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- Publisher Website: 10.1016/j.annepidem.2010.06.005
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- PMID: 20705480
- WOS: WOS:000284669000001
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Article: Moderate alcohol use and cognitive function in the guangzhou biobank cohort study
Title | Moderate alcohol use and cognitive function in the guangzhou biobank cohort study | ||||||||||||
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Authors | |||||||||||||
Keywords | Alcohol Chinese Cognition | ||||||||||||
Issue Date | 2010 | ||||||||||||
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/annepidem | ||||||||||||
Citation | Annals Of Epidemiology, 2010, v. 20 n. 12, p. 873-882 How to Cite? | ||||||||||||
Abstract | Purpose: Observational studies in Western settings show moderate alcohol use associated with better cognitive function, but they are vulnerable to contextual bias. Evidence from non-Western settings may be useful to verify causality. We examined such association in southern China where alcohol use is low. Methods: We used multivariable linear regression in cross-sectional data from the Guangzhou Biobank Cohort Study to assess sex-stratified associations of alcohol use (never, occasional, moderate, heavy and former drinker) with delayed 10-word recall score for all 3 phases (N = 28,537) and Mini-Mental State Examination (MMSE) score in phase 3 (N = 9,571). Results: Delayed 10-word recall scores were higher in moderate drinkers compared with never drinkers among men (0.30 words, 95% confidence interval [CI]: 0.18 to 0.42) but not women (0.02; 95% CI: -0.12 to 0.17), adjusted for sociodemographic factors. Occasional alcohol users also had higher 10-word recall scores among men (0.27; 95% CI: 0.18 to 0.37) and women (0.30; 95% CI: 0.23 to 0.37). These estimates were little altered by further adjustment for cardiovascular risk factors. Results for MMSE scores were similar. Conclusions: Alcohol may not drive the association between moderate use and better cognitive function, which instead may be due to confounding by general moderation in lifestyle. © 2010 Elsevier Inc. | ||||||||||||
Persistent Identifier | http://hdl.handle.net/10722/142579 | ||||||||||||
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.382 | ||||||||||||
ISI Accession Number ID |
Funding Information: The study was funded by The University of Hong Kong Foundation for Development and Research, and the University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Bureau, Guangzhou, China; and The University of Birmingham, UK. The funding sources had no role in any of the following: study design; the collection, analysis, and interpretation of data; the writing of the report; and the decision to submit the paper for publication. | ||||||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Au Yeung, SL | en_HK |
dc.contributor.author | Jiang, C | en_HK |
dc.contributor.author | Zhang, W | en_HK |
dc.contributor.author | Lam, TH | en_HK |
dc.contributor.author | Cheng, KK | en_HK |
dc.contributor.author | Leung, GM | en_HK |
dc.contributor.author | Schooling, CM | en_HK |
dc.date.accessioned | 2011-10-28T02:51:48Z | - |
dc.date.available | 2011-10-28T02:51:48Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Annals Of Epidemiology, 2010, v. 20 n. 12, p. 873-882 | en_HK |
dc.identifier.issn | 1047-2797 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/142579 | - |
dc.description.abstract | Purpose: Observational studies in Western settings show moderate alcohol use associated with better cognitive function, but they are vulnerable to contextual bias. Evidence from non-Western settings may be useful to verify causality. We examined such association in southern China where alcohol use is low. Methods: We used multivariable linear regression in cross-sectional data from the Guangzhou Biobank Cohort Study to assess sex-stratified associations of alcohol use (never, occasional, moderate, heavy and former drinker) with delayed 10-word recall score for all 3 phases (N = 28,537) and Mini-Mental State Examination (MMSE) score in phase 3 (N = 9,571). Results: Delayed 10-word recall scores were higher in moderate drinkers compared with never drinkers among men (0.30 words, 95% confidence interval [CI]: 0.18 to 0.42) but not women (0.02; 95% CI: -0.12 to 0.17), adjusted for sociodemographic factors. Occasional alcohol users also had higher 10-word recall scores among men (0.27; 95% CI: 0.18 to 0.37) and women (0.30; 95% CI: 0.23 to 0.37). These estimates were little altered by further adjustment for cardiovascular risk factors. Results for MMSE scores were similar. Conclusions: Alcohol may not drive the association between moderate use and better cognitive function, which instead may be due to confounding by general moderation in lifestyle. © 2010 Elsevier Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/annepidem | en_HK |
dc.relation.ispartof | Annals of Epidemiology | en_HK |
dc.subject | Alcohol | en_HK |
dc.subject | Chinese | en_HK |
dc.subject | Cognition | en_HK |
dc.subject.mesh | Alcohol Drinking - epidemiology - psychology | - |
dc.subject.mesh | China - epidemiology | - |
dc.subject.mesh | Cognition | - |
dc.subject.mesh | Cohort Studies | - |
dc.subject.mesh | Mental Recall | - |
dc.title | Moderate alcohol use and cognitive function in the guangzhou biobank cohort study | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lam, TH:hrmrlth@hkucc.hku.hk | en_HK |
dc.identifier.email | Leung, GM:gmleung@hku.hk | en_HK |
dc.identifier.email | Schooling, CM:cms1@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lam, TH=rp00326 | en_HK |
dc.identifier.authority | Leung, GM=rp00460 | en_HK |
dc.identifier.authority | Schooling, CM=rp00504 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.annepidem.2010.06.005 | en_HK |
dc.identifier.pmid | 20705480 | - |
dc.identifier.scopus | eid_2-s2.0-78149469034 | en_HK |
dc.identifier.hkuros | 184547 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-78149469034&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 20 | en_HK |
dc.identifier.issue | 12 | en_HK |
dc.identifier.spage | 873 | en_HK |
dc.identifier.epage | 882 | en_HK |
dc.identifier.isi | WOS:000284669000001 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Au Yeung, SL=8871840600 | en_HK |
dc.identifier.scopusauthorid | Jiang, C=10639500500 | en_HK |
dc.identifier.scopusauthorid | Zhang, W=13410704100 | en_HK |
dc.identifier.scopusauthorid | Lam, TH=7202522876 | en_HK |
dc.identifier.scopusauthorid | Cheng, KK=7402997800 | en_HK |
dc.identifier.scopusauthorid | Leung, GM=7007159841 | en_HK |
dc.identifier.scopusauthorid | Schooling, CM=12808565000 | en_HK |
dc.identifier.citeulike | 7817716 | - |
dc.identifier.issnl | 1047-2797 | - |