File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1097/SLA.0b013e3182300a1d
- Scopus: eid_2-s2.0-80053284820
- PMID: 21892074
- WOS: WOS:000295162400004
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Prediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: A prospective study
Title | Prediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: A prospective study | ||||
---|---|---|---|---|---|
Authors | |||||
Issue Date | 2011 | ||||
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com | ||||
Citation | Annals Of Surgery, 2011, v. 254 n. 4, p. 569-576 How to Cite? | ||||
Abstract | OBJECTIVE: To investigate whether circulating cancer stem cells (CSCs) of hepatocellular carcinoma (HCC) can predict its recurrence after hepatectomy. BACKGROUND: HCC recurrence frequently occurs within the first year after hepatectomy, probably due to circulating tumor cells that have been shed from the primary tumor before hepatectomy. Because CSCs are more likely to initiate tumor growth than mature cancer cells, a high level of circulating CSCs may be a hint for HCC recurrence. METHODS: Multicolor flow cytometry was used to detect the number of circulating CSCs (CD45 -CD90 +CD44 +) in the peripheral circulation of 82 HCC patients 1 day before hepatectomy. The patients were monitored by CT or MRI for recurrence every 3 months. RESULTS: Forty-one (50%) patients had recurrence after a median follow-up period of 13.2 months (range, 1.3-57.1 months). Patients with recurrence had a higher median level of circulating CSCs than patients without recurrence (0.02% vs. 0.01%; P < 0.0001). Circulating CSCs > 0.01% predicted intrahepatic recurrence (relative risk 3.54; 95% CI, 1.41-8.88; P = 0.007) and extrahepatic recurrence (relative risk 10.15; 95% CI, 3-34.4; P = 0.0002). Patients with >0.01% circulating CSCs had a lower 2-year recurrence-free survival rate (22.7% vs. 64.2%; P < 0.0001) and overall survival rate (58.5% vs. 94.1%; P = 0.0005) than patients with ≤0.01% circulating CSCs. On multivariable analysis, circulating CSCs > 0.01%, tumor stage and tumor size were independent factors predicting recurrence-free survival. CONCLUSIONS: Circulating CSCs predicted posthepatectomy HCC recurrence with high accuracy. They may be the target of eradication in the prevention of posthepatectomy HCC metastasis and recurrence. Copyright © 2011 by Lippincott Williams & Wilkins. | ||||
Description | Papers of the 131st ASA annual meeting | ||||
Persistent Identifier | http://hdl.handle.net/10722/142543 | ||||
ISSN | 2021 Impact Factor: 13.787 2020 SCImago Journal Rankings: 4.153 | ||||
ISI Accession Number ID |
Funding Information: Supported by Mrs. Li Ka Shing Fund, The University of Hong Kong, Hong Kong, China. | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fan, ST | en_HK |
dc.contributor.author | Yang, ZF | en_HK |
dc.contributor.author | Ho, DWY | en_HK |
dc.contributor.author | Ng, MNP | en_HK |
dc.contributor.author | Yu, WC | en_HK |
dc.contributor.author | Wong, J | en_HK |
dc.date.accessioned | 2011-10-28T02:50:56Z | - |
dc.date.available | 2011-10-28T02:50:56Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Annals Of Surgery, 2011, v. 254 n. 4, p. 569-576 | en_HK |
dc.identifier.issn | 0003-4932 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/142543 | - |
dc.description | Papers of the 131st ASA annual meeting | - |
dc.description.abstract | OBJECTIVE: To investigate whether circulating cancer stem cells (CSCs) of hepatocellular carcinoma (HCC) can predict its recurrence after hepatectomy. BACKGROUND: HCC recurrence frequently occurs within the first year after hepatectomy, probably due to circulating tumor cells that have been shed from the primary tumor before hepatectomy. Because CSCs are more likely to initiate tumor growth than mature cancer cells, a high level of circulating CSCs may be a hint for HCC recurrence. METHODS: Multicolor flow cytometry was used to detect the number of circulating CSCs (CD45 -CD90 +CD44 +) in the peripheral circulation of 82 HCC patients 1 day before hepatectomy. The patients were monitored by CT or MRI for recurrence every 3 months. RESULTS: Forty-one (50%) patients had recurrence after a median follow-up period of 13.2 months (range, 1.3-57.1 months). Patients with recurrence had a higher median level of circulating CSCs than patients without recurrence (0.02% vs. 0.01%; P < 0.0001). Circulating CSCs > 0.01% predicted intrahepatic recurrence (relative risk 3.54; 95% CI, 1.41-8.88; P = 0.007) and extrahepatic recurrence (relative risk 10.15; 95% CI, 3-34.4; P = 0.0002). Patients with >0.01% circulating CSCs had a lower 2-year recurrence-free survival rate (22.7% vs. 64.2%; P < 0.0001) and overall survival rate (58.5% vs. 94.1%; P = 0.0005) than patients with ≤0.01% circulating CSCs. On multivariable analysis, circulating CSCs > 0.01%, tumor stage and tumor size were independent factors predicting recurrence-free survival. CONCLUSIONS: Circulating CSCs predicted posthepatectomy HCC recurrence with high accuracy. They may be the target of eradication in the prevention of posthepatectomy HCC metastasis and recurrence. Copyright © 2011 by Lippincott Williams & Wilkins. | en_HK |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com | en_HK |
dc.relation.ispartof | Annals of Surgery | en_HK |
dc.subject.mesh | Carcinoma, Hepatocellular - blood - surgery | - |
dc.subject.mesh | Hepatectomy | - |
dc.subject.mesh | Liver Neoplasms - blood - surgery | - |
dc.subject.mesh | Neoplasm Recurrence, Local - blood - epidemiology | - |
dc.subject.mesh | Neoplastic Stem Cells | - |
dc.title | Prediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: A prospective study | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-4932&volume=254&issue=4&spage=569&epage=576&date=2011&atitle=Prediction+of+posthepatectomy+recurrence+of+hepatocellular+carcinoma+by+circulating+cancer+stem+cells:+a+prospective+study | en_US |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_HK |
dc.identifier.email | Wong, J: jwong@hkucc.hku.hk | en_HK |
dc.identifier.authority | Fan, ST=rp00355 | en_HK |
dc.identifier.authority | Wong, J=rp00322 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1097/SLA.0b013e3182300a1d | en_HK |
dc.identifier.pmid | 21892074 | - |
dc.identifier.scopus | eid_2-s2.0-80053284820 | en_HK |
dc.identifier.hkuros | 196688 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80053284820&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 254 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 569 | en_HK |
dc.identifier.epage | 576 | en_HK |
dc.identifier.isi | WOS:000295162400004 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.f1000 | 14257962 | - |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_HK |
dc.identifier.scopusauthorid | Yang, ZF=39863860200 | en_HK |
dc.identifier.scopusauthorid | Ho, DWY=7402971906 | en_HK |
dc.identifier.scopusauthorid | Ng, MNP=23478329500 | en_HK |
dc.identifier.scopusauthorid | Yu, WC=37022285400 | en_HK |
dc.identifier.scopusauthorid | Wong, J=8049324500 | en_HK |
dc.identifier.issnl | 0003-4932 | - |