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- Publisher Website: 10.1002/jor.21124
- Scopus: eid_2-s2.0-78650964953
- PMID: 20196083
- WOS: WOS:000286285900003
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Article: Effect of psoralen on bone formation
Title | Effect of psoralen on bone formation | ||||
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Authors | |||||
Keywords | bone graft collagen psoralen | ||||
Issue Date | 2011 | ||||
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres | ||||
Citation | Journal Of Orthopaedic Research, 2011, v. 29 n. 2, p. 158-164 How to Cite? | ||||
Abstract | To compare the amount of new bone and bone cells produced by psoralen in collagen matrix to that produced by collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 were created in the parietal bone of nine New Zealand White rabbits. Six defects were grafted with psoralen mixed with collagen matrix. Six defects were grafted with collagen matrix alone (negative control-collagen) and six were left empty (negative controla-empty). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells were made on 100 sections (50 sections for each group) using image analysis. A total of 454% more new bone was present in defects grafted with psoralen in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control-empty group. The amount of bone forming osteoblasts was also significantly greater in the psoralen group than the negative control-collagen group. Psoralen in collagen matrix has the effect of increasing new bone formation locally in vivo. Psoralen in collagen matrix can be developed as a bone graft material. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. | ||||
Persistent Identifier | http://hdl.handle.net/10722/142273 | ||||
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.886 | ||||
ISI Accession Number ID |
Funding Information: This study was funded by University Research Grant (10208640/36170/08000/310/01), the University of Hong Kong. Editorial assistance performed by Dr. Trevor Lane. | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wong, RWK | en_HK |
dc.contributor.author | Rabie, ABM | en_HK |
dc.date.accessioned | 2011-10-28T02:41:59Z | - |
dc.date.available | 2011-10-28T02:41:59Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Journal Of Orthopaedic Research, 2011, v. 29 n. 2, p. 158-164 | en_HK |
dc.identifier.issn | 0736-0266 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/142273 | - |
dc.description.abstract | To compare the amount of new bone and bone cells produced by psoralen in collagen matrix to that produced by collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 were created in the parietal bone of nine New Zealand White rabbits. Six defects were grafted with psoralen mixed with collagen matrix. Six defects were grafted with collagen matrix alone (negative control-collagen) and six were left empty (negative controla-empty). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells were made on 100 sections (50 sections for each group) using image analysis. A total of 454% more new bone was present in defects grafted with psoralen in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control-empty group. The amount of bone forming osteoblasts was also significantly greater in the psoralen group than the negative control-collagen group. Psoralen in collagen matrix has the effect of increasing new bone formation locally in vivo. Psoralen in collagen matrix can be developed as a bone graft material. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres | en_HK |
dc.relation.ispartof | Journal of Orthopaedic Research | en_HK |
dc.rights | Journal of Orthopaedic Research. Copyright © John Wiley & Sons, Inc. | - |
dc.subject | bone graft | en_HK |
dc.subject | collagen | en_HK |
dc.subject | psoralen | en_HK |
dc.subject.mesh | Bone Regeneration - drug effects | - |
dc.subject.mesh | Cross-Linking Reagents - pharmacology | - |
dc.subject.mesh | Ficusin - pharmacology | - |
dc.subject.mesh | Osteogenesis - drug effects | - |
dc.subject.mesh | Collagen | - |
dc.title | Effect of psoralen on bone formation | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Rabie, ABM: rabie@hku.hk | en_HK |
dc.identifier.authority | Rabie, ABM=rp00029 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/jor.21124 | en_HK |
dc.identifier.pmid | 20196083 | - |
dc.identifier.scopus | eid_2-s2.0-78650964953 | en_HK |
dc.identifier.hkuros | 184368 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-78650964953&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 29 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 158 | en_HK |
dc.identifier.epage | 164 | en_HK |
dc.identifier.isi | WOS:000286285900003 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Wong, RWK=36642905800 | en_HK |
dc.identifier.scopusauthorid | Rabie, ABM=7007172734 | en_HK |
dc.identifier.issnl | 0736-0266 | - |