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Article: Adiponectin protects rat hippocampal neurons against excitotoxicity

TitleAdiponectin protects rat hippocampal neurons against excitotoxicity
Authors
KeywordsAdiponectin
AMPK
Hippocampus
Kainic acid
Neuroprotection
Issue Date2011
PublisherSpringer Netherlands. The Journal's web site is located at http://www.springerlink.com/content/0161-9152/
Citation
Age, 2011, v. 33 n. 2, p. 155-165 How to Cite?
AbstractAdiponectin exerts multiple regulatory functions in the body and in the hypothalamus primarily through activation of its two receptors, adiponectin receptor1 and adiponectin receptor 2. Recent studies have shown that adiponectin receptors are widely expressed in other areas of the brain including the hippocampus. However, the functions of adiponectin in brain regions other than the hypothalamus are not clear. Here, we report that adiponectin can protect cultured hippocampal neurons against kainic acid-induced (KA) cytotoxicity. Adiponectin reduced the level of reactive oxygen species, attenuated apoptotic cell death, and also suppressed activation of caspase-3 induced by KA. Pretreatment of hippocampal primary neurons with an AMPK inhibitor, compound C, abolished adiponectin-induced neuronal protection. The AMPK activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, attenuated KA-induced caspase-3 activity. These findings suggest that the AMPK pathway is critically involved in adiponectin-induced neuroprotection and may mediate the antioxidative and anti-apoptotic properties of adiponectin. © 2010 US Government.
Persistent Identifierhttp://hdl.handle.net/10722/135000
ISSN
2018 Impact Factor: 4.648
ISI Accession Number ID
Funding AgencyGrant Number
National Institute on Aging, National Institutes of Health, USA
Funding Information:

The authors would like to thank Drs. Min Zhu and Haiyang Jiang for technical assistance, Dr. Peter Rapp for suggestions and thoughtful review of the manuscript and Kris Rozankowski for editing the manuscript. This work was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health, USA

References

 

DC FieldValueLanguage
dc.contributor.authorQiu, Gen_HK
dc.contributor.authorWan, Ren_HK
dc.contributor.authorHu, Jen_HK
dc.contributor.authorMattson, MPen_HK
dc.contributor.authorSpangler, Een_HK
dc.contributor.authorLiu, Sen_HK
dc.contributor.authorYau, SYen_HK
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorGleichmann, Men_HK
dc.contributor.authorIngram, DKen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorZou, Sen_HK
dc.date.accessioned2011-07-27T01:25:41Z-
dc.date.available2011-07-27T01:25:41Z-
dc.date.issued2011en_HK
dc.identifier.citationAge, 2011, v. 33 n. 2, p. 155-165en_HK
dc.identifier.issn0161-9152en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135000-
dc.description.abstractAdiponectin exerts multiple regulatory functions in the body and in the hypothalamus primarily through activation of its two receptors, adiponectin receptor1 and adiponectin receptor 2. Recent studies have shown that adiponectin receptors are widely expressed in other areas of the brain including the hippocampus. However, the functions of adiponectin in brain regions other than the hypothalamus are not clear. Here, we report that adiponectin can protect cultured hippocampal neurons against kainic acid-induced (KA) cytotoxicity. Adiponectin reduced the level of reactive oxygen species, attenuated apoptotic cell death, and also suppressed activation of caspase-3 induced by KA. Pretreatment of hippocampal primary neurons with an AMPK inhibitor, compound C, abolished adiponectin-induced neuronal protection. The AMPK activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, attenuated KA-induced caspase-3 activity. These findings suggest that the AMPK pathway is critically involved in adiponectin-induced neuroprotection and may mediate the antioxidative and anti-apoptotic properties of adiponectin. © 2010 US Government.en_HK
dc.languageengen_US
dc.publisherSpringer Netherlands. The Journal's web site is located at http://www.springerlink.com/content/0161-9152/en_HK
dc.relation.ispartofAgeen_HK
dc.subjectAdiponectinen_HK
dc.subjectAMPKen_HK
dc.subjectHippocampusen_HK
dc.subjectKainic aciden_HK
dc.subjectNeuroprotectionen_HK
dc.subject.meshAMP-Activated Protein Kinases - antagonists & inhibitors - metabolismen_HK
dc.subject.meshAdiponectin - pharmacology - physiologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshCaspase 3 - metabolismen_HK
dc.subject.meshCell Death - drug effectsen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshEnzyme Activationen_HK
dc.subject.meshHippocampus - drug effects - metabolismen_HK
dc.subject.meshKainic Acid - toxicityen_HK
dc.subject.meshNeurons - drug effectsen_HK
dc.subject.meshNeuroprotective Agents - pharmacologyen_HK
dc.subject.meshPyrazoles - pharmacologyen_HK
dc.subject.meshPyrimidines - pharmacologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReactive Oxygen Species - metabolismen_HK
dc.subject.meshReceptors, Adiponectin - metabolismen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshSignal Transductionen_HK
dc.titleAdiponectin protects rat hippocampal neurons against excitotoxicityen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1007/s11357-010-9173-5en_HK
dc.identifier.pmid20842535-
dc.identifier.scopuseid_2-s2.0-79959544623en_HK
dc.identifier.hkuros186214en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79959544623&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue2en_HK
dc.identifier.spage155en_HK
dc.identifier.epage165en_HK
dc.identifier.isiWOS:000291056200005-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridQiu, G=36790708100en_HK
dc.identifier.scopusauthoridWan, R=7005190694en_HK
dc.identifier.scopusauthoridHu, J=16052804900en_HK
dc.identifier.scopusauthoridMattson, MP=36046169900en_HK
dc.identifier.scopusauthoridSpangler, E=7005165249en_HK
dc.identifier.scopusauthoridLiu, S=35115266100en_HK
dc.identifier.scopusauthoridYau, SY=24330296200en_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.scopusauthoridGleichmann, M=9247794900en_HK
dc.identifier.scopusauthoridIngram, DK=7202128918en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridZou, S=13613605800en_HK
dc.identifier.citeulike7875707-
dc.identifier.issnl0161-9152-

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