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Conference Paper: Intra-orbital distance as a record of social brain dysmorphology in autism

TitleIntra-orbital distance as a record of social brain dysmorphology in autism
Authors
Cheung, CYu, GKKYam, AMyint, VYee, YFChua, SEMcAlonan, GM
Issue Date2011
PublisherThe International Society for Magnetic Resonance in Medicine.
Citation
The 19th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2011), Montreal, Canada, 7-13 May 2011. In Conference Proceedings, 2011, p. 2522 How to Cite?
AbstractMinor Physical Anomalies (MPAs) arise during the first trimester of prenatal life and occur more frequently in autism and related neurodevelopmental disorders. We measured intra-orbital distances from T1 weighted images of children with autism aged 6 – 16 years and typically developing peers. We report a significant increase in intra-orbital distance in autism. Using voxel-wise linear regression analysis intra-orbital distances were found to positively correlate with the volume of inferio-temporal regions including the amygdala in the autism group only. We suggest that intra-orbital MPA may provide a ‘fossil’ record of much earlier childhood brain expansion in autism.
Persistent Identifierhttp://hdl.handle.net/10722/135418

 

DC FieldValueLanguage
dc.contributor.authorCheung, Cen_US
dc.contributor.authorYu, GKKen_US
dc.contributor.authorYam, Aen_US
dc.contributor.authorMyint, Ven_US
dc.contributor.authorYee, YFen_US
dc.contributor.authorChua, SEen_US
dc.contributor.authorMcAlonan, GM-
dc.date.accessioned2011-07-27T01:34:55Z-
dc.date.available2011-07-27T01:34:55Z-
dc.date.issued2011en_US
dc.identifier.citationThe 19th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2011), Montreal, Canada, 7-13 May 2011. In Conference Proceedings, 2011, p. 2522en_US
dc.identifier.urihttp://hdl.handle.net/10722/135418-
dc.description.abstractMinor Physical Anomalies (MPAs) arise during the first trimester of prenatal life and occur more frequently in autism and related neurodevelopmental disorders. We measured intra-orbital distances from T1 weighted images of children with autism aged 6 – 16 years and typically developing peers. We report a significant increase in intra-orbital distance in autism. Using voxel-wise linear regression analysis intra-orbital distances were found to positively correlate with the volume of inferio-temporal regions including the amygdala in the autism group only. We suggest that intra-orbital MPA may provide a ‘fossil’ record of much earlier childhood brain expansion in autism.-
dc.languageengen_US
dc.publisherThe International Society for Magnetic Resonance in Medicine.-
dc.relation.ispartofISMRM 19th Annual Meeting Proceedingsen_US
dc.titleIntra-orbital distance as a record of social brain dysmorphology in autismen_US
dc.typeConference_Paperen_US
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_US
dc.identifier.emailYu, GKK: gkkyu@hku.hken_US
dc.identifier.emailChua, SE: sechua@hku.hken_US
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_US
dc.identifier.authorityCheung, C=rp01574en_US
dc.identifier.authorityChua, SE=rp00438en_US
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros187369en_US
dc.identifier.spage2522-
dc.identifier.epage2522-
dc.publisher.placeCanada-
dc.description.otherThe 19th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Montreal, Canada, 7-13 May 2011. In Proceedings of the 19th ISMRM, 2011, p. 2522-

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