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Article: Probing the basic defect in cystic fibrosis

TitleProbing the basic defect in cystic fibrosis
Authors
Tsui, LCOntario
Issue Date1991
PublisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/gde
Citation
Current Opinion In Genetics And Development, 1991, v. 1 n. 1, p. 4-10 How to Cite?
DOI: http://dx.doi.org/10.1016/0959-437X(91)80032-H
AbstractThe concurrent developments in electrophysiology studies and the identification of the cystic fibrosis transmembrane conductance regulator (CFTR) gene has provided a unique opportunity to probe the basic cellular defect underlying cystic fibrosis. Various properties of the CFTR protein have been deduced from its primary sequence, the variety of mutations in patients and genotype-phenotype correlations, as well as the results of more recent DNA transfection studies. The most exciting observation is the fact that CFTR acts like a cAMP-regulated Cl- channel.
Persistent Identifierhttp://hdl.handle.net/10722/143456
ISSN
0959-437X
2023 Impact Factor: 3.7
2023 SCImago Journal Rankings: 2.510
ISI Accession Number ID
WOS:000450881200003

 

DC FieldValueLanguage
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorOntarioen_HK
dc.date.accessioned2011-11-25T09:04:58Z-
dc.date.available2011-11-25T09:04:58Z-
dc.date.issued1991en_HK
dc.identifier.citationCurrent Opinion In Genetics And Development, 1991, v. 1 n. 1, p. 4-10en_HK
dc.identifier.issn0959-437Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/143456-
dc.description.abstractThe concurrent developments in electrophysiology studies and the identification of the cystic fibrosis transmembrane conductance regulator (CFTR) gene has provided a unique opportunity to probe the basic cellular defect underlying cystic fibrosis. Various properties of the CFTR protein have been deduced from its primary sequence, the variety of mutations in patients and genotype-phenotype correlations, as well as the results of more recent DNA transfection studies. The most exciting observation is the fact that CFTR acts like a cAMP-regulated Cl- channel.en_HK
dc.languageeng-
dc.publisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/gdeen_HK
dc.relation.ispartofCurrent Opinion in Genetics and Developmenten_HK
dc.subject.meshCystic Fibrosis - genetics - metabolism - physiopathology-
dc.subject.meshDNA - genetics-
dc.subject.meshLung - physiopathology-
dc.subject.meshMembrane Proteins - deficiency - genetics - physiology-
dc.subject.meshPancreas - physiopathology-
dc.titleProbing the basic defect in cystic fibrosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-437X&volume=1&issue=1&spage=4&epage=10&date=1991&atitle=Probing+the+basic+defect+in+cystic+fibrosis-
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0959-437X(91)80032-H-
dc.identifier.pmid1726721-
dc.identifier.scopuseid_2-s2.0-0026168359en_HK
dc.identifier.volume1en_HK
dc.identifier.issue1en_HK
dc.identifier.spage4en_HK
dc.identifier.epage10en_HK
dc.identifier.isiWOS:000450881200003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridOntario=7409633298en_HK
dc.identifier.issnl0959-437X-

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