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Conference Paper: Lectin from Agaricus bisporus suppresses Akt phosphorylation and arrests cell cycle progression in primary human retinal pigment epithelial cells

TitleLectin from Agaricus bisporus suppresses Akt phosphorylation and arrests cell cycle progression in primary human retinal pigment epithelial cells
Authors
Cheung, YHLo, ACYWong, DLai, WWK
Keywords698 retinal pigment epithelium
651 proliferation
652 proliferative vitreoretinopathy
Issue Date2011
PublisherAssociation for Research in Vision and Ophthalmology, Inc..
Citation
The 2011 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Font Lauderdale, FL., 1-5 May 2011. How to Cite?
AbstractPURPOSE: Lectin from the edible mushroom Agaricus bisporus (ABL) was found to inhibit growth of certain cancer cell lines as well as proliferation of retinal pigment epithelial (RPE) cell lines in a potent manner. The mechanism for the observed inhibition is unclear. To elucidate the mechanism through which ABL inhibits RPE cell proliferation, we investigated the changes in cell proliferation-related signaling pathways and cell cycle distribution patterns. METHODS: Primary human RPE cells (passages 6 to 10) were utilized. Cells were grown in DMEM/F12 …
DescriptionSession 511. Retinal Degenerative Diseases: no. 5339/A4
Persistent Identifierhttp://hdl.handle.net/10722/136446

 

DC FieldValueLanguage
dc.contributor.authorCheung, YHen_US
dc.contributor.authorLo, ACYen_US
dc.contributor.authorWong, Den_US
dc.contributor.authorLai, WWKen_US
dc.date.accessioned2011-07-27T02:16:16Z-
dc.date.available2011-07-27T02:16:16Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Font Lauderdale, FL., 1-5 May 2011.en_US
dc.identifier.urihttp://hdl.handle.net/10722/136446-
dc.descriptionSession 511. Retinal Degenerative Diseases: no. 5339/A4-
dc.description.abstractPURPOSE: Lectin from the edible mushroom Agaricus bisporus (ABL) was found to inhibit growth of certain cancer cell lines as well as proliferation of retinal pigment epithelial (RPE) cell lines in a potent manner. The mechanism for the observed inhibition is unclear. To elucidate the mechanism through which ABL inhibits RPE cell proliferation, we investigated the changes in cell proliferation-related signaling pathways and cell cycle distribution patterns. METHODS: Primary human RPE cells (passages 6 to 10) were utilized. Cells were grown in DMEM/F12 …-
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology, Inc..-
dc.relation.ispartofAnnual Meeting of the Association for Research in Vision and Ophthalmology, ARVO 2011en_US
dc.subject698 retinal pigment epithelium-
dc.subject651 proliferation-
dc.subject652 proliferative vitreoretinopathy-
dc.titleLectin from Agaricus bisporus suppresses Akt phosphorylation and arrests cell cycle progression in primary human retinal pigment epithelial cellsen_US
dc.typeConference_Paperen_US
dc.identifier.emailLo, ACY: amylo@hkucc.hku.hken_US
dc.identifier.emailWong, D: shdwong@hku.hken_US
dc.identifier.emailLai, WWK: wicolai@hku.hken_US
dc.identifier.authorityLo, ACY=rp00425en_US
dc.identifier.authorityWong, D=rp00516en_US
dc.identifier.authorityLai, WWK=rp00531en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros186644en_US

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