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Book Chapter: Cell Therapy for Ventricular Arrhythmias & Ventricular Arrhythmias in Cell Therapy

TitleCell Therapy for Ventricular Arrhythmias & Ventricular Arrhythmias in Cell Therapy
Authors
Issue Date2013
PublisherNova Science Pub Inc.
Citation
Cell Therapy for Ventricular Arrhythmias & Ventricular Arrhythmias in Cell Therapy. In Dudley, SC ... (Eds.)(et al), Ventricular arrhythmia: from principles to patients, p. 107-120. West Hollywood, CA: Nova Science Pub Inc., 2013 How to Cite?
AbstractPathophysiological remodeling of cardiac function occurs at multiple levels, spanning the spectrum from molecular and sub-cellular changes to those occurring at the organ-system levels. Complex alterations in a host of ion channels, Ca2+-cycling proteins, and gap junction related molecules modulates key electrophysiological properties, predisposing to arrhythmias caused by enhanced automaticity, triggered activity, and reentry. Heart failure induced ion channel dysfunction prolongs the AP, increases spatiotemporal gradients of repolarization, promotes the formation of arrhythmogenic triggers and results in conduction abnormalities. Cell-based therapies can significantly improve left ventricular function. As such, these therapies may activate complex signaling processes that reverse remodel the failing heart, and therefore prevent the incidence of arrhythmias. On the other hand, cell based therapies might also alter the resting membrane potential, produce abnormal triggers, promote electrical heterogeneities, modulate conduction, and favor reentrant excitation. Of major concern is the fact that hESC-CMs and, by inference, iPSC-CMs, display a range of functional and structural properties that are remarkably similar to those of failing heart cells. These properties along with a detailed investigation of their electrophysiological consequences require careful investigation before their clinical efficacy can be further assessed.
Persistent Identifierhttp://hdl.handle.net/10722/143054
ISBN

 

DC FieldValueLanguage
dc.contributor.authorAkar, FGen_US
dc.contributor.authorLi, RA-
dc.date.accessioned2011-10-28T03:05:27Z-
dc.date.available2011-10-28T03:05:27Z-
dc.date.issued2013en_US
dc.identifier.citationCell Therapy for Ventricular Arrhythmias & Ventricular Arrhythmias in Cell Therapy. In Dudley, SC ... (Eds.)(et al), Ventricular arrhythmia: from principles to patients, p. 107-120. West Hollywood, CA: Nova Science Pub Inc., 2013-
dc.identifier.isbn9781620815403-
dc.identifier.urihttp://hdl.handle.net/10722/143054-
dc.description.abstractPathophysiological remodeling of cardiac function occurs at multiple levels, spanning the spectrum from molecular and sub-cellular changes to those occurring at the organ-system levels. Complex alterations in a host of ion channels, Ca2+-cycling proteins, and gap junction related molecules modulates key electrophysiological properties, predisposing to arrhythmias caused by enhanced automaticity, triggered activity, and reentry. Heart failure induced ion channel dysfunction prolongs the AP, increases spatiotemporal gradients of repolarization, promotes the formation of arrhythmogenic triggers and results in conduction abnormalities. Cell-based therapies can significantly improve left ventricular function. As such, these therapies may activate complex signaling processes that reverse remodel the failing heart, and therefore prevent the incidence of arrhythmias. On the other hand, cell based therapies might also alter the resting membrane potential, produce abnormal triggers, promote electrical heterogeneities, modulate conduction, and favor reentrant excitation. Of major concern is the fact that hESC-CMs and, by inference, iPSC-CMs, display a range of functional and structural properties that are remarkably similar to those of failing heart cells. These properties along with a detailed investigation of their electrophysiological consequences require careful investigation before their clinical efficacy can be further assessed.-
dc.languageengen_US
dc.publisherNova Science Pub Inc.-
dc.relation.ispartofVentricular arrhythmia: from principles to patients-
dc.titleCell Therapy for Ventricular Arrhythmias & Ventricular Arrhythmias in Cell Therapyen_US
dc.typeBook_Chapteren_US
dc.identifier.emailLi, RA: ronaldli@hkucc.hku.hken_US
dc.identifier.authorityLi, RA=rp01352en_US
dc.identifier.hkuros197132en_US
dc.identifier.spage107-
dc.identifier.epage120-
dc.publisher.placeWest Hollywood, CA-
dc.customcontrol.immutableyiu 131216-

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