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- Publisher Website: 10.1002/lt.22362
- Scopus: eid_2-s2.0-80053291972
- PMID: 21688383
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Article: Can positron emission tomography with the dual tracers [ 11C]acetate and [ 18F]fludeoxyglucose predict microvascular invasion in hepatocellular carcinoma?
Title | Can positron emission tomography with the dual tracers [ 11C]acetate and [ 18F]fludeoxyglucose predict microvascular invasion in hepatocellular carcinoma? |
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Authors | |
Keywords | Acetic acid c 11 Fluorodeoxyglucose f 18 Advanced cancer Cancer invasion Cancer recurrence |
Issue Date | 2011 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021 |
Citation | Liver Transplantation, 2011, v. 17 n. 10, p. 1218-1225 How to Cite? |
Abstract | Microvascular invasion is a poor prognostic indicator of the recurrence of hepatocellular carcinoma (HCC) after surgical treatment. Positron emission tomography (PET) with [ 18F]fludeoxyglucose ([ 18F]FDG) as a tracer has been employed to predict the prognosis before surgery for various kinds of tumors, but it has not been found to be sensitive enough for HCC. Thus, [ 11C]acetate has been adopted as an additional tracer. This study was designed to evaluate the ability of dual-tracer PET ([ 18F]FDG and [ 11C]acetate) to predict microvascular invasion before liver resection or transplantation. Fifty-eight HCC patients who were preoperatively examined with whole-body dual-tracer PET were studied. Twenty-five patients were [ 18F]FDG-positive, and 56 were [ 11C]acetate-positive. The sensitivity of [ 18F]FDG in detecting primary HCC was 43%, and the sensitivity of [ 11C]acetate was 93%. Twenty-nine patients had HCC with microvascular invasion according to the final pathological examination. The sensitivity, specificity, positive predictive value, and negative predictive value of [ 18F]FDG PET in predicting microvascular invasion were 55.2%, 69%, 64%, and 60.6%, respectively; the corresponding rates for [ 11C]acetate PET were 93.1%, 0%, 48.2%, and 0%. The factors associated with HCC recurrence, which included multifocal involvement, a large tumor size, microsatellite lesions, poor HCC differentiation, and an advanced stage of disease, were analyzed and compared with positive PET results. A tumor size greater than 5 cm was significantly associated with positive [ 18F]FDG PET results; [ 11C]acetate was not associated with poor prognostic indicators. Preoperative [ 18F]FDG PET may predict microvascular invasion. The addition of [ 11C]acetate improves the overall sensitivity of PET, but it has no incremental value in predicting microvascular invasion. © 2011 AASLD. |
Persistent Identifier | http://hdl.handle.net/10722/135520 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 1.700 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Cheung, TT | en_HK |
dc.contributor.author | Chan, SC | en_HK |
dc.contributor.author | Ho, CL | en_HK |
dc.contributor.author | Chok, KSH | en_HK |
dc.contributor.author | Chan, ACY | en_HK |
dc.contributor.author | Sharr, WW | en_HK |
dc.contributor.author | Ng, KKC | en_HK |
dc.contributor.author | Poon, RTP | en_HK |
dc.contributor.author | Lo, CM | en_HK |
dc.contributor.author | Fan, ST | en_HK |
dc.date.accessioned | 2011-07-27T01:36:26Z | - |
dc.date.available | 2011-07-27T01:36:26Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Liver Transplantation, 2011, v. 17 n. 10, p. 1218-1225 | en_HK |
dc.identifier.issn | 1527-6465 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/135520 | - |
dc.description.abstract | Microvascular invasion is a poor prognostic indicator of the recurrence of hepatocellular carcinoma (HCC) after surgical treatment. Positron emission tomography (PET) with [ 18F]fludeoxyglucose ([ 18F]FDG) as a tracer has been employed to predict the prognosis before surgery for various kinds of tumors, but it has not been found to be sensitive enough for HCC. Thus, [ 11C]acetate has been adopted as an additional tracer. This study was designed to evaluate the ability of dual-tracer PET ([ 18F]FDG and [ 11C]acetate) to predict microvascular invasion before liver resection or transplantation. Fifty-eight HCC patients who were preoperatively examined with whole-body dual-tracer PET were studied. Twenty-five patients were [ 18F]FDG-positive, and 56 were [ 11C]acetate-positive. The sensitivity of [ 18F]FDG in detecting primary HCC was 43%, and the sensitivity of [ 11C]acetate was 93%. Twenty-nine patients had HCC with microvascular invasion according to the final pathological examination. The sensitivity, specificity, positive predictive value, and negative predictive value of [ 18F]FDG PET in predicting microvascular invasion were 55.2%, 69%, 64%, and 60.6%, respectively; the corresponding rates for [ 11C]acetate PET were 93.1%, 0%, 48.2%, and 0%. The factors associated with HCC recurrence, which included multifocal involvement, a large tumor size, microsatellite lesions, poor HCC differentiation, and an advanced stage of disease, were analyzed and compared with positive PET results. A tumor size greater than 5 cm was significantly associated with positive [ 18F]FDG PET results; [ 11C]acetate was not associated with poor prognostic indicators. Preoperative [ 18F]FDG PET may predict microvascular invasion. The addition of [ 11C]acetate improves the overall sensitivity of PET, but it has no incremental value in predicting microvascular invasion. © 2011 AASLD. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021 | en_HK |
dc.relation.ispartof | Liver Transplantation | en_HK |
dc.rights | Liver Transplantation. Copyright © John Wiley & Sons, Inc. | - |
dc.subject | Acetic acid c 11 | - |
dc.subject | Fluorodeoxyglucose f 18 | - |
dc.subject | Advanced cancer | - |
dc.subject | Cancer invasion | - |
dc.subject | Cancer recurrence | - |
dc.title | Can positron emission tomography with the dual tracers [ 11C]acetate and [ 18F]fludeoxyglucose predict microvascular invasion in hepatocellular carcinoma? | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1527-6465&volume=17&issue=10&spage=1218&epage=1225&date=2011&atitle=Can+positron+emission+tomography+with+the+dual+tracers+[11C]acetate+and+[18F]fludeoxyglucose+predict+microvascular+invasion+in+hepatocellular+carcinoma? | - |
dc.identifier.email | Chan, SC: chanlsc@hkucc.hku.hk | en_HK |
dc.identifier.email | Chan, ACY: acchan@hku.hk | en_HK |
dc.identifier.email | Poon, RTP: poontp@hkucc.hku.hk | en_HK |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | en_HK |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_HK |
dc.identifier.authority | Chan, SC=rp01568 | en_HK |
dc.identifier.authority | Chan, ACY=rp00310 | en_HK |
dc.identifier.authority | Poon, RTP=rp00446 | en_HK |
dc.identifier.authority | Lo, CM=rp00412 | en_HK |
dc.identifier.authority | Fan, ST=rp00355 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1002/lt.22362 | en_HK |
dc.identifier.pmid | 21688383 | - |
dc.identifier.scopus | eid_2-s2.0-80053291972 | en_HK |
dc.identifier.hkuros | 187485 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80053291972&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 17 | en_HK |
dc.identifier.issue | 10 | en_HK |
dc.identifier.spage | 1218 | en_HK |
dc.identifier.epage | 1225 | en_HK |
dc.identifier.isi | WOS:000295234700013 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Cheung, TT=7103334165 | en_HK |
dc.identifier.scopusauthorid | Chan, SC=7404255575 | en_HK |
dc.identifier.scopusauthorid | Ho, CL=7404653628 | en_HK |
dc.identifier.scopusauthorid | Chok, KSH=6508229426 | en_HK |
dc.identifier.scopusauthorid | Chan, ACY=15828849100 | en_HK |
dc.identifier.scopusauthorid | Sharr, WW=36864499000 | en_HK |
dc.identifier.scopusauthorid | Ng, KKC=7403179075 | en_HK |
dc.identifier.scopusauthorid | Poon, RTP=7103097223 | en_HK |
dc.identifier.scopusauthorid | Lo, CM=7401771672 | en_HK |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_HK |
dc.identifier.issnl | 1527-6465 | - |