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- Publisher Website: 10.1002/jbm.b.31236
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- PMID: 18937262
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Article: The use of brushite calcium phosphate cement for enhancement of bone-tendon integration in an anterior cruciate ligament reconstruction rabbit model
Title | The use of brushite calcium phosphate cement for enhancement of bone-tendon integration in an anterior cruciate ligament reconstruction rabbit model | ||||||
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Authors | |||||||
Keywords | Anterior cruciate ligament reconstruction Bone-tendon healing Brushite Calcium phosphate cement Microcomputed tomography | ||||||
Issue Date | 2009 | ||||||
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/ | ||||||
Citation | Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2009, v. 89 n. 2, p. 466-474 How to Cite? | ||||||
Abstract | This study was designed to investigate the osteoconductivity and bioresorption of brushite calcium phosphate cement (CPC) in bone-tendon interface healing after anterior cruciate ligament (ACL) reconstruction. Surgical reconstruction using grafted tendon in bone tunnel was performed bilaterally in 28 skeletal mature rabbits. Brushite CPC was implanted between grafted tendon and bone tunnel of one limb with the contralateral one as the control. A batch of 14 rabbits was sacrificed at 6 and 12 weeks, respectively, after surgery. At each time point, six rabbits were used for micro-CT and subsequent histological examinations, whereas the remaining eight rabbits were used for pull-out testing. The components of brushite CPC-dicalcium phosphate dihydrate matrix degraded rapidly with beta-tricalcium phosphate granules left for guiding new bone formation. Brushite CPC augmented the peri-tendon bone volume and promoted bone growth into the healing interface. The ultimate strength and stiffness of the graft-tunnel complexes on experimental side was higher than that of the control by 117% and 102%, respectively, at 6 weeks postoperatively (p < 0.05 for both). The use of brushite CPC caused a paradigm shift in failure mode from intra-tunnel to intra-articular portion at 12 weeks postoperatively (p = 0.013). Brushite CPC significantly enhanced the bone-tendon integration after ACL reconstruction, which provided a scientific basis for clinical application. © 2008 Wiley Periodicals, Inc. | ||||||
Persistent Identifier | http://hdl.handle.net/10722/135303 | ||||||
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 0.634 | ||||||
ISI Accession Number ID |
Funding Information: Contract grant sponsor: Research Grant Council Earmarked Grants 06-07. Hong Kong SAR, China: Contract grant number: CUHK4497/06M |
DC Field | Value | Language |
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dc.contributor.author | Wen, CY | en_US |
dc.contributor.author | Qin, L | en_US |
dc.contributor.author | Lee, KM | en_US |
dc.contributor.author | Chan, KM | en_US |
dc.date.accessioned | 2011-07-27T01:31:49Z | - |
dc.date.available | 2011-07-27T01:31:49Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2009, v. 89 n. 2, p. 466-474 | en_US |
dc.identifier.issn | 1552-4973 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/135303 | - |
dc.description.abstract | This study was designed to investigate the osteoconductivity and bioresorption of brushite calcium phosphate cement (CPC) in bone-tendon interface healing after anterior cruciate ligament (ACL) reconstruction. Surgical reconstruction using grafted tendon in bone tunnel was performed bilaterally in 28 skeletal mature rabbits. Brushite CPC was implanted between grafted tendon and bone tunnel of one limb with the contralateral one as the control. A batch of 14 rabbits was sacrificed at 6 and 12 weeks, respectively, after surgery. At each time point, six rabbits were used for micro-CT and subsequent histological examinations, whereas the remaining eight rabbits were used for pull-out testing. The components of brushite CPC-dicalcium phosphate dihydrate matrix degraded rapidly with beta-tricalcium phosphate granules left for guiding new bone formation. Brushite CPC augmented the peri-tendon bone volume and promoted bone growth into the healing interface. The ultimate strength and stiffness of the graft-tunnel complexes on experimental side was higher than that of the control by 117% and 102%, respectively, at 6 weeks postoperatively (p < 0.05 for both). The use of brushite CPC caused a paradigm shift in failure mode from intra-tunnel to intra-articular portion at 12 weeks postoperatively (p = 0.013). Brushite CPC significantly enhanced the bone-tendon integration after ACL reconstruction, which provided a scientific basis for clinical application. © 2008 Wiley Periodicals, Inc. | - |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/ | - |
dc.relation.ispartof | Journal of Biomedical Materials Research Part B: Applied Biomaterials | en_US |
dc.rights | Journal of Biomedical Materials Research Part B: Applied Biomaterials. Copyright © John Wiley & Sons, Inc. | - |
dc.subject | Anterior cruciate ligament reconstruction | - |
dc.subject | Bone-tendon healing | - |
dc.subject | Brushite | - |
dc.subject | Calcium phosphate cement | - |
dc.subject | Microcomputed tomography | - |
dc.subject.mesh | Anterior Cruciate Ligament - pathology - surgery | - |
dc.subject.mesh | Bone Cements - chemistry - metabolism | - |
dc.subject.mesh | Calcium Phosphates - chemistry - metabolism | - |
dc.subject.mesh | Reconstructive Surgical Procedures | - |
dc.subject.mesh | Tendons - cytology - metabolism - transplantation | - |
dc.title | The use of brushite calcium phosphate cement for enhancement of bone-tendon integration in an anterior cruciate ligament reconstruction rabbit model | en_US |
dc.type | Article | en_US |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1552-4973&volume=89&issue=2&spage=466&epage=474&date=2009&atitle=The+use+of+brushite+calcium+phosphate+cement+for+enhancement+of+bone-tendon+integration+in+an+anterior+cruciate+ligament+reconstruction+rabbit+model | en_US |
dc.identifier.email | Wen, CY: paulwen@hku.hk | en_US |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/jbm.b.31236 | - |
dc.identifier.pmid | 18937262 | - |
dc.identifier.scopus | eid_2-s2.0-65949122937 | - |
dc.identifier.hkuros | 188832 | en_US |
dc.identifier.volume | 89 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 466 | en_US |
dc.identifier.epage | 474 | en_US |
dc.identifier.isi | WOS:000265445000021 | - |
dc.identifier.issnl | 1552-4973 | - |