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- Publisher Website: 10.1002/pd.2455
- Scopus: eid_2-s2.0-77950671923
- PMID: 20155783
- WOS: WOS:000277629600004
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Article: Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting down syndrome pregnancies
Title | Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting down syndrome pregnancies | ||||
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Authors | |||||
Keywords | Anti-Mullerian hormone Down syndrome Pregnancy | ||||
Issue Date | 2010 | ||||
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 | ||||
Citation | Prenatal Diagnosis, 2010, v. 30 n. 4, p. 320-324 How to Cite? | ||||
Abstract | Objective: To compare the difference in maternal serum anti-Mullerian hormone (AMH) level between Down syndrome pregnancies and unaffected pregnancies, and to evaluate its performance as a screening marker for Down syndrome pregnancy. Method: A total of 145 pregnancies affected by foetal Down syndrome and 290 unaffected controls matched with maternal age and gestational age were selected, and their archived first or second trimester serum retrieved for AMH assay. Results: There was no significant difference in maternal serum AMH level between pregnancies affected and unaffected by foetal Down syndrome. Our first trimester serum samples had higher AMH concentration compared to second trimester samples. Conclusions: Maternal serum AMH level, as a marker of ovarian age, is not superior to chronological age in predicting Down syndrome pregnancies. Despite the cross-sectional nature of our study, the variation of maternal serum AMH concentration with gestational age warrants further investigation. Copyright © 2010 John Wiley & Sons, Ltd. | ||||
Persistent Identifier | http://hdl.handle.net/10722/135633 | ||||
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.986 | ||||
ISI Accession Number ID |
Funding Information: This study was supported by a small project funding grant from the Committee on Research and Conference Grants, University of Hong Kong. The authors would like to thank Ms Benancy Wong for performing the AMH assay and Mr Victor Ng for his technical support. | ||||
References |
DC Field | Value | Language |
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dc.contributor.author | Li, HWR | en_HK |
dc.contributor.author | Hui, PW | en_HK |
dc.contributor.author | Tang, MHY | en_HK |
dc.contributor.author | Lau, ETK | en_HK |
dc.contributor.author | Yeung, WSB | en_HK |
dc.contributor.author | Ho, PC | en_HK |
dc.contributor.author | Ng, EHY | en_HK |
dc.date.accessioned | 2011-07-27T01:38:07Z | - |
dc.date.available | 2011-07-27T01:38:07Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Prenatal Diagnosis, 2010, v. 30 n. 4, p. 320-324 | en_HK |
dc.identifier.issn | 0197-3851 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/135633 | - |
dc.description.abstract | Objective: To compare the difference in maternal serum anti-Mullerian hormone (AMH) level between Down syndrome pregnancies and unaffected pregnancies, and to evaluate its performance as a screening marker for Down syndrome pregnancy. Method: A total of 145 pregnancies affected by foetal Down syndrome and 290 unaffected controls matched with maternal age and gestational age were selected, and their archived first or second trimester serum retrieved for AMH assay. Results: There was no significant difference in maternal serum AMH level between pregnancies affected and unaffected by foetal Down syndrome. Our first trimester serum samples had higher AMH concentration compared to second trimester samples. Conclusions: Maternal serum AMH level, as a marker of ovarian age, is not superior to chronological age in predicting Down syndrome pregnancies. Despite the cross-sectional nature of our study, the variation of maternal serum AMH concentration with gestational age warrants further investigation. Copyright © 2010 John Wiley & Sons, Ltd. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 | en_HK |
dc.relation.ispartof | Prenatal Diagnosis | en_HK |
dc.rights | Prenatal Diagnosis. Copyright © John Wiley & Sons Ltd. | - |
dc.subject | Anti-Mullerian hormone | en_HK |
dc.subject | Down syndrome | en_HK |
dc.subject | Pregnancy | en_HK |
dc.subject.mesh | Anti-Mullerian Hormone - blood | - |
dc.subject.mesh | Down Syndrome - blood | - |
dc.subject.mesh | Gestational Age | - |
dc.subject.mesh | Maternal Age | - |
dc.subject.mesh | Pregnancy - blood | - |
dc.title | Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting down syndrome pregnancies | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Li, HWR: raymondli@hku.hk | en_HK |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | en_HK |
dc.identifier.email | Yeung, WSB: wsbyeung@hkucc.hku.hk | en_HK |
dc.identifier.email | Ho, PC: pcho@hku.hk | en_HK |
dc.identifier.email | Ng, EHY: nghye@hku.hk | en_HK |
dc.identifier.authority | Li, HWR=rp01649 | en_HK |
dc.identifier.authority | Tang, MHY=rp01701 | en_HK |
dc.identifier.authority | Yeung, WSB=rp00331 | en_HK |
dc.identifier.authority | Ho, PC=rp00325 | en_HK |
dc.identifier.authority | Ng, EHY=rp00426 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/pd.2455 | en_HK |
dc.identifier.pmid | 20155783 | - |
dc.identifier.scopus | eid_2-s2.0-77950671923 | en_HK |
dc.identifier.hkuros | 187015 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77950671923&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 30 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 320 | en_HK |
dc.identifier.epage | 324 | en_HK |
dc.identifier.isi | WOS:000277629600004 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Li, HWR=7404724295 | en_HK |
dc.identifier.scopusauthorid | Hui, PW=7101621830 | en_HK |
dc.identifier.scopusauthorid | Tang, MHY=8943401300 | en_HK |
dc.identifier.scopusauthorid | Lau, ETK=7103086081 | en_HK |
dc.identifier.scopusauthorid | Yeung, WSB=7102370745 | en_HK |
dc.identifier.scopusauthorid | Ho, PC=7402211440 | en_HK |
dc.identifier.scopusauthorid | Ng, EHY=35238184300 | en_HK |
dc.identifier.issnl | 0197-3851 | - |