen_HK
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.en_US
dc.rightsThe Author(s)en_US
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectADCen_HK
dc.subjectDWIen_HK
dc.subjectPET/CTen_HK
dc.subjectPrimary rectal adenocarcinomaen_HK
dc.subjectSUVen_HK
dc.subjectTDIen_HK
dc.subjectTLGen_HK
dc.subject.meshFluorodeoxyglucose F18 - diagnostic use-
dc.subject.meshMagnetic Resonance Imaging - methods-
dc.subject.meshHumans-
dc.subject.meshPositron-Emission Tomography and Computed Tomography - methods-
dc.subject.meshRectal Neoplasms - diagnosis - pathology-
dc.titleQuantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CTen_HK
dc.typeArticleen_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailLaw, W: lawwl@hkucc.hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityLaw, W=rp00436en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s11307-010-0433-7en_HK
dc.identifier.pmid20872077-
dc.identifier.pmcidPMC3179585-
dc.identifier.scopuseid_2-s2.0-84855688291en_HK
dc.identifier.hkuros192107-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855688291&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1020en_HK
dc.identifier.epage1028en_HK
dc.identifier.eissn1860-2002en_US
dc.identifier.isiWOS:000295176200023-
dc.publisher.placeUnited Statesen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridGu, J=7403129372en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridWang, S=24598284300en_HK
dc.identifier.scopusauthoridChan, Q=6602497305en_HK
dc.identifier.scopusauthoridLaw, W=7103147867en_HK
dc.identifier.scopusauthoridZhang, J=15752209000en_HK
dc.identifier.citeulike7929003-
dc.identifier.issnl1536-1632-

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