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- Publisher Website: 10.1016/j.annepidem.2011.06.002
- Scopus: eid_2-s2.0-80053562297
- PMID: 21784658
- WOS: WOS:000296077100009
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Article: Dose-Response Relation Between Physical Activity and Cognitive Function: Guangzhou Biobank Cohort Study
Title | Dose-Response Relation Between Physical Activity and Cognitive Function: Guangzhou Biobank Cohort Study | ||||||||||
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Authors | |||||||||||
Keywords | Cognitive Function Elderly International Physical Activity Questionnaire Physical Activity | ||||||||||
Issue Date | 2011 | ||||||||||
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/annepidem | ||||||||||
Citation | Annals Of Epidemiology, 2011, v. 21 n. 11, p. 857-863 How to Cite? | ||||||||||
Abstract | Purpose: To examine, via cross-sectional analysis, the dose-response association between physical activity and cognitive function in Chinese subjects. Methods: A total of 27,651 participants aged 50 to 85 years were recruited from 2003 to 2008. Information on potential confounders, including demographic and anthropometric characteristics, socioeconomic position, lifestyle, and disease history, was collected by standardized interview and procedures. Cognitive function was assessed by the delayed 10-word recall test (DWRT). Results: When the International Physical Activity Questionnaire was used, we found that most of the participants were classified as physically active (53.1%), with 42.4% moderately active and 4.5% physically inactive. Significant dose-response relations across quintiles of metabolic equivalent value (METs) with DWRT score in participants with or without good self-rated health were found (all p for trend <.001). In participants with poor self-rated heath, compared with the first quintile of METs, those in the fifth quintile (highest METs) had a significantly reduced risk for mild cognitive impairment by 28% (adjusted odds ratio, 0.72; 95% confidence interval, 0.58-0.89, p < .01; p for trend = .006). After additional adjustment for depression, we found that the association between physical activity and DWRT score remained significant. Conclusions: A significant dose-response relationship between physical activity and cognitive function was found, and the association was more pronounced in participants with poor self-rated health. © 2011 Elsevier Inc. | ||||||||||
Persistent Identifier | http://hdl.handle.net/10722/143819 | ||||||||||
ISSN | 2021 Impact Factor: 6.996 2020 SCImago Journal Rankings: 1.644 | ||||||||||
ISI Accession Number ID |
Funding Information: This work was supported by The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China; and The University of Birmingham, Birmingham, United Kingdom. | ||||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, L | en_HK |
dc.contributor.author | Jiang, CQ | en_HK |
dc.contributor.author | Lam, TH | en_HK |
dc.contributor.author | Zhang, WS | en_HK |
dc.contributor.author | Thomas, GN | en_HK |
dc.contributor.author | Cheng, KK | en_HK |
dc.date.accessioned | 2011-12-21T08:56:40Z | - |
dc.date.available | 2011-12-21T08:56:40Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Annals Of Epidemiology, 2011, v. 21 n. 11, p. 857-863 | en_HK |
dc.identifier.issn | 1047-2797 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/143819 | - |
dc.description.abstract | Purpose: To examine, via cross-sectional analysis, the dose-response association between physical activity and cognitive function in Chinese subjects. Methods: A total of 27,651 participants aged 50 to 85 years were recruited from 2003 to 2008. Information on potential confounders, including demographic and anthropometric characteristics, socioeconomic position, lifestyle, and disease history, was collected by standardized interview and procedures. Cognitive function was assessed by the delayed 10-word recall test (DWRT). Results: When the International Physical Activity Questionnaire was used, we found that most of the participants were classified as physically active (53.1%), with 42.4% moderately active and 4.5% physically inactive. Significant dose-response relations across quintiles of metabolic equivalent value (METs) with DWRT score in participants with or without good self-rated health were found (all p for trend <.001). In participants with poor self-rated heath, compared with the first quintile of METs, those in the fifth quintile (highest METs) had a significantly reduced risk for mild cognitive impairment by 28% (adjusted odds ratio, 0.72; 95% confidence interval, 0.58-0.89, p < .01; p for trend = .006). After additional adjustment for depression, we found that the association between physical activity and DWRT score remained significant. Conclusions: A significant dose-response relationship between physical activity and cognitive function was found, and the association was more pronounced in participants with poor self-rated health. © 2011 Elsevier Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/annepidem | en_HK |
dc.relation.ispartof | Annals of Epidemiology | en_HK |
dc.subject | Cognitive Function | en_HK |
dc.subject | Elderly | en_HK |
dc.subject | International Physical Activity Questionnaire | en_HK |
dc.subject | Physical Activity | en_HK |
dc.subject.mesh | China - epidemiology | - |
dc.subject.mesh | Cognition - physiology | - |
dc.subject.mesh | Cohort Studies | - |
dc.subject.mesh | Mild Cognitive Impairment - epidemiology | - |
dc.subject.mesh | Motor Activity - physiology | - |
dc.title | Dose-Response Relation Between Physical Activity and Cognitive Function: Guangzhou Biobank Cohort Study | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lam, TH:hrmrlth@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lam, TH=rp00326 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.annepidem.2011.06.002 | en_HK |
dc.identifier.pmid | 21784658 | - |
dc.identifier.scopus | eid_2-s2.0-80053562297 | en_HK |
dc.identifier.hkuros | 198044 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80053562297&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 21 | en_HK |
dc.identifier.issue | 11 | en_HK |
dc.identifier.spage | 857 | en_HK |
dc.identifier.epage | 863 | en_HK |
dc.identifier.isi | WOS:000296077100009 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Xu, L=53878780900 | en_HK |
dc.identifier.scopusauthorid | Jiang, CQ=10639500500 | en_HK |
dc.identifier.scopusauthorid | Lam, TH=7202522876 | en_HK |
dc.identifier.scopusauthorid | Zhang, WS=35180743500 | en_HK |
dc.identifier.scopusauthorid | Thomas, GN=35465269900 | en_HK |
dc.identifier.scopusauthorid | Cheng, KK=7402997800 | en_HK |
dc.identifier.citeulike | 9613166 | - |
dc.identifier.issnl | 1047-2797 | - |