File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: Possible association with inflammatory cells

TitleReceptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: Possible association with inflammatory cells
Authors
KeywordsApical periodontitis
Bone resorption
Immunohistochemistry
Inflammation
Osteoprotegerin
Receptor activator of nuclear factor kappa B ligand
Issue Date2011
PublisherZhonghua Yixuehui. The Journal's web site is located at http://med.wanfangdata.com.cn/Paper/PeriodicalInfo.aspx?periodicalID=zhcmj
Citation
Chinese Medical Journal, 2011, v. 124 n. 14, p. 2162-2166 How to Cite?
AbstractBackground Receptor activator of nuclear factor kappa B (NF-kB) ligand (RANKL) and osteoprotegerin (OPG) have been recently shown to play important roles in bone resorption. The aim of this study was to investigate the possible association between the expression of bone resorption regulators (RANKL and OPG) and inflammatory cell infiltration in chronic apical periodontitis. Methods The samples of chronic periapical lesions (n=40) and healthy periapical tissues (n=10) were examined for immunohistochemical analysis of RANKL and OPG. Lesion samples were further analyzed for the inflammatory infiltration condition. The inflammatory cell infiltration was scored in relation to immunohistochemical reactivity for CD3, CD20 and CD68. Results The number of RANKL-positive cells and the ratio of RANKL/OPG in chronic apical periodontitis were significantly higher than those in healthy periapical tissues (P <0.001). The number of RANKL-positive cells was higher in lesions with severe inflammatory infiltration than in those with light inflammatory infiltration (P <0.05). Significantly increased RANKL expression was found with T lymphocytes (CD3 +), macrophages (CD68 +) and B lymphocytes (CD20 +) infiltration (P <0.05). No association was found between the ratio of RANKL/OPG and inflammatory cell infiltration. Conclusions RANKL expression was increased with T, B lymphocytes and macrophages infiltration, respectively in chronic periapical lesions. RANKL appears to be closely related to periapical inflammatory infiltrates. The relative ratio of RANKL/OPG may be a key determinant of RANKL-mediated bone resorption.
Persistent Identifierhttp://hdl.handle.net/10722/137178
ISSN
2023 Impact Factor: 7.5
2023 SCImago Journal Rankings: 0.997
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFan, Ren_HK
dc.contributor.authorSun, Ben_HK
dc.contributor.authorZhang, CFen_HK
dc.contributor.authorLü, YLen_HK
dc.contributor.authorXuan, Wen_HK
dc.contributor.authorWang, QQen_HK
dc.contributor.authorYin, XZen_HK
dc.date.accessioned2011-08-26T14:18:03Z-
dc.date.available2011-08-26T14:18:03Z-
dc.date.issued2011en_HK
dc.identifier.citationChinese Medical Journal, 2011, v. 124 n. 14, p. 2162-2166en_HK
dc.identifier.issn0366-6999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137178-
dc.description.abstractBackground Receptor activator of nuclear factor kappa B (NF-kB) ligand (RANKL) and osteoprotegerin (OPG) have been recently shown to play important roles in bone resorption. The aim of this study was to investigate the possible association between the expression of bone resorption regulators (RANKL and OPG) and inflammatory cell infiltration in chronic apical periodontitis. Methods The samples of chronic periapical lesions (n=40) and healthy periapical tissues (n=10) were examined for immunohistochemical analysis of RANKL and OPG. Lesion samples were further analyzed for the inflammatory infiltration condition. The inflammatory cell infiltration was scored in relation to immunohistochemical reactivity for CD3, CD20 and CD68. Results The number of RANKL-positive cells and the ratio of RANKL/OPG in chronic apical periodontitis were significantly higher than those in healthy periapical tissues (P <0.001). The number of RANKL-positive cells was higher in lesions with severe inflammatory infiltration than in those with light inflammatory infiltration (P <0.05). Significantly increased RANKL expression was found with T lymphocytes (CD3 +), macrophages (CD68 +) and B lymphocytes (CD20 +) infiltration (P <0.05). No association was found between the ratio of RANKL/OPG and inflammatory cell infiltration. Conclusions RANKL expression was increased with T, B lymphocytes and macrophages infiltration, respectively in chronic periapical lesions. RANKL appears to be closely related to periapical inflammatory infiltrates. The relative ratio of RANKL/OPG may be a key determinant of RANKL-mediated bone resorption.en_HK
dc.languageengen_US
dc.publisherZhonghua Yixuehui. The Journal's web site is located at http://med.wanfangdata.com.cn/Paper/PeriodicalInfo.aspx?periodicalID=zhcmjen_HK
dc.relation.ispartofChinese Medical Journalen_HK
dc.subjectApical periodontitis-
dc.subjectBone resorption-
dc.subjectImmunohistochemistry-
dc.subjectInflammation-
dc.subjectOsteoprotegerin-
dc.subjectReceptor activator of nuclear factor kappa B ligand-
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshChronic Periodontitis - immunology - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshInflammation - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOsteoprotegerin - metabolismen_HK
dc.subject.meshRANK Ligand - metabolismen_HK
dc.subject.meshYoung Adulten_HK
dc.titleReceptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: Possible association with inflammatory cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailZhang, CF:zhangcf@hku.hken_HK
dc.identifier.authorityZhang, CF=rp01408en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3760/cma.j.issn.0366-6999.2011.14.015en_HK
dc.identifier.pmid21933620-
dc.identifier.scopuseid_2-s2.0-79960684152en_HK
dc.identifier.hkuros190359en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960684152&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume124en_HK
dc.identifier.issue14en_HK
dc.identifier.spage2162en_HK
dc.identifier.epage2166en_HK
dc.identifier.isiWOS:000293491100015-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridFan, R=7102030189en_HK
dc.identifier.scopusauthoridSun, B=55079287400en_HK
dc.identifier.scopusauthoridZhang, CF=7405494609en_HK
dc.identifier.scopusauthoridLü, YL=35788913400en_HK
dc.identifier.scopusauthoridXuan, W=36129182300en_HK
dc.identifier.scopusauthoridWang, QQ=46961364300en_HK
dc.identifier.scopusauthoridYin, XZ=15830792400en_HK
dc.identifier.issnl0366-6999-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats