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Article: Optical coherence tomography analysis of bilateral end-stage choroidal neovascularization where one eye is treated with photodynamic therapy

TitleOptical coherence tomography analysis of bilateral end-stage choroidal neovascularization where one eye is treated with photodynamic therapy
Authors
KeywordsAge-related macular degeneration
Choroidal neovascularization
Optical coherence tomography
Photodynamic therapy
Issue Date2007
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEO
Citation
Clinical And Experimental Ophthalmology, 2007, v. 35 n. 1, p. 13-17 How to Cite?
AbstractBackground: To compare retinal thickness and subretinal hyper-reflectivity using Stratus optical coherence tomography (OCT3) between the eyes of patients with bilateral end-stage exudative age-related macular degeneration (AMD), where one eye has been treated with photodynamic therapy (PDT). Methods: Patients with PDT-treated stable choroidal neovascularization (CNV), defined as a fibrotic lesion not requiring treatment for 6 months, in one eye and an untreated end-stage CNV (disciform) scar in their fellow eye, underwent refraction protocol logMAR visual acuity (VA) in letters, slit-lamp biomicroscopy, fluorescein angiography and OCT3 scan. Subretinal scar thickness was measured as Outer High Reflectivity Band Thickness (OHRBT) and retinal thickness as neuroretinal foveal thickness (NFT) on OCT3. Results: Thirty-two eyes of 16 patients were studied. Mean OHRBT was 255.62 μm in treated eyes and 350.8 μm in untreated eyes (P = 0.001). Mean NFT was 130.3 μm in the treated eye and 79.9 μm in the untreated eye (P = 0.017). Mean VA was 42 letters in treated eyes and 15 letters in untreated eyes (P < 0.005). Conclusion: Based on OCT3 findings, eyes with AMD treated with PDT have a thinner fibrous scar and better preserved retinal thickness when compared with untreated fellow eyes with end-stage fibrotic scarring. © 2006 The Authors; Journal compilation © 2006 Royal Australian and New Zealand College of Ophthalmologists.
Persistent Identifierhttp://hdl.handle.net/10722/138164
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.368
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSahni, Jen_HK
dc.contributor.authorStanga, Pen_HK
dc.contributor.authorWong, Den_HK
dc.contributor.authorLenfestey, Pen_HK
dc.contributor.authorKent, Den_HK
dc.contributor.authorHarding, Sen_HK
dc.date.accessioned2011-08-26T14:42:12Z-
dc.date.available2011-08-26T14:42:12Z-
dc.date.issued2007en_HK
dc.identifier.citationClinical And Experimental Ophthalmology, 2007, v. 35 n. 1, p. 13-17en_HK
dc.identifier.issn1442-6404en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138164-
dc.description.abstractBackground: To compare retinal thickness and subretinal hyper-reflectivity using Stratus optical coherence tomography (OCT3) between the eyes of patients with bilateral end-stage exudative age-related macular degeneration (AMD), where one eye has been treated with photodynamic therapy (PDT). Methods: Patients with PDT-treated stable choroidal neovascularization (CNV), defined as a fibrotic lesion not requiring treatment for 6 months, in one eye and an untreated end-stage CNV (disciform) scar in their fellow eye, underwent refraction protocol logMAR visual acuity (VA) in letters, slit-lamp biomicroscopy, fluorescein angiography and OCT3 scan. Subretinal scar thickness was measured as Outer High Reflectivity Band Thickness (OHRBT) and retinal thickness as neuroretinal foveal thickness (NFT) on OCT3. Results: Thirty-two eyes of 16 patients were studied. Mean OHRBT was 255.62 μm in treated eyes and 350.8 μm in untreated eyes (P = 0.001). Mean NFT was 130.3 μm in the treated eye and 79.9 μm in the untreated eye (P = 0.017). Mean VA was 42 letters in treated eyes and 15 letters in untreated eyes (P < 0.005). Conclusion: Based on OCT3 findings, eyes with AMD treated with PDT have a thinner fibrous scar and better preserved retinal thickness when compared with untreated fellow eyes with end-stage fibrotic scarring. © 2006 The Authors; Journal compilation © 2006 Royal Australian and New Zealand College of Ophthalmologists.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEOen_HK
dc.relation.ispartofClinical and Experimental Ophthalmologyen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectAge-related macular degenerationen_HK
dc.subjectChoroidal neovascularizationen_HK
dc.subjectOptical coherence tomographyen_HK
dc.subjectPhotodynamic therapyen_HK
dc.subject.meshChoroidal Neovascularization - diagnosis - drug therapy-
dc.subject.meshMacular Degeneration - diagnosis - drug therapy-
dc.subject.meshPhotochemotherapy-
dc.subject.meshRetina - pathology-
dc.subject.meshTomography, Optical Coherence-
dc.titleOptical coherence tomography analysis of bilateral end-stage choroidal neovascularization where one eye is treated with photodynamic therapyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1442-6404&volume=35&issue=1&spage=13&epage=17&date=2007&atitle=Optical+coherence+tomography+analysis+of+bilateral+end-stage+choroidal+neovascularization+where+one+eye+is+treated+with+photodynamic+therapy-
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1442-9071.2006.01385.xen_HK
dc.identifier.pmid17300565-
dc.identifier.scopuseid_2-s2.0-33846671208en_HK
dc.identifier.hkuros191484en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846671208&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue1en_HK
dc.identifier.spage13en_HK
dc.identifier.epage17en_HK
dc.identifier.isiWOS:000243866900004-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridSahni, J=6701353395en_HK
dc.identifier.scopusauthoridStanga, P=6602197864en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK
dc.identifier.scopusauthoridLenfestey, P=15837025000en_HK
dc.identifier.scopusauthoridKent, D=35512364500en_HK
dc.identifier.scopusauthoridHarding, S=7202447700en_HK
dc.identifier.citeulike1081429-
dc.identifier.issnl1442-6404-

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