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Conference Paper: The role of proheparanase in synaptic plasticity at the hippocampus
| Title | The role of proheparanase in synaptic plasticity at the hippocampus |
|---|---|
| Authors | |
| Issue Date | 2011 |
| Citation | The 9th Biennial Conference of the Chinese Neuroscience Society (CNS 2011) and The 5th Member Congress, Zhengzhou, China, 29 July-1 August 2011. How to Cite? |
| Abstract | Perineuronal heparan sulfate (HS) moieties are implicated in the modulation of neurotransmission by controlling the functional properties of AMPA-type glutamate receptors. We hypothesize that neuronal mechanisms modulate peri-synaptic HS level, thereby regulating synaptic strength and plasticity. To address this, basal synaptic strength and long-term changes in synaptic efficacy in the Schaffer collateral pathway of the rat hippocampus were assessed in relation to strategies that perturb peri-synaptic HS. In hippocampal slices, heparitinase treatment led to dose-dependent attenuation of long-term potentiation (LTP) in correlation with loss of perineuronal HS … |
| Description | Abstract no. P-110 |
| Persistent Identifier | http://hdl.handle.net/10722/136413 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ma, CW | en_US |
| dc.contributor.author | Cham, WC | en_US |
| dc.contributor.author | Lai, CH | en_US |
| dc.contributor.author | Shum, DKY | en_US |
| dc.contributor.author | Chan, YS | en_US |
| dc.date.accessioned | 2011-07-27T02:15:36Z | - |
| dc.date.available | 2011-07-27T02:15:36Z | - |
| dc.date.issued | 2011 | en_US |
| dc.identifier.citation | The 9th Biennial Conference of the Chinese Neuroscience Society (CNS 2011) and The 5th Member Congress, Zhengzhou, China, 29 July-1 August 2011. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/136413 | - |
| dc.description | Abstract no. P-110 | - |
| dc.description.abstract | Perineuronal heparan sulfate (HS) moieties are implicated in the modulation of neurotransmission by controlling the functional properties of AMPA-type glutamate receptors. We hypothesize that neuronal mechanisms modulate peri-synaptic HS level, thereby regulating synaptic strength and plasticity. To address this, basal synaptic strength and long-term changes in synaptic efficacy in the Schaffer collateral pathway of the rat hippocampus were assessed in relation to strategies that perturb peri-synaptic HS. In hippocampal slices, heparitinase treatment led to dose-dependent attenuation of long-term potentiation (LTP) in correlation with loss of perineuronal HS … | - |
| dc.language | eng | en_US |
| dc.relation.ispartof | CNS 2011 Biennial Conference & the 5th Member Congress | en_US |
| dc.relation.ispartof | 中国神经科学学会第九届全国学术会议暨第五次会员代表大会 | - |
| dc.title | The role of proheparanase in synaptic plasticity at the hippocampus | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Ma, CW: cwma2010@hku.hk | en_US |
| dc.identifier.email | Cham, WC: chamwc@hku.hk | en_US |
| dc.identifier.email | Lai, CH: chlaib@hku.hk | en_US |
| dc.identifier.email | Shum, DKY: shumdkhk@hkucc.hku.hk | en_US |
| dc.identifier.email | Chan, YS: yschan@hku.hk | en_US |
| dc.identifier.authority | Lai, CH=rp00396 | en_US |
| dc.identifier.authority | Shum, DKY=rp00321 | en_US |
| dc.description.nature | postprint | - |
| dc.identifier.hkuros | 187664 | en_US |