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Article: Meta-analysis of randomized controlled trials to assess the effectiveness and safety of free and easy Wanderer plus, a polyherbal preparation for depressive disorders

TitleMeta-analysis of randomized controlled trials to assess the effectiveness and safety of free and easy Wanderer plus, a polyherbal preparation for depressive disorders
Authors
Qin, FWu, XATang, YHuang, QZhang, ZJYuan, JH
KeywordsDepression disorders
Free and easy Wanderer plus
Meta-analysis
Polyherbal preparation
Issue Date2011
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychires
Citation
Journal Of Psychiatric Research, 2011, v. 45 n. 11, p. 1518-1524 How to Cite?
DOI: http://dx.doi.org/10.1016/j.jpsychires.2011.06.018
AbstractFree and Easy Wanderer Plus (FEWP) is a polyherbal preparation which therapeutic benefits have been extensively evaluated in patients with various depressive disorders. The purpose of this meta-analysis was to assess the overall effectiveness and safety of FEWP. Following systematic review, a total of 14 high-quality randomized controlled trials (RCTs) were identified and included in the meta-analysis. Statistically greater treatment effects were found in FEWP monotherapy compared to placebo and in FEWP combined with conventional anti-depressants (CADs) compared to CADs alone. Patients taking FEWP alone and combined with CADs experienced fewer adverse events of dizziness, headache, dry mouth, nausea, and constipation compared to CADs alone. These data suggest that FEWP may be an effective herbal agent in treating depressive symptoms. The addition of FEWP also enhances antidepressant effects of CADs. FEWP may have a higher safety profile compared to CADs. © 2011.
Persistent Identifierhttp://hdl.handle.net/10722/137511
ISSN
0022-3956
2021 Impact Factor: 5.250
2020 SCImago Journal Rankings: 1.875
ISI Accession Number ID
WOS:000296688100016
Funding AgencyGrant Number
National Natural Science Foundation of China30872570
Funding Information:

This project was supported by the National Natural Science Foundation of China (No. 30872570).

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorQin, Fen_HK
dc.contributor.authorWu, XAen_HK
dc.contributor.authorTang, Yen_HK
dc.contributor.authorHuang, Qen_HK
dc.contributor.authorZhang, ZJen_HK
dc.contributor.authorYuan, JHen_HK
dc.date.accessioned2011-08-26T14:26:51Z-
dc.date.available2011-08-26T14:26:51Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Psychiatric Research, 2011, v. 45 n. 11, p. 1518-1524en_HK
dc.identifier.issn0022-3956en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137511-
dc.description.abstractFree and Easy Wanderer Plus (FEWP) is a polyherbal preparation which therapeutic benefits have been extensively evaluated in patients with various depressive disorders. The purpose of this meta-analysis was to assess the overall effectiveness and safety of FEWP. Following systematic review, a total of 14 high-quality randomized controlled trials (RCTs) were identified and included in the meta-analysis. Statistically greater treatment effects were found in FEWP monotherapy compared to placebo and in FEWP combined with conventional anti-depressants (CADs) compared to CADs alone. Patients taking FEWP alone and combined with CADs experienced fewer adverse events of dizziness, headache, dry mouth, nausea, and constipation compared to CADs alone. These data suggest that FEWP may be an effective herbal agent in treating depressive symptoms. The addition of FEWP also enhances antidepressant effects of CADs. FEWP may have a higher safety profile compared to CADs. © 2011.en_HK
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychiresen_HK
dc.relation.ispartofJournal of Psychiatric Researchen_HK
dc.subjectDepression disordersen_HK
dc.subjectFree and easy Wanderer plusen_HK
dc.subjectMeta-analysisen_HK
dc.subjectPolyherbal preparationen_HK
dc.subject.meshAntidepressive Agents - administration and dosage - adverse effects-
dc.subject.meshConstipation - chemically induced-
dc.subject.meshDepressive Disorder - drug therapy-
dc.subject.meshDizziness - chemically induced-
dc.subject.meshDrugs, Chinese Herbal - administration and dosage - adverse effects-
dc.titleMeta-analysis of randomized controlled trials to assess the effectiveness and safety of free and easy Wanderer plus, a polyherbal preparation for depressive disordersen_HK
dc.typeArticleen_HK
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_HK
dc.identifier.authorityZhang, ZJ=rp01297en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jpsychires.2011.06.018en_HK
dc.identifier.pmid21820672-
dc.identifier.scopuseid_2-s2.0-80053944889en_HK
dc.identifier.hkuros189650en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053944889&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume45en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1518en_HK
dc.identifier.epage1524en_HK
dc.identifier.isiWOS:000296688100016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridQin, F=7006550175en_HK
dc.identifier.scopusauthoridWu, XA=54404055000en_HK
dc.identifier.scopusauthoridTang, Y=35308392100en_HK
dc.identifier.scopusauthoridHuang, Q=36050366700en_HK
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_HK
dc.identifier.scopusauthoridYuan, JH=54404261500en_HK
dc.identifier.citeulike9664935-
dc.identifier.issnl0022-3956-

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